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化学进展 2016, Vol. 28 Issue (9): 1341-1350 DOI: 10.7536/PC160422 前一篇   后一篇

• 综述与评论 •

生物传感器在POCT中的应用研究

邓王平, 王丽华, 宋世平, 左小磊*   

  1. 中国科学院上海应用物理研究所 上海 201800
  • 收稿日期:2016-04-01 修回日期:2016-06-01 出版日期:2016-09-15 发布日期:2016-08-16
  • 通讯作者: 左小磊 E-mail:zuoxiaolei@sinap.ac.cn
  • 基金资助:
    国家自然科学基金项目（No.21422508）资助
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Biosensors in POCT Application

Deng Wangping, Wang Lihua, Song Shiping, Zuo Xiaolei*   

  1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
  • Received:2016-04-01 Revised:2016-06-01 Online:2016-09-15 Published:2016-08-16
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 21422508).
即时检测（POCT）是在病人旁边或现场进行的检测，因其简单、快速、便携且不受场所限制已成为目前体外分子诊断技术发展的一支风向标。而生物传感器以其快速、灵敏、高效、便携及易于自动化、微型化等优点在发展现场即时检测技术中具有非常大的潜力。近年来，随着生物传感技术、互联网技术的发展及各种新技术、新方法的兴起和融合，POCT技术和方法得到了实质性发展。本文简要介绍了生物传感器的分类和生物传感器在POCT中的应用现状，综述了近年来各类生物传感器在面向POCT检测应用的研究进展。生物传感器根据类型主要分为基于微流控芯片的生物传感器、基于纸的生物传感器、基于纳米材料的生物传感器、基于手机检测平台的生物传感器及集成的生物传感器等，并对这些传感器平台在POCT检测方面的应用做了阐述，最后对生物传感器在POCT应用中存在的问题进行了讨论，并对其发展趋势及前景做了展望。
关键词： 即时检测, 生物传感器, 微流控芯片, 纸芯片, 手机, 集成型生物传感器
Point-of-care testing (POCT) is a test that performed at or near the site of patient care whenever the medical care is needed, POCT has become an indicator of in vitro diagnosis (IVD) because of its simple, rapid, low cost, portable and without being limited by the place. Biosensors possesses characteristics such as rapid, sensitive, high efficiency, portable and easy to automation and miniaturization, so they have great potential in the development of point-of-care testing technology. In recent years, with the development of the biosensor, internet technology and the rise of new and integrated technology, POCT device has obtained substantial progress. In this review, we first briefly introduced the classification of the biosensors and described the state of the art of biosensors that could be performed in POCT, and then reviewed the representative research progress of biosensors in POCT application.According to the emerging technologies, they are classified into microfluidics based biosensors for POCT,paper based biosensors for POCT, nanomaterials based biosensors for POCT, cell phone based biosensors for POCT and the integrated device for POCT. However, the successful commercialization and widespread implementation of such viable technologies remained subject to several challenges and pending issues. Finally, we discussed the current problems, the future development trend and prospects of biosensors for POCT application.

Contents
1 Introduction
2 Current situation of the biosensor in POCT application
3 Microfluidics based biosensors for POCT
3.1 Optical method based detection
3.2 Electrochemical method based detection
4 Paper-based biosensors for POCT
5 Nanomaterials based biosensors for POCT
6 Cell-phone based platforms for POCT
7 Integrated devices for POCT
8 Conclusion

Key words: point of care test, biosensors, microfluidics, paper chip, cellphone, integrated biosensors

中图分类号: 

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摘要

生物传感器在POCT中的应用研究