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化学进展 2015, Vol. 27 Issue (5): 601-613 DOI: 10.7536/PC141042 前一篇   后一篇

• 综述与评论 •

超顺磁性Fe3O4纳米粒子在磁共振造影中的应用

刘天辉, 常刚, 曹瑞军, 孟令杰*   

  1. 西安交通大学理学院化学系 西安 710049
  • 收稿日期:2014-10-01 修回日期:2015-01-01 出版日期:2015-05-15 发布日期:2015-03-16
  • 通讯作者: 孟令杰 E-mail:menglingjie@mail.xjtu.edu.cn
  • 基金资助:
    国家自然科学基金项目(No.21174087, 21474079),教育部新世纪优秀人才计划(No.NCET-13-0453),中国博士后基金项目(No.2013M540738, 2014T70909)和中央高校基本科研业务费 (No.08142027, 08143101)资助
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Applications of Superparamagnetic Fe3O4 Nanoparticles in Magnetic Resonance Imaging

Liu Tianhui, Chang Gang, Cao Ruijun, Meng Lingjie*   

  1. Department of Chemistry, School of Science, Xi'an Jiaotong University, Xi'an 710049, China
  • Received:2014-10-01 Revised:2015-01-01 Online:2015-05-15 Published:2015-03-16
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No.21174087, 21474079), the Program for New Century Excellent Talents in University (No.NCET-13-0453),the Postdoctoral Fund of China (No.2013M540738, 2014T70909), and the Fundamental Funds for the Central Universities (No.08142027, 08143101).
超顺磁性Fe3O4纳米粒子由于其廉价、低毒及超顺磁等特性,已成为重要的一类磁共振造影剂.本文综述了超顺磁性Fe3O4纳米粒子的可控制备方法,归纳总结影响粒径、结晶度和磁性能的主要因素和影响规律;为进一步提高磁性能并实现多功能,总结了Fe3O4纳米粒子进一步组装和表面改性的方法和机理;系统讨论了Fe3O4纳米粒子的形貌、尺寸和表面性能等对磁性能和生物相容性的影响规律;并指出了Fe3O4纳米粒子在磁共振造影领域潜在的发展方向和研究热点.
关键词： Fe3O4, 纳米材料, 超顺磁, 表面改性, 磁共振成像
Fe3O4 nanomaterials have attracted tremendous attention in the field of magnetic resonance imaging (MRI) because of their low cost, good biocompatibility, favorable superparamagnetic properties. This article focuses on the controlled preparation methods of superparamagnetic Fe3O4 nanoparticles, and provides an in-depth discussion of the key factors and their influence rules for particle size, crystallinity and magnetic properties. The current status of available methodologies and mechanisms for the assembly and surface modification of Fe3O4 nanoparticles are highlighted to generate high performance and multifunction. We also systematically summarize the effect of particle size, morphology and surface properties on the magnetic and toxic properties of Fe3O4 nanoparticles. Finally, the future opportunities and challenges of Fe3O4 nanomaterials used as MRI contrast agents are addressed to our understanding.

Contents
1 Introduction
2 Controllable preparation of Fe3O4 nanoparticles
2.1 Thermal decomposition
2.2 Coprecipitation
2.3 Solvothermal
2.4 Sol-gel
2.5 Microemulsion
2.6 Sonochemical
3 Assembly of Fe3O4 nanoparticles
3.1 Zero-dimensional sphere
3.2 One-dimensional nanochain
3.3 Multidimensional assembly
4 Surface functionalization of Fe3O4 nanoparticles
4.1 Modified by SiO2
4.2 Modified by polymer
4.3 Multifunctional modification
5 Toxicity
6 MRI applications
6.1 Cell imaging
6.2 Tissue/organ imaging
7 Conclusion

Key words: Fe3O4, nanomaterials, superparamagnetic, surface modification, magnetic resonance imaging (MRI)

中图分类号: 

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