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Progress in Chemistry 2019, Vol. 31 Issue (6): 783-790 DOI: 10.7536/PC181029   Next Articles

Nanoscale Metal Organic Frameworks for Drug Delivery

Xinyi Lai, Zhiyong Wang**(), Yongtai Zheng, Yongming Chen**()   

  1. School of Materials Science and Engineering, Key Laboratory of Polymeric Composite Materials and Functional Materials of Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China
  • Received: Online: Published:
  • Contact: Zhiyong Wang, Yongming Chen
  • About author:
    ** E-mail: (Zhiyong Wang);
    (Yongming Chen)
  • Supported by:
    National Natural Science Foundation of China(51503230); National Natural Science Foundation of China(81471778); National Natural Science Foundation of China(51203177); Guangdong Innovative and Entrepreneurial Research Team Program(2013S086); Science and Technology Program of Guangzhou,China(201804010101)
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Metal-organic frameworks(MOFs), a class of self-assembled porous materials with metal ions and organic ligands, have attracted increasing research attention owing to their high porosity, tunable pore size, large surface area and multiple structures. In recent years, MOFs have been extensively investigated in gas storage, separation, catalysis and other fields. When the size of these hybrid materials drops down to nanosized scale, the regular morphology and unique properties make NMOFs become promising candidates for drug delivery. Compared to other nanocarriers, NMOFs provide multiple binding sites for a variety of small-molecule drugs and biomacromolecule via inclusion or surface conjugation. These chemical modifications do not affect NMOFs' intrinsic physicochemical properties. Moreover, the facile synthesis and mild preparation conditions endow NMOFs with advantages in biomedicine. Nowadays, NMOFs have been demonstrated with multifunctionalities and stimuli-responsive controlled release in vivo. Therefore, a detailed review of the application of NMOFs in controlled drug delivery of anticancer drugs, photosensitizer and nucleic acids is provided here.

Key words: metal-organic frameworks(MOFs), nanoparticle, drug delivery, anticancer drug, photosensitizer, nucleic acid
Fig. 1 Schematic showing the general procedure for the NMOF with lipid and PEG coating[20].Copyright 2014, the Royal Society of Chemistry
Fig. 2 The synthesis of PDA-PCM@ZIF-8/DOX and controllable combined thermo-chemotherapy.(a) Controlled DOX release behaviors of the PDA-PCM@ZIF-8/DOX at different pH under NIR irradiation.(b) Controlled DOX release behaviors of the PDA@ZIF-8/DOX and PDA-PCM@ZIF-8/DOX at same pH under 37 ℃ shaking with additional 5 min NIR irradiation or not[23]. Copyright 2018, Elsevier
Fig. 3 Illustration of PCN-224 structure.(a) six-connected Zr6 cluster(Zr6O4(OH)4(H2O)6(OH)6(COO)6), tetratopic linker(tetrakis(4-carboxyphenyl)porphyrin(H2TCPP)), and 3D nanoporous framework of PCN-224.(b) A cubic unit of PCN-224 and schematic illustration of spherical PCN-224 nanoparticles on the basis of construction of cubic units, yielding different sizes.(c) Control experiments of cytotoxicity in HeLa cells upon light irradiation of 420 and 630 nm in the absence and presence of 90 nm-PCN-224. Irradiation time=30 min.(d) Comparison of in vitro PDT efficacy of pristine 1/4FA-PCN-224and PCN-224 in HeLa cells[30]. Copyright 2016, American Chemical Society
Fig. 4 (A) Schematic illustration for preparation of O2@UiO-66@ICG@RBC.(B) Schematic illustration of NIR-triggered O2 releasing and enhanced PDT mechanism[32]. Copyright 2018, Elsevier
Fig. 5 Mechanism of the reversal of drug resistance and induced apoptosis by the disruption of microtubule in MCF-7/T(Taxol-Resistance) Cancer Cells[39]. Copyright 2017, American Chemical Society
Fig. 6 Synthesis and DNA Functionalization of UiO-66-N3 Nanoparticles.(A) Synthesis of UiO-66-N3(Zr6O4OH4(C8H3O4-N3)6) nano-particles.(B) DNA functionalization of UiO-66-N3 nanoparticles, utilizing DNA functionalized with DBCO.(C) Strain promoted click reaction between a MOF strut and DNA. Zirconium atoms=blue; oxygen atoms=red; carbon atoms=black; azide groups=green. Hydrogen atoms are omitted for clarity[43]. Copyright 2014, American Chemical Society
Fig. 7 Fine-tuning of interactions between ssDNA and MOFs.(a) Illustration of ssDNA inclusion in MOFs composed of bio-compatible organic linkers and with precisely controlled pore sizes.(b) Gradual increase of interaction between ssDNA and MOFs as the pore size of MOF extended progressively. Relatively mild interactions guarantee the uptake and protection of ssDNA in the MOF pores, and also provide reversibility for their release[44]. Copyright 2018, Nature Publishing Group
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