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化学进展 2013, Vol. 25 Issue (11): 1876-1887 DOI: 10.7536/PC130317 前一篇   后一篇

• 综述与评论 •

烯氯化合物及其合成进展

徐立宁, 张军涛, 陶成, 曹小平*   

  1. 兰州大学化学化工学院 功能有机分子化学国家重点实验室 兰州 730000
  • 收稿日期:2013-03-01 修回日期:2013-05-01 出版日期:2013-11-15 发布日期:2013-09-12
  • 通讯作者: 曹小平 E-mail:caoxplzu@163.com
  • 基金资助:

    国家自然科学基金项目(No. 21272098, 21190034,21061160494,J1103307)资助

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Advances in the Synthesis of Vinyl Chloride Compounds

Xu Lining, Zhang Juntao, Tao Cheng, Cao Xiaoping*   

  1. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China
  • Received:2013-03-01 Revised:2013-05-01 Online:2013-11-15 Published:2013-09-12

烯氯常见于天然产物中,并被认为是其生物活性官能团之一,在功能材料方面也多有应用,同时也是有机合成中一类重要的合成子。因而,烯氯的制备方法一直是有机合成化学和制药化学的热点研究内容之一。近年来,制备烯氯的新方法和新试剂不断出现,本文基于不同的反应类型, 对烯氯的构筑方法进行了综述,并列举了海洋天然产物malyngamides全合成中烯氯应用的重要性。

关键词： 有机合成, 烯氯, 天然产物, malyngamides

Vinyl chloride is an important functional group in many biologically and pharmaceutically active compounds, some vinyl chloride derivatives have been employed as organic materials, including polymers, and also are employed as the building block in organic synthesis. The construction of vinyl chloride is widely studied, new method and reagent are continuing to emerge in recently years. In this paper, the recent progress in the synthesis of vinyl chloride is reviewed according to the different reaction types, and its application in the total synthesis of marine natural product malyngamides is covered.

Contents
1 Introduction
2 Synthesis of vinyl chloride by Wittig reaction
3 Cr,Pd,Ti,In,Mg,and Cu-mediated reaction to synthesize vinyl chloride
3.1 Organic Cr-mediated reaction
3.2 Pd-mediated reaction
3.3 Ti-mediated reaction
3.4 In-mediated reaction
3.5 MgCl2-mediated reaction
3.6 Cu-mediated reaction
4 Using other methods to synthesize vinyl chloride
5 Studied on the synthesis of vinyl chloride and applied in marine natural product malyngamides
5.1 Synthesis of vinyl chloride by Wittig reaction in malyngamides M, O, P, Q, R
5.2 Synthesis of vinyl chloride by the reaction of n-Bu4NI with 1,2-dichloroethane in malyngamides K, L, 5-epi-C
6 Conclusion

Key words: organic synthesis, vinyl chloride, natural product, malyngamides

中图分类号: 

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烯氯化合物及其合成进展