• 综述 •
官启潇, 郭和泽, 窦红静. 细胞膜修饰的纳米载体与肿瘤免疫治疗[J]. 化学进展, 2021, 33(10): 1823-1840.
Qixiao Guan, Heze Guo, Hongjing Dou. Nanocarriers Modified by Cell Membrane and Their Applications in Tumor Immunotherapy[J]. Progress in Chemistry, 2021, 33(10): 1823-1840.
纳米载体由于其纳米尺度带来的独特生物功能性,可通过特定设计在生物体内靶向递送各类抗肿瘤药物,具有广泛而重要的应用前景。自肿瘤免疫疗法问世之后,各类纳米载体与肿瘤免疫治疗相结合,逐渐成为提升肿瘤免疫治疗效果的重要手段之一。其中,细胞膜修饰的纳米载体作为一类新型仿生药物载体平台,可使纳米载体获得天然细胞膜的伪装修饰,将细胞膜的特定功能与生物特性转移至纳米载体,使其具有更强的抗免疫清除、血液长循环和肿瘤靶向等特性,同时降低纳米递送系统的免疫原性和细胞毒性,在生物医学应用领域尤其是肿瘤免疫治疗中可发挥更大的作用。本文通过结合免疫治疗的机理,对近年来各种细胞膜修饰纳米载体系统的制备方法、作用机制以及在肿瘤免疫治疗中的应用研究进行综述,并在此基础上对未来的相关探索做出了展望。
分享此文:
[1] |
Couzin-Frankel J. Science, 2013, 342(6165): 1432.
doi: 10.1126/science.342.6165.1432 pmid: 24357284 |
[2] |
Chen D S, Mellman I. Immunity, 2013, 39(1): 1.
doi: 10.1016/j.immuni.2013.07.012 URL |
[3] |
Fontana F, Liu D F, Hirvonen J, Santos H A. Wires Nanomed. Nanobiotechnology, 2017, 9(1): 1421.
|
[4] |
Van Parijs L, Abbas A K. Science, 1998, 280: 243.
pmid: 9535647 |
[5] |
Wu J, Chen J, Feng Y, Zhang S, Lin L, Guo Z, Sun P, Xu C, Tian H, Chen X. Sci. Adv., 2020, 6: eabc7828.
doi: 10.1126/sciadv.abc7828 URL |
[6] |
Li W, Zhang L, Zhang G, Wei H F, Zhao M X, Li H F, Guo S J, Gao J, Kou G, Li B H, Dai J X, Wang H, Guo Y J. Mini Rev. Med. Chem., 2013, 13(5): 643.
pmid: 23469780 |
[7] |
Karmali P P, Simberg D. Expert. Opin. Drug Deliv., 2011, 8(3): 343.
doi: 10.1517/17425247.2011.554818 URL |
[8] |
Xuan M J, Shao J X, Li J B. Natl. Sci. Rev., 2019, 6(3): 551.
|
[9] |
Gulati N M, Stewart P L, Steinmetz N F. Mol. Pharmaceutics, 2018, 15(8): 2900.
doi: 10.1021/acs.molpharmaceut.8b00292 URL |
[10] |
Kroll A V, Fang R H, Zhang L F. Bioconjugate Chem., 2017, 28(1): 23.
doi: 10.1021/acs.bioconjchem.6b00569 URL |
[11] |
Wicki A, Witzigmann D, Balasubramanian V, Huwyler J. J. Control. Release, 2015, 200: 138.
doi: 10.1016/j.jconrel.2014.12.030 URL |
[12] |
Yang Q, Lai S K. Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnology, 2015, 7(5): 655.
|
[13] |
Hu C M J, Zhang L, Aryal S, Cheung C, Fang R H, Zhang L,. PNAS, 2011, 108(27): 10980.
doi: 10.1073/pnas.1106634108 pmid: 21690347 |
[14] |
Fang R H, Kroll A V, Gao W W, Zhang L F. Adv. Mater., 2018, 30(23): 1706759.
