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化学进展 2015, Vol. 27 Issue (5): 594-600 DOI: 10.7536/PC141133 前一篇   后一篇

• 综述与评论 •

蛋白质巯基亚硝基化分子机制及其疾病相关性

石婷1, 陈铭1, 陈雄平1, 汪汲涛1, 万锕俊2, 赵一雷*1   

  1. 1. 上海交通大学生命科学技术学院 上海 200240;
    2. 上海交通大学化学化工学院 上海 200240
  • 收稿日期:2014-11-01 修回日期:2015-01-01 出版日期:2015-05-15 发布日期:2015-03-16
  • 通讯作者: 赵一雷 E-mail:yileizhao@sjtu.edu.cn
  • 基金资助:
    国家重点基础研究发展计划(973)项目(No. 2012CB721005, 2013CB966802),国家自然科学基金项目(No. 21102090, J1210047)和上海市教委项目(No. 13YZ032)资助
下载PDF ( 5933 ) 引用
导出 被引次数 ( 3 | 2 )

Molecular Mechanism of Protein S-Nitrosylation and Its Correlation with Human Diseases

Shi Ting1, Chen Ming1, Chen Xiongping1, Wang Jitao1, Wan Ajun2, Zhao Yi-Lei*1   

  1. 1. School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China;
    2. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
  • Received:2014-11-01 Revised:2015-01-01 Online:2015-05-15 Published:2015-03-16
  • Supported by:
    The work was supported by the National Basic Research Program of China (No. 2012CB721005, 2013CB966802), the National Natural Science Foundation of China (No. 21102090, J1210047), and the Shanghai Municipal Council of Science and Technology (No. 13YZ032).
蛋白质翻译后修饰对蛋白质生物学功能起着至关重要的作用.蛋白质巯基亚硝基化(S-nitrosylation,SNO)是一种一氧化氮相关的氧化还原型可逆修饰.它广泛存在于动物、植物和微生物中.近年来的研究表明SNO与蛋白质修饰位点的精细化学结构紧密关联,其中可能存在多种尚未证实的中间体.另一方面,研究发现SNO与肿瘤、炎症、衰老、阿尔茨海默症和帕金森综合症等许多重大疾病相关.为了进一步药物发现与疾病治疗研究的需要,本文对SNO的形成机理与研究现状进行了系统总结,并着重介绍了SNO与相关疾病的研究进展.
关键词： 一氧化氮, 蛋白质巯基亚硝基化, 翻译后修饰, 氧化还原
Protein S-nitrosylation (SNO) is a dynamic and reversible oxidative post-translational modification, widespread in mammals, plants and microorganisms. Previous mechanistic investigation with high-level quantum calculations indicated that many meta-stable intermediates present in the reaction pathway. On the other hand, S-nitrosylation level significantly changes in various human diseases, including tumor, inflammation, aging, Alzheimers disease (AD) and Parkinsons disease (PD). More intensive study has become an urgent need for drug and therapy development. In this paper, molecular mechanism and site-specificity of SNO are summarized, the biological functions are discussed, and especially the correlation between SNO and human diseases are presented.

Contents
1 Formation mechanism of S-nitrosylation (SNO)
2 Site specificity of SNO
3 Detection methods of SNO
4 Biological functions of SNO
5 SNO and diseases
5.1 SNO and transportation of blood
5.2 SNO and diabetes
5.3 SNO and neurodegenerative diseases
5.4 SNO and asthma symptoms
5.5 SNO and cancers
6 SNO and cell apoptosis
7 Conclusion

Key words: nitric oxide, S-nitrosylation, post-translational modification, redox

中图分类号: 

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