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化学进展 2011, Vol. 23 Issue (8): 1611-1617 前一篇   后一篇

• 综述与评论 •

超临界流体输运技术在缓/控释药物制备中的应用

倪敏, 徐琴琴, 徐刚, 王恩俊, 银建中*   

  1. 大连理工大学化工机械学院 大连 116024
  • 收稿日期:2010-11-01 修回日期:2011-01-01 出版日期:2011-08-24 发布日期:2011-07-25
  • 通讯作者: 银建中 E-mail:jzyin@dlut.edu.cn
  • 基金资助:

    国家自然科学基金项目(No. 20976028)资助

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Applications of Supercritical Fluid Transport Technology in Preparation of Controlled-Release Drug Delivery Systems

Ni Min, Xu Qinqin, Xu Gang, Wang Enjun, Yin Jianzhong*   

  1. School of Chemical Machinery, Dalian University of Technology, Dalian 116024, China
  • Received:2010-11-01 Revised:2011-01-01 Online:2011-08-24 Published:2011-07-25

缓/控释药物制剂作为一种新药剂是药学研究的热点。本文对近年来超临界流体技术在缓/控释药物系统制备中的研究成果进行了回顾和总结,重点对以超临界流体为溶剂、无机介孔材料为载体制备缓/控释药物系统的方法进行了阐述和评价,内容包括:技术原理、工艺流程、主要影响因素、药效试验、与传统方法比较等。分析了各种工艺流程的优缺点,并指出超临界流体输运技术在缓/控释药物系统制备中所具有的优势。在此基础上,提出药物溶于超临界二氧化碳后所形成的超临界二氧化碳溶液在多孔材料纳米级孔道内的渗透、扩散以及表面物理化学吸附机理、在特定环境氛围下的控制释放机制、药物超临界溶液热力学模型以及制备过程动力学研究等是应该重点关注的理论问题。

关键词： 超临界流体, 输运技术, 浸渍与沉积, 缓/控释药物, 释放

Among the research of new pharmaceutic dosage forms, controlled-release drug delivery system is a very important issue nowdays. In this field, processes using supercritical fluid technology are mostly "clean" process leading to "clean" products. Meanwhile, inorganic porous materials are emerging as a new category of host/guest systems due to some interesting features such as their biological stability and their drug-releasing properties. This review summarizes the applications of supercritical fluid transport technology in preparation of controlled-release drug delivery system in recent years and pays more attention on the method using supercritical fluid as the solvent and inorganic mesoporous materials as the support to prepare this controlled-release drug delivery system. The technical principle, development of technological process and the main influence factors are discussed here besides the drug release experiments and the comparison with the traditional methods. It shows clearly the advantages and disadvantages of various processes, and sums up the superiority of the supercritical transport technology in preparing controlled-release drug delivery system. Although this technique has lots of advantages, as for the papers delivered at present, the research on supercritical fluid transport technology is just at its initial stage of development because there are so many factors influencing the experimental results and these factors are sometimes link-coupled. It is still challenging to make the preparation controllable. It indicates that the diffusion and penetration of the supercritical carbon dioxide drug solution in porous materials, the surface chemical and physical adsorption mechanism should be focused on as well as the controlled drug release mechanism, thermodynamic model and process dynamic.

Contents
1 Introduction
2 Experimental principle, process and equipments
3 Application of inorganic mesoporous materials in preparing controlled-release drug
3.1 Inorganic mesoporous materials
3.2 The traditional impregnation methods
3.3 The experiments using scCO2 and liquid CO2
3.4 Analysis of influence factors
4 Conclusions and outlook

Key words: supercritical fluid, transport technology, impregnation and deposition, controlled-release drug, release

中图分类号: 

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