doi: 10.1002/adma.v30.23 URL |
[15] |
Fan Z Y, Zhou H, Li P Y, Speer J E, Cheng H. J. Mater. Chem. B, 2014, 2(46): 8231.
doi: 10.1039/C4TB00980K URL |
[16] |
Luk B T, Jack Hu C M, Fang R H, Dehaini D, Carpenter C, Gao W W, Zhang L F. Nanoscale, 2013, 6(5): 2730.
|
[17] |
Zhai Y H, Su J H, Ran W, Zhang P C, Yin Q, Zhang Z W, Yu H J, Li Y P. Theranostics, 2017, 7(10): 2575.
doi: 10.7150/thno.20118 URL |
[18] |
Hu C M J, Fang R H, Wang K C, Luk B T, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen C H, Kroll A V, Carpenter C, Ramesh M, Qu V, Patel S H, Zhu J, Shi W, Hofman F M, Chen T C, Gao W W, Zhang K, Shu C E, Zhang L F. Nature, 2015, 526(7571): 118.
doi: 10.1038/nature15373 URL |
[19] |
Hu Q Y, Qian C G, Sun W J, Wang J Q, Chen Z W, Bomba H N, Xin H L, Shen Q D, Gu Z. Adv. Mater., 2016, 28(43): 9573.
doi: 10.1002/adma.201603463 URL |
[20] |
Liu W, Ruan M L, Wang Y M, Song R G, Ji X, Xu J K, Dai J, Xue W. Small, 2018, 14(38): 1801754.
doi: 10.1002/smll.v14.38 URL |
[21] |
Qin M, Du G S, Sun X. Biomater. Sci., 2020, 8(2): 530.
doi: 10.1039/C9BM01444F URL |
[22] |
Rao L, Wang W B, Meng Q F, Tian M F, Cai B, Wang Y C, Li A X, Zan M H, Xiao F, Bu L L, Li G, Li A, Liu Y L, Guo S S, Zhao X Z, Wang T H, Liu W, Wu J G. Nano Lett., 2019, 19(4): 2215.
doi: 10.1021/acs.nanolett.8b03913 URL |
[23] |
Rao L, Xu J H, Cai B, Liu H Q, Li M, Jia Y, Xiao L, Guo S S, Liu W, Zhao X Z. Nanotechnology, 2016, 27(8): 085106.
doi: 10.1088/0957-4484/27/8/085106 URL |
[24] |
Pierigè F, Serafini S, Rossi L, Magnani M. Adv. Drug Deliv. Rev., 2008, 60(2): 286.
|
[25] |
Zhao Y Z, Jia J, Li Y B, Guo C X, Zhou X Q, Sun Z W. J. Toxicol. Sci., 2014, 39(5): 701.
doi: 10.2131/jts.39.701 URL |
[26] |
Han X, Wang C, Liu Z. Bioconjugate Chem., 2018, 29(4): 852.
doi: 10.1021/acs.bioconjchem.7b00758 URL |
[27] |
Kolesnikova T A, Skirtach A G, Möhwald H. Expert. Opin. Drug Deliv., 2013, 10(1): 47.
doi: 10.1517/17425247.2013.730516 pmid: 23078091 |
[28] |
Guo Y Y, Wang D, Song Q L, Wu T T, Zhuang X T, Bao Y L, Kong M, Qi Y, Tan S W, Zhang Z P. ACS Nano, 2015, 9(7): 6918.
doi: 10.1021/acsnano.5b01042 URL |
[29] |
Matozaki T, Murata Y, Okazawa H, Ohnishi H. Trends Cell Biol., 2009, 19(2): 72.
doi: 10.1016/j.tcb.2008.12.001 pmid: 19144521 |
[30] |
Liang X, Ye X Y, Wang C, Xing C Y, Miao Q W, Xie Z J, Chen X L, Zhang X D, Zhang H, Mei L. J. Control. Release, 2019, 296: 150.
