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化学进展 2023, Vol. 35 Issue (5): 757-770 DOI: 10.7536/PC220916 前一篇   后一篇

• 综述 •

可卡因免疫及适配体生物传感器

陈戈慧1, 马楠1, 于帅兵1, 王娇1, 孔金明1,*(), 张学记2   

  1. 1 南京理工大学环境与生物工程学院 南京 210094
    2 深圳大学医学部生物医学工程学院 深圳 518060
  • 收稿日期:2022-09-19 修回日期:2022-11-13 出版日期:2023-05-24 发布日期:2023-04-30
  • 基金资助:
    国家自然科学基金项目(21974068); 国家自然科学基金项目(21890740); 国家自然科学基金项目(21890742); 国家自然科学基金项目(9195401)
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Immunity and Aptamer Biosensors for Cocaine Detection

Gehui Chen1, Nan Ma1, Shuaibing Yu1, Jiao Wang1, Jinming Kong1(), Xueji Zhang2   

  1. 1 School of Environmental and Biological Engineering, Nanjing University of Science and Technology,Nanjing 210094, China
    2 School of Biomedical Engineering, Shenzhen University Health Science Center,Shenzhen 518060, China
  • Received:2022-09-19 Revised:2022-11-13 Online:2023-05-24 Published:2023-04-30
  • Contact: * e-mail: j.kong@njust.edu.cn
  • Supported by:
    National Natural Science Foundation of China(21974068); National Natural Science Foundation of China(21890740); National Natural Science Foundation of China(21890742); National Natural Science Foundation of China(9195401)

由于长期滥用可卡因会对人体产生心律失常、心肌梗死、中风、高血压、主动脉僵硬等不良影响,可卡因已成为当今最危险和非法滥用的药物之一,传统的可卡因色谱分析方法存在耗时、样本处理繁琐和操作复杂等缺点。因此,改善传统可卡因分析方法对打击犯罪和发展医学具有一定的积极影响。由于生物传感器的准确性和便携性,基于免疫和适配体技术的生物传感器是检测可卡因的一个重要发展方向。在这篇综述中,主要讲述了近年来不同类型的可卡因生物传感器,涵盖了基于电化学、荧光、比色等方法在可卡因检测上的进展,对可卡因的免疫和适配体生物传感器进行了归纳和综述,并总结了可卡因传感器的优缺点和发展方向。

关键词： 可卡因, 免疫, 适配体, 生物传感器

Cocaine has become one of the most dangerous and illicitly abused drugs today due to the adverse effects of long-term cocaine abuse, such as arrhythmia, myocardial infarction, stroke, hypertension and aortic stiffness. Traditional cocaine chromatographic analysis methods have disadvantages such as time-consuming, cumbersome sample processing and complicated operations. Therefore, improving cocaine detection methods has a certain positive impact on crime-fighting and medicine-developing. Due to the accuracy and portability of biosensors, immunological and aptamer technologies for specific capture of targets have become an important direction for cocaine detection. In this review, different types of cocaine biosensors in recent years are mainly described, covering the research progress of cocaine detection based on electrochemical, fluorescence, colorimetric and other methods. The immuno- and aptamer-based biosensors of cocaine are reviewed, the advantages, disadvantages and development directions of cocaine sensors are summarized.

