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化学进展 2016, Vol. 28 Issue (9): 1289-1298 DOI: 10.7536/PC160418 前一篇   后一篇

• 特约稿 •

仿衣壳结构的巨大中空超分子纳米容器的多组分自组装构筑及其功能

张广录1,2, 张婷1, 周黎鹏1, 孙庆福1*   

  1. 1. 中国科学院福建物质结构研究所 福州 350002;
    2. 中国科学院大学 北京 100049
  • 收稿日期:2016-04-01 修回日期:2016-06-01 出版日期:2016-09-15 发布日期:2016-08-16
  • 通讯作者: 孙庆福 E-mail:qfsun@fjirsm.ac.cn
  • 基金资助:
    国家自然科学基金项目（No.21402201）资助
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Capsid-Inspired Multi-Component Self-Assembly of Nanocontainers: Structure, Functionalization, and Applications

Zhang Guanglu1,2, Zhang Ting1, Zhou Lipeng1, Sun Qingfu1*   

  1. 1. Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002;
    2. University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2016-04-01 Revised:2016-06-01 Online:2016-09-15 Published:2016-08-16
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 21402201).
在自然界病毒衣壳及笼状蛋白质大分子结构的启发下，运用V型双齿桥连吡啶配体和具有平面四方构型的Pd2+离子的溶液配位自组装，一系列具有MnL2n经验分子式的多组分巨大中空“纳米容器”型超分子结构被成功构筑。通过在配体内外引入官能团的策略，可以简单地实现衣壳骨架结构的内外功能化。内功能化后的“纳米容器”具有特殊的高密度相，不仅可以实现对不同类型客体分子的包裹，而且可以作为“纳米反应器”实现尺寸均一可控纳米粒子的原位合成以及小分子的催化转化。外功能化的核壳结构则可以对寡肽、DNA等生物分子具有特定的识别作用。本文对此类“纳米容器”型超分子的设计原理、自组装合成与表征、以及功能化应用等方面进行了综述。
关键词： 自组装, 纳米容器, 功能化, 应用
Inspired by the spontaneous self-assembly of hollow virus capsids and protein cages found in nature, a family of hollow spherical structure with general formula MnL2n can be obtained via the coordination-directed multi-component self-assembly of bent bis(pyridine) ligands and square-planar Pd2+ ions. Endo and exo-hedral functionalization of the nanocontainer complexes have been realized by introduction of functional groups into the organic ligands. Due to the nanoconcentrator effect, endo-functionalised spherical complex could be used not only for the template-synthesis of mono-dispersed polymers or nanoparticles, but also for the catalytic transformations of small substrates. Meanwhile, exo-functionalized complexes can selectively recognize a variety of substrates, such as oligonucleotides and DNA. The design principles, synthesis, characterization and functional applications of such nano-container molecules are summarized in this paper.

Contents
1 Introduction
2 Design and synthesis of the nano-containers
3 Functionalization and applications
3.1 Functional cavity
3.2 Functional surface
4 Conclusion and outlook

Key words: self-assembly, nano-containers, functionalization, application

中图分类号: 

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