|
[31] |
Song Q L, Yin Y J, Shang L H, Wu T T, Zhang D, Kong M, Zhao Y D, He Y Z, Tan S W, Guo Y Y, Zhang Z P. Nano Lett., 2017, 17(10): 6366.
doi: 10.1021/acs.nanolett.7b03186 URL |
[32] |
Ou W Q, Byeon J H, Soe Z C, Kim B K, Thapa R K, Gupta B, Poudel B K, Ku S K, Yong C S, Kim J O. Theranostics, 2019, 9(23): 6780.
doi: 10.7150/thno.37123 URL |
[33] |
Rao L, Cai B, Bu L L, Liao Q Q, Guo S S, Zhao X Z, Dong W F, Liu W. ACS Nano, 2017, 11(4): 3496.
doi: 10.1021/acsnano.7b00133 URL |
[34] |
Anselmo A C, Modery-Pawlowski C L, Menegatti S, Kumar S, Vogus D R, Tian L L, Chen M, Squires T M, Sen Gupta A, Mitragotri S. ACS Nano, 2014, 8(11): 11243.
doi: 10.1021/nn503732m pmid: 25318048 |
[35] |
Labelle M, Begum S, Hynes R O. Proc. Natl. Acad. Sci. U. S. A., 2014, 111: E3053.
|
[36] |
Dehaini D, Wei X L, Fang R H, Masson S, Angsantikul P, Luk B T, Zhang Y, Ying M, Jiang Y, Kroll A V, Gao W W, Zhang L F. Adv. Mater., 2017, 29(16): 6209.
|
[37] |
Farokhzad O C. Nature, 2015, 526(7571): 47.
doi: 10.1038/nature15218 URL |
[38] |
Mehlen P, Puisieux A. Nat. Rev. Cancer, 2006, 6(6): 449.
|
[39] |
Li J H, Sharkey C C, Huang D T, King M R. Cell. Mol. Bioeng., 2015, 8(1): 137.
|
[40] |
Li J H, Ai Y W, Wang L H, Bu P C, Sharkey C C, Wu Q H, Wun B, Roy S, Shen X L, King M R. Biomaterials, 2016, 76: 52.
doi: 10.1016/j.biomaterials.2015.10.046 URL |
[41] |
Mitchell M J, Wayne E, Rana K, Schaffer C B, King M R. PNAS, 2014, 111(3): 930.
doi: 10.1073/pnas.1316312111 pmid: 24395803 |
[42] |
Kang T, Zhu Q Q, Wei D, Feng J X, Yao J H, Jiang T Z, Song Q X, Wei X B, Chen H Z, Gao X L, Chen J. ACS Nano, 2017, 11(2): 1397.
doi: 10.1021/acsnano.6b06477 URL |
[43] |
Spicer J D, McDonald B, Cools-Lartigue J J, Chow S C, Giannias B, Kubes P, Ferri L E. Cancer Res., 2012, 72(16): 3919.
doi: 10.1158/0008-5472.CAN-11-2393 URL |
[44] |
Watanabe M A E, Oda J M M, Amarante M K, Cesar Voltarelli J. Cancer Metastasis Rev., 2010, 29(4): 569.
doi: 10.1007/s10555-010-9247-y URL |
[45] |
Murdoch C, Giannoudis A, Lewis C E. Blood, 2004, 104(8): 2224.
pmid: 15231578 |
[46] |
Chen H L. J. Gastroenterol. Hepatol., 2013, 28(3): 389.
doi: 10.1111/jgh.12114 URL |
[47] |
Candido J, Hagemann T. J. Clin. Immunol., 2013, 33(1): 79.
|
[48] |
Christie C, Madsen S J, Peng Q, Hirschberg H. Ther. Deliv., 2015, 6(3): 371.
|
[49] |
Qian B Z, Pollard J W. Cell, 2010, 141(1): 39.
