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Progress in Chemistry 2008, Vol. 20 Issue (04): 518-525 Previous Articles   Next Articles

• Review •

Asymmetric Synthesis of Chroman Derivatives with Bioactivity

Wang Guixia1 Wang Naixing1** Tang Shi1 Yu Jinlan2 Tang Xinliang2   

  1. (1. Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China; 2. School of Chemical Engineering&Environment, Beijing Institute of Technology, Beijing 100081, China)
  • Received: Revised: Online: Published:
  • Contact: Wang Naixing
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Chroman derivatives are widely distributed in nature. Most chiral chroman derivatives have attracted great interest because of their important biological activities and their applications as intermediates for the synthesis of many important heterocyclic compounds. The key step of the synthesis of chroman derivatives is to construct chiral chroman ring. This review briefly summarizes the recent progress in the methodologies for the synthesis of chiral chroman derivatives. The applications of these methods in stereoselectively constructing chroman ring are discussed in detail.
Key words: chroman derivatives, bioactive molecules, asymmetric synthesis, cyclization

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