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Progress in Chemistry 2007, Vol. 19 Issue (05): 689-694 Previous Articles   Next Articles

• Review •

Functional Gold Clusters and Their Applications in Biomedicine

Yang Xiaochao1; Qian Junzhen1; Wan Qiaoling1 ;Mo Zhihong1,2*   

  1. 1.Colleges of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China;
    2.Micro-System Research Center ,Chongqing University, Chongqing 400044, China
  • Received: Revised: Online: Published:
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Mixed monolayer protected gold clusters (Au-MMPCs) can be prepared by modifying the monolayer protected gold clusters（Au-MPCs） with various bioactive thiol or disulfide ligands. The interaction of these Au-MMPCs with biomaterials, such as protein, nucleic acid, and cell membrane, made them useful in cell transfection, drug delivery and enzyme activity regulation. In this paper, the factors that affect the synthesis of gold clusters in Brust-Schiffrin reaction are introduced. The strategies and mechanisms of preparation of mixed monolayer protected gold clusters (Au-MMPCs) based on the Brust-Schiffrin reaction are summarized, in which the ligand exchange reaction are described in detail. The applications of Au-MMPCs in biomedicine are reviewed.
Key words: gold clusters, ligand exchange, cell transfection, drug delivery, enzyme activity regulation

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