doi: 10.1016/j.cell.2010.03.014 URL |
[50] |
Liu R, An Y, Jia W F, Wang Y S, Wu Y, Zhen Y H, Cao J, Gao H L. J. Control. Release, 2020, 321: 589.
doi: 10.1016/j.jconrel.2020.02.043 URL |
[51] |
Chu D F, Dong X Y, Shi X T, Zhang C Y, Wang Z J. Adv. Mater., 2018, 30(22): 1706245.
doi: 10.1002/adma.v30.22 URL |
[52] |
Anderson J M, Rodriguez A, Chang D T. Semin. Immunol., 2008, 20(2): 86.
pmid: 18162407 |
[53] |
Kolaczkowska E, Kubes P. Nat. Rev. Immunol., 2013, 13(3): 159.
doi: 10.1038/nri3399 pmid: 23435331 |
[54] |
Sridharan R, Cameron A R, Kelly D J, Kearney C J, O'Brien F J. Mater. Today, 2015, 18(6): 313.
doi: 10.1016/j.mattod.2015.01.019 URL |
[55] |
Wculek S K, Malanchi I. Nature, 2015, 528(7582): 413.
|
[56] |
Han Y T, Pan H, Li W J, Chen Z, Ma A Q, Yin T, Liang R J, Chen F M, Ma Y F, Jin Y, Zheng M B, Li B H, Cai L T. Adv. Sci., 2019, 6(15): 1900251.
doi: 10.1002/advs.v6.15 URL |
[57] |
Ma W J, Zhu D M, Li J H, Chen X, Xie W, Jiang X, Wu L, Wang G G, Xiao Y S, Liu Z S, Wang F B, Li A, Shao D, Dong W F, Liu W, Yuan Y F. Theranostics, 2020, 10(3): 1281.
doi: 10.7150/thno.40291 URL |
[58] |
Yu G T, Rao L, Wu H, Yang L L, Bu L L, Deng W W, Wu L, Nan X L, Zhang W F, Zhao X Z, Liu W, Sun Z J. Adv. Funct. Mater., 2018, 28(37): 1870265.
doi: 10.1002/adfm.v28.37 URL |
[59] |
Rao L, Bu L L, Cai B, Xu J H, Li A, Zhang W F, Sun Z J, Guo S S, Liu W, Wang T H, Zhao X Z. Adv. Mater., 2016, 28(18): 3460.
doi: 10.1002/adma.201506086 URL |
[60] |
Rao L, Yu G T, Meng Q F, Bu L L, Tian R, Lin L S, Deng H Z, Yang W J, Zan M H, Ding J X, Li A, Xiao H H, Sun Z J, Liu W, Chen X Y. Adv. Funct. Mater., 2019, 29(51): 1905671.
doi: 10.1002/adfm.v29.51 URL |
[61] |
Chen Z, Zhao P F, Luo Z Y, Zheng M B, Tian H, Gong P, Gao G H, Pan H, Liu L L, Ma A Q, Cui H D, Ma Y F, Cai L T. ACS Nano, 2016, 10(11): 10049.
pmid: 27934074 |
[62] |
Fang R H, Hu C M J, Luk B T, Gao W W, Copp J A, Tai Y Y, O'Connor D E, Zhang L F. Nano Lett., 2014, 14(4): 2181.
doi: 10.1021/nl500618u URL |
[64] |
Jin J F, Krishnamachary B, Barnett J D, Chatterjee S, Chang D, Mironchik Y, Wildes F, Jaffee E M, Nimmagadda S, Bhujwalla Z M. ACS Appl. Mater. Interfaces, 2019, 11(8): 7850.
doi: 10.1021/acsami.8b22309 URL |
[65] |
Johnson D T, Kroll A V, Fang R H, Kline J, Zhang L F, Zhang D E. Blood, 2018, 132(Supplement 1): 4062.
doi: 10.1182/blood-2018-99-117841 URL |
[66] |
Kim H Y, Kang M, Choo Y W, Go S H, Kwon S P, Song S Y, Sohn H S, Hong J, Kim B S. Nano Lett., 2019, 19(8): 5185.
