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Research Progress of Nanofiber Composite Hydrogels
Yvqing Ma, Zheng Li, Guobao Zheng, Songnan Zhang, Jixian Gong, Changsheng Qiao
Progress in Chemistry, 2024, 36(10): 1594-1606.   DOI: 10.7536/PC240305

Nanofiber Hydrogel material Features & Applications Ref
Cellulose nanofibers
(CNF)
Gelatine (Gel); Gelatinized methacrylate (GelMA) 3D bioprinting of biomedical scaffolds.
Modulation of gelatin gel properties with potential application in gelatin food additives
32,33
Bacterial cellulose nanofiber (BC-f) Polyacrylamide (PAM) composite hydrogels; Poly(γ-glutamic acid) (γ-PGA) hydrogel High mechanical properties with great potential for wound dressings and biomedical applications.
High mechanical strength, on-demand drug release, smart drug delivery patch
34,35
Polylactic acid (PLA) nanofiber GelMA Alginate (Alg)-hyaluronic acid (HA) hydrogel (Alg-HA) Providing a suitable microenvironment for bone tissue engineering repair.
Meet the mechanical properties of cartilage tissue, no cytotoxicity, suitable for chondrocyte migration.
36,37
Polycaprolactone (PCL) nanofiber Gelatin-based hydrogel;
Composite hydrogel
3D hybrid scaffolds are mimicking natural heart tissue structures.
Bone regeneration in bone repair in clinical therapy
38,39
Aramid nanofiber (ANF) polyvinyl alcohol (PVA) Implantable tissue prosthetics, tendon-mimetic hydrogels, flexible Electronic Sensors 10,40
Silicon dioxide (SiO2) nanofiber Vinylsilane/Sodium/Alginate/
Polyacrylamide composite hydrogel; Siloxane-derived hydroxy propyl methyl cellulose composite hydrogel
Bionic electronic sensors with high mechanical strength.
Injectable materials for minimally invasive cartilage surgery
25,41
Carbon nanofiber powder (CFP) Alginate (Alg) based hydrogels New biomaterial for bone tissue engineering scaffolds,
topical drug-delivery carriers
42,43
Hydroxyapatite nanofiber (HANF) GelMA Great potential for application in tissue engineering. 44
Organic-inorganic hybrid nanofiber
Chitosan (CS) hydrogel; GelMA Good anti-scaling properties, filtration of dyes in wastewater.
Self-assembly of nanofibers within hydrogels for applications in biomimetic scaffolds
45,46
Table 1 Nanofiber composite hydrogel classification and applications
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