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化学进展 2022, Vol. 34 Issue (9): 1882-1895 DOI: 10.7536/PC211206 前一篇   后一篇

• 综述 •

二苯丙氨酸二肽微纳米结构的可控组装及应用

王克青1,2, 薛慧敏1, 秦晨晨1,*(), 崔巍1,*()   

  1. 1 中国科学院化学研究所 北京 100190
    2 中国国家博物馆 北京 100006
  • 收稿日期:2021-12-06 修回日期:2022-02-08 出版日期:2022-09-20 发布日期:2022-04-01
  • 基金资助:
    国家自然科学基金项目(21961142022); 国家自然科学基金项目(21872150); 国家自然科学基金项目(22072160)
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Controllable Assembly of Diphenylalanine Dipeptide Micro/Nano Structure Assemblies and Their Applications

Keqing Wang1,2, Huimin Xue1, Chenchen Qin1(), Wei Cui1()   

  1. 1 Institute of Chemistry, Chinese Academy of Sciences,Beijing 100190, China
    2 National Museum of China,Beijing 100006, China
  • Received:2021-12-06 Revised:2022-02-08 Online:2022-09-20 Published:2022-04-01
  • Contact: *e-mail: cuiwei@iccas.ac.cn(Wei Cui);gracecc1989@163.com(Chenchen Qin)
  • Supported by:
    National Natural Science Foundation of China(21961142022); National Natural Science Foundation of China(21872150); National Natural Science Foundation of China(22072160)

近年来,生物组装单元构筑微纳米结构的组装体在生物纳米技术等领域得到了广泛的研究。不同形貌的微纳米组装体可以通过生物分子的自组装这样快速、简便的方法获得。在众多肽基构筑基元中,二苯丙氨酸二肽及其衍生物作为一种生物活性的肽,具有生物兼容性好、容易化学修饰/生物功能化、制备简单等特点,是构筑微纳米结构材料时重要的生物基元之一。通过可控的方法组装,可以得到基于二苯丙氨酸及其衍生物的不同结构的组装体,他们在光学、机械工程、电化学传感检测等方面也具有广阔的应用前景。研究证明通过改变组装条件以及引入外源小分子等方法可以实现调控短肽的分子组装。本文综述了二苯丙氨酸二肽微纳米组装体的可控组装及他们在生物医学、生物传感、光电材料、光波导和催化等方面的应用。

关键词： 分子组装, 二苯丙氨酸二肽, 生物医学, 生物传感, 光电材料

In recent years, the construction of micro/nano structure assemblies by biological assembly units has been extensively studied in the fields of bio-nanotechnology and other fields. Micro/nano structure assemblies with different morphologies can be obtained by a quick and simple method such as the self-assembly of biomolecules. Diphenylalanine dipeptide and its derivatives, as a biologically active peptide in many peptide-based building blocks, have good biocompatibility and characteristic for chemical modification, biological function and simple preparation. Micro/nano-materials with different structures based on diphenylalanine and its derivatives can be obtained by controllable assembled methods. They also have wide applications in optics, mechanical engineering, electrochemical sensing and detection areas, etc. Controlled assembly of short peptides and its derivatives can be achieved by changing the assembly conditions or introducing of exogenous small molecules. This review summaries and outlooks the controllable assembly of diphenylalanine dipeptide micro/nano structure assemblies and their applications in biomedicine, biosensor, optoelectronic materials, optical waveguides and catalysis.

Contents

1 Introduction

2 Controllable assembly of dipeptide-based assemblies

2.1 Physical factors

2.2 Chemical factors

2.3 Biological factors

3 Application of dipeptide-based assemblies

3.1 Biomedicine

3.2 Biosensors

3.3 Optoelectronic materials

3.4 Optical waveguide

3.5 Catalysis

4 Conclusion and outlook

Key words: molecule assembly, diphenylalanine dipeptide, biomedicine, biosensor, optoelectronic materials
()
图1 手性Ferrocene-L-Phe-L-Phe-OH (Fc-FF)组装成手性纳米结构的示意图[36]
Fig. 1 Chiral self-assembly of Ferrocene-L-Phe-L-Phe-OH (Fc-FF) into rationally designed chiral nanostructures[36]
图2 光调控的二肽超分子凝胶-溶胶可逆转变[40]
Fig. 2 Representation of light-controlled reversible gel-sol transition of non-photosensitive diphenylalanine supramolecular assembly[40]
图3 金属离子诱导的Fmoc-FF组装体从β-折叠到超螺旋和无规卷曲的结构转变示意图[15]
Fig. 3 Schematic illustration of the metal ion modulated structural transformation of amyloid-derived self-assembled Fmoc-FF from the β-sheet into the superhelix and random coil[15]
图4 (a) Fmoc-FF形成的水凝胶的宏观和微观表征;(b) Ulijn等[60]提出的自组装水凝胶中Fmoc-FF 的分子排列模型
Fig. 4 (a) Macroscopic and microscopic characterization of gel formed by Fmoc-FF hydrogelator; (b) Packing model of Fmoc-FF dipeptides in self-assembled hydrogels as proposed by Ulijn et al.[60]
图5 气凝胶和冰凝胶分别作为止血材料和防水材料用于体外创伤治疗[77]
Fig. 5 Use of FF aerogels as hemostasis materials and cryogels as waterproof materials for wound care[77]
图6 制备CDP-AuNP杂化微球及ChOx/CDP-AuNP/CS/PB修饰电极示意图[88]
Fig. 6 Schematic process of assembling CDP-AuNP hybrid microspheres and fabrication of ChOx/CDP-AuNP/CS/PB biosensor electrodes[88]
图7 纳米管压电材料的制备[90]
Fig. 7 Preparation of FF nanotube piezoelectric materials[90]
图8 (a) CDP和京尼平的结构及不同溶剂调控下CDPG的组装;(b) 纳米球和纳米纤维修饰的光阳极的光电流测试[94]
Fig. 8 (a) Chemical structures of CDP and genipin and solvent-modulated assembly of CDPG; (b) schematic of the photocurrent measurements with the photoanodes based on nanospheres and nanofibers[94]
图9 (a~c) 罗丹明B掺杂的二苯丙氨酸(FF)枝化结构激光共聚焦图像及(d)明场图像; FF-RhB枝化结构的(e~g)光波导照片和(h)明场照片,标尺为 20 μm[98]
Fig. 9 (a~c) CLSM images and (d) bright-field image of rhodamine B doped diphenylalanine branched structure. (e, f) Photoluminescence images of rhodamine B-doped diphenylalanine branched structures excited at the rod position. (g) Photoluminescence image and (h) bright-field image of rhodamine B-doped diphenylalanine branched structures excited at the tips of the branches. All the scale bars represent 20 μm[98]
图10 (A) 天然漆酶的结构式以及(B) 二肽基超分子装配体在Cu2+和H+的调控下可逆转化及催化过程的示意图[33]
Fig.10 (A) Highlighted crystal structure of fungus laccase from Trametes versicolor (PDB: 1GYC). (B) Chemical structure of CDPGA, schematic illustration of reversible transformation of nanospheres to nanochains modulating by Cu2+ and H+, and switchable enzyme-like catalytic oxidation of hydroquinone to benzoquinone[33]
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