• 综述与评论 •
张磊, 刘晓燕, 沈晶晶, 卢晓梅, 范曲立, 黄维. 纳米颗粒在抗癌药物可控靶向释放中的应用[J]. 化学进展, doi: 10.7536/PC121205.
Zhang Lei, Liu Xiaoyan, Shen Jingjing, Lu Xiaomei, Fan Quli, Huang Wei. Application of Nanoparticles with Targeting, Triggered Release in Anti-Cancer Drug Delivery[J]. Progress in Chemistry, doi: 10.7536/PC121205.
近些年来癌症发病率不断攀升,引起了人们的普遍关注。由于传统诊疗方法存在弊端,因此开发新型的针对肿瘤组织的多功能的纳米颗粒(如金纳米颗粒、脂质体、聚合物、DNA等)药物输送系统越来越重要。基于生物体的EPR效应或经过表面修饰功能化后,纳米颗粒输送系统可被动或主动靶向到达肿瘤组织,并通过控制温度、pH、超声、光以及酶等激发条件在肿瘤区域实现可控释放。本文简单介绍了肿瘤治疗中常用的具有靶向性、可控释放的纳米颗粒载药系统,系统地描述了纳米颗粒在药物输送系统的最新研究进展,并对今后的发展方向作了展望。
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