Contents

1 Introduction

2 Immunosensors for cocaine detection

2.1 Labeled immunosensors

2.2 Label-free immunosensors

3 Aptasensors for cocaine detection

3.1 Fluorescent aptasensors

3.2 Colorimetric aptasensors

3.3 Electrochemical aptasensors

3.4 Other aptasensors

4 Conclusion and outlook

Key words: cocaine, immunity, aptamer, biosensor
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表1 不同可卡因免疫传感器及其检出限对比
Table 1 A comparison of different cocaine immunosensors and their limits of detection
Approach of detection Used sample Linear detection range (mol/L) Limit of detection (mol/L) ref
Electrochemical-based ELISA Water/Saliva/Urine — 4.95×10-13 19
Colorimetric Immuno-microarray Oral fluids 3.63×10-9~9.9×10-7 3.63×10-9 21
LFIA Urine 1.65×10-8~1.65×10-6 1.65×10-8 26
LFIA Saliva 1.65×10-8~3.30×10-6 1.62×10-9 27
Electrochemical Urine/Sweat/Saliva/Serum 1.65×10-8~8.25×10-7 1.19×10-8 30
Fluorescence PBS buffer — 2.30×10-11 31
Electrochemical PBS buffer 0.50×10-6~2.50×10-5 — 34
SHG PBS buffer — 7.5×10-11 35
图1 夹心式LFIA测试条的示意图
Fig. 1 Schematic representation of sandwich-type LFIA test strip
图2 SELEX流程的示意图
Fig. 2 Schematic illustration of SELEX procedure
图3 (a)亚甲基蓝标记的MAs可卡因传感器[46];(b)DFAs与可卡因的组装过程[47];(c)基于TFAs的荧光传感器[48]
Fig. 3 (a) Methylene blue-labeled MAs cocaine biosensor[46]; (b) DFAs and cocaine assembly process[47]; (c) Fluorescent biosensor based on TFAs[48]
表2 不同可卡因适配体传感器及其检出限对比
Table 2 A comparison of different cocaine aptasensors and their detection limits
Method Linear range (mol/L) Detection limit (mol/L) ref
Fluorescence — 5×10-6 62
Fluorescence anisotropy — — 63
Fluorescence 0~1×10-5 5×10-8 (in 10% saliva) 64
Fluorescence 5×10-10~8×10-8 8.4×10-11 65
Fluorescence 0~1×10-10 5.4×10-13 66
Cas-12a based fluorescence 4.7×10-7~1.5×10-2 3.4×10-7 67
EWF-based fluorescence 1×10-5~5×10-3 1.05×10-5 68
Fluorescence 1×10-6~5×10-4 2.5×10-7 69
Fluorescence 1×10-7~1×10-4 4.6×10-9 72
Fluorescence 1×10-8~1×10-4 8×10-10 73
Colorimetric — 8.25×10-9 mol (visual)
7.79×10-9 mol (camera)		 75
Colorimetric 2×10-10~2.5×10-8 9.7×10-10 76
Colorimetric — 1.32×10-8 mol (visual)
1.17×10-8 mol (camera)		 77
Colorimetric 0~1×10-6 7.49×10-9 78
Colorimetric 1×10-9~1.5×10-7 5×10-10 79
Colorimetric 1×10-8~1.5×10-7 3.3×10-9 80
Colorimetric 2×10-9~1×10-7 4.4×10-10 81
Colorimetric — 1×10-5 82
Colorimetric 1×10-5~5×10-3 5×10-5 (in urine)
2×10-4 (in sweat)		 83
SWV 5×10-8~1×10-6 and 1×10-6~3.5×10-5 2.1×10-8 86
SWV — — 87
EIS/DPV 3.3×10-12~3.3×10-9 1.29×10-12 (EIS)
2.22×10-12 (DPV)		 89
EIS 1×10-15~1×10-12 and 1×10-12~1×10-7 3.33×10-16 90
EIS 9×10-11~8.5×10-8 2.9×10-11 91
DPV 3.3×10-10~3.3×10-5 1×10-10 92
SWV 3.3×10-11~3.3×10-6 9×10-12 93
DPV 1×10-11~7×10-11 2.6×10-13 94
DPV 4×10-11~1.5×10-7 1.5×10-11 95
EMPAS 2×10-6~5×10-5 9×10-7 96
EMPAS 5×10-7~5×10-6 3×10-7 97
Interfacial capacitance sensing 1.45×10-14~1.45×10-11 7.8×10-15 98
FET — 1×10-9 99
Conductance change 1×10-9~1×10-5 1×10-9 102
α-HL nanopore 5×10-8~1×10-4 5×10-8 103
Personal glucometer 1×10-8~6×10-7 5.2×10-9 104
LC optical sensor 1×10-9~1×10-5 1×10-9 106
LC optical sensor 1×10-10~1×10-5 — 108
LPFG 2.5×10-5~7.5×10-5 2.5×10-5 109
PIERS 5×10-9~1×10-5 5×10-9 110
ECL 1×10-10~1×10-7 6×10-11 111
图4 基于AuNPs-QD组合体荧光检测可卡因的示意图[72]
Fig. 4 Schematic diagram of fluorescence detection of cocaine based on AuNPs-QD combination[72]
图5 基于CBSAzymes的检测可卡因的原理图[82]
Fig. 5 Schematic diagram of cocaine detection based on CBSAzymes[82]
图6 AuNCs@Zr-MOF作为基底检测可卡因的示意图[89]
Fig. 6 Schematic diagram of AuNCs@Zr-MOF as a substrate to detect cocaine[89]
图7 LC微阵列薄膜检测可卡因的原理图[108]
Fig. 7 Schematic diagram of LC microarray film for detection of cocaine[108]
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摘要

可卡因免疫及适配体生物传感器