doi: 10.1021/acs.nanolett.9b01571 URL |
[67] |
Yang R, Xu J, Xu L G, Sun X Q, Chen Q, Zhao Y H, Peng R, Liu Z. ACS Nano, 2018, 12(6): 5121.
doi: 10.1021/acsnano.7b09041 URL |
[68] |
Fontana F, Shahbazi M A, Liu D, Zhang H, Makila E, Salonen J, Hirvonen J T, Santos H A. Adv. Mater., 2017, 29: 3239.
|
[69] |
Ni J, Song J F, Wang B, Hua H Y, Zhu H H, Guo X Q, Xiong S M, Zhao Y Q. Biomed. Pharmacother., 2020, 126: 110046.
doi: 10.1016/j.biopha.2020.110046 URL |
[70] |
Harris J C, Scully M A, Day E S. Cancers, 2019, 11(12): 1836.
doi: 10.3390/cancers11121836 URL |
[71] |
Kroll A V, Fang R H, Jiang Y, Zhou J R, Wei X L, Yu C L, Gao J, Luk B T, Dehaini D, Gao W W, Zhang L F. Adv. Mater., 2017, 29(47): 1703969.
doi: 10.1002/adma.v29.47 URL |
[72] |
Li S X, Feng X R, Wang J X, Xu W G, Islam M A, Sun T M, Xie Z G, Wang C X, Ding J X, Chen X S. Adv. Funct. Mater., 2019, 29(49): 1970336.
doi: 10.1002/adfm.v29.49 URL |
[73] |
Ye X Y, Mei L. Acta Pharm. Sin., 2019, 54: 1297.
|
[74] |
Ye X Y, Liang X, Chen Q, Miao Q W, Chen X L, Zhang X D, Mei L. ACS Nano, 2019, 13(3): 2956.
doi: 10.1021/acsnano.8b07371 URL |
[75] |
Ochyl L J, Bazzill J D, Park C, Xu Y, Kuai R, Moon J J. Biomaterials, 2018, 182: 157.
doi: 10.1016/j.biomaterials.2018.08.016 URL |
[76] |
Wang Z, Zhang F, Shao D, Chang Z M, Wang L, Hu H Z, Zheng X, Li X Z, Chen F M, Tu Z X, Li M Q, Sun W, Chen L, Dong W F. Adv. Sci., 2019, 6(22): 1970136.
doi: 10.1002/advs.v6.22 URL |
[77] |
Wang H J, Wang K, He L H, Liu Y, Dong H Q, Li Y Y. Biomaterials, 2020, 244: 119964.
doi: 10.1016/j.biomaterials.2020.119964 URL |
[78] |
Xie W, Deng W W, Zan M H, Rao L, Yu G T, Zhu D M, Wu W T, Chen B, Ji L W, Chen L B, Liu K, Guo S S, Huang H M, Zhang W F, Zhao X Z, Yuan Y F, Dong W F, Sun Z J, Liu W. ACS Nano, 2019, 13(3): 2849.
doi: 10.1021/acsnano.8b03788 URL |
[79] |
Chen M S, Chen M, He J T. Artif. Cells Nanomed. Biotechnol., 2019, 47(1): 1635.
doi: 10.1080/21691401.2019.1608219 URL |
[80] |
Hosseinidoust Z, Mostaghaci B, Yasa O, Park B W, Singh A V, Sitti M. Adv. Drug Deliv. Rev., 2016, 106: 27.
|
[81] |
Lim J, Koh V H Q, Cho S S L, Periaswamy B, Choi D P S, Vacca M, de Sessions P F, Kudela P, Lubitz W, Pastorin G, Alonso S. Front. Immunol., 2019, 10: 2737.
|
[82] |
Michalek J, Hezova R, Turanek-Knötigova P, Gabkova J, Strioga M, Lubitz W, Kudela P. Cancer Immunol. Immunother., 2017, 66(2): 149.
doi: 10.1007/s00262-016-1932-4 URL |
[83] |
Paukner S, Stiedl T, Kudela P, Bizik J, Al Laham F, Lubitz W. Expert. Opin. Drug Deliv., 2006, 3(1): 11.
doi: 10.1517/17425247.3.1.11 URL |
[84] |
Bowie A G, Unterholzner L. Nat. Rev. Immunol., 2008, 8(12): 911.
|
[85] |
Chakraborty P, Bhaduri A N, Das P K. Biochem. Biophys. Res. Commun., 1990, 166(1): 404.
doi: 10.1016/0006-291X(90)91959-V URL |
[86] |
Higashi N, Morikawa A, Fujioka K, Fujita Y, Sano Y, Miyata-Takeuchi M, Suzuki N, Irimura T. Int. Immunol., 2002, 14(6): 545.
doi: 10.1093/intimm/dxf021 URL |
[87] |
Iwasaki A, Medzhitov R. Nat. Immunol., 2004, 5(10): 987.
pmid: 15454922 |
[88] |
Roche A C, Midoux P, Pimpaneau V, Nègre E, Mayer R, Monsigny M. Res. Virol., 1990, 141(2): 243.
pmid: 2189173 |
[89] |
Patel R B, Ye M Z, Carlson P M, Jaquish A, Zangl L, Ma B, Wang Y Y, Arthur I, Xie R S, Brown R J, Wang X, Sriramaneni R, Kim K, Gong S Q, Morris Z S. Adv. Mater., 2019, 31(43): 1902626.
|
[90] |
Stuckey D W, Shah K. Nat. Rev. Cancer, 2014, 14(10): 683.
doi: 10.1038/nrc3798 pmid: 25176333 |
[91] |
Aboody K S, Brown A, Rainov N G, Bower K A, Liu S, Yang W, Small J E, Herrlinger U, Ourednik V, Black P M, Breakefield X O, Snyder E Y. PNAS, 2000, 97(23): 12846.
pmid: 11070094 |
[92] |
Ho I A W, Chan K Y W, Ng W H, Guo C M, Hui K M, Cheang P, Lam P Y P. Stem Cells, 2009, 27(6): 1366.
doi: 10.1002/stem.v27:6 URL |
[93] |
Vallabhaneni K C, Tkachuk S, Kiyan Y, Shushakova N, Haller H, Dumler I, Eden G. Cardiovasc. Res., 2011, 90(1): 113.
doi: 10.1093/cvr/cvq362 pmid: 21088115 |
[94] |
Dembinski J L, Wilson S M, Spaeth E L, Studeny M, Zompetta C, Samudio I, Roby K, Andreeff M, Marini F C. Cytotherapy, 2013, 15(1): 20.
doi: 10.1016/j.jcyt.2012.10.003 pmid: 23260083 |
[95] |
Hu Y L, Huang B, Zhang T Y, Miao P H, Tang G P, Tabata Y, Gao J Q. Mol. Pharmaceutics, 2012, 9(9): 2698.
doi: 10.1021/mp300254s URL |
[96] |
Ryu C H, Park S H, Park S A, Kim S M, Lim J Y, Jeong C H, Yoon W S, Oh W I, Sung Y C, Jeun S S. Hum. Gene Ther., 2011, 22(6): 733.
doi: 10.1089/hum.2010.187 URL |
[97] |
Toledano Furman N E, Lupu-Haber Y, Bronshtein T, Kaneti L, Letko N, Weinstein E, Baruch L, Machluf M. Nano Lett., 2013, 13(7): 3248.
doi: 10.1021/nl401376w pmid: 23786263 |
[98] |
Hu Y L, Fu Y H, Tabata Y, Gao J Q. J. Control. Release, 2010, 147(2): 154.
doi: 10.1016/j.jconrel.2010.05.015 URL |
[99] |
Shah K. Adv. Drug Deliv. Rev., 2012, 64(8): 739.
|
[100] |
Gao C Y, Lin Z H, Jurado-Sánchez B, Lin X K, Wu Z G, He Q. Small, 2016, 12(30): 4056.
doi: 10.1002/smll.v12.30 URL |
[101] |
Liu W L, Zou M Z, Liu T, Zeng J Y, Li X, Yu W Y, Li C X, Ye J J, Song W, Feng J, Zhang X Z. Nat. Commun., 2019, 10(1): 1.
doi: 10.1038/s41467-018-07882-8 URL |
[102] |
Marigo I, Dolcetti L, Serafini P, Zanovello P, Bronte V. Immunol. Rev., 2008, 222(1): 162.
doi: 10.1111/j.1600-065X.2008.00602.x URL |
[103] |
Veglia F, Perego M, Gabrilovich D. Nat. Immunol., 2018, 19(2): 108.
doi: 10.1038/s41590-017-0022-x URL |
[104] |
Wu M, Liu X G, Bai H Z, Lai L H, Chen Q, Huang G J, Liu B, Tang G P. ACS Appl. Mater. Interfaces, 2019, 11(10): 9850.
doi: 10.1021/acsami.9b00294 URL |
[105] |
Wang Y C, Luan Z Y, Zhao C Y, Bai C H, Yang K J. Eur. J. Pharm. Sci., 2020, 142: 105136.
doi: 10.1016/j.ejps.2019.105136 URL |
[1] | 陈晓峰, 王开元, 梁芳铭, 姜睿祺, 孙进. 外泌体递药系统及其在肿瘤治疗中的应用[J]. 化学进展, 2022, 34(4): 773-786. |
[2] | 钟琴, 周帅, 王翔美, 仲维, 丁晨迪, 傅佳骏. 介孔二氧化硅基智能递送体系的构建及其在各类疾病治疗中的应用[J]. 化学进展, 2022, 34(3): 696-716. |
[3] | 王欣瑜, 赵富平, 张儒, 孙子茹, 刘胜男, 高清志. 抗肿瘤缺氧诱导因子-1的小分子抑制剂[J]. 化学进展, 2021, 33(12): 2259-2269. |
[4] | 杨强强, 李川, 于淑娴, 范书华, 王月霞, 洪敏. 纳米载体在共负载siRNA及化疗药物对逆转肿瘤多药耐药性方面的应用[J]. 化学进展, 2021, 33(10): 1900-1916. |
[5] | 刘江波, 王丽华, 左小磊. 基于DNA的细胞膜功能化[J]. 化学进展, 2019, 31(8): 1067-1074. |
[6] | 张咚咚, 刘敬民, 刘瑶瑶, 党梦, 方国臻, 王硕. 纳米粒子在药物传递中的应用[J]. 化学进展, 2018, 30(12): 1908-1919. |
[7] | 龚兆翠, 尹超, 赵惠, 卢晓梅, 范曲立, 黄维. 光控纳米载体在药物释放中的应用[J]. 化学进展, 2016, 28(9): 1387-1396. |
[8] | 任天斌, 侠文娟, 吴畏, 李永勇*. 刺激响应型聚合物前药[J]. 化学进展, 2013, 25(05): 775-784. |
[9] | 陈孟婕, 姚晋荣, 邵正中, 陈新. 基于生物大分子的纳米药物载体[J]. 化学进展, 2011, 23(01): 202-212. |
[10] | 李杉杉,何华,焦庆才,Chung,Pham-Huy. 碳纳米管在药物和基因转运领域的研究进展[J]. 化学进展, 2008, 20(11): 1798-1803. |
[11] | 宫铭,杨珊,张世平,宫永宽. 生物医用材料表面仿细胞膜结构改性*[J]. 化学进展, 2008, 20(10): 1628-1634. |
[12] | 黄蕾,赵福群,黄新,张复实. 光免疫偶联物的研究进展*[J]. 化学进展, 2007, 19(04): 527-534. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||