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化学进展 2015, Vol. 27 Issue (2/3): 220-228 DOI: 10.7536/PC140810 前一篇   后一篇

• 综述与评论 •

纳米羟基磷灰石/聚合物复合骨修复材料

廖建国*, 李艳群, 段星泽, 朱伶俐   

  1. 河南理工大学材料科学与工程学院 环境友好型无机材料河南省重点实验室培育基地 焦作 454000
  • 收稿日期:2014-08-01 修回日期:2014-11-01 出版日期:2015-03-15 发布日期:2014-12-22
  • 通讯作者: 廖建国 E-mail:liaojianguo10@hpu.edu.cn
  • 基金资助:

    国家自然科学基金项目(No.U1304820),河南省教育厅基础研究计划(No.13A430331)和河南理工大学博士基金项目(No.B2009-36)资助

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Nano-Hydroxyapatite/Polymer Composite as Bone Repair Materials

Liao Jianguo*, Li Yanqun, Duan Xingze, Zhu Lingli   

  1. Cultivating Base for Key Laboratory of Environment-Friendly Inorganic Materials in Henan Province, School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo 454000, China
  • Received:2014-08-01 Revised:2014-11-01 Online:2015-03-15 Published:2014-12-22
  • Supported by:

    The work was supported by the National Natural Science Foundation of China (No. U1304820), the Education Department of Henan Province Basic Research Program(No. 13A430331) and the Doctoral Program of Henan Polytechnic University (No. B2009-36).

寻找理想的骨修复材料一直是骨科材料领域研究热点。自然骨是由纳米羟基磷灰石和胶原构成的纳米复合材料。源于仿天然硬组织构想的纳米磷灰石-有机高分子复合材料是把高韧性的高分子基质与高刚性的纳米无机磷灰石晶体巧妙结合,使其最大程度地实现两种成分的优势互补和协同优化,赋予仿生纳米复合材料高强韧的力学性能。与组成同样重要的是结构因素,这种材料包括不同尺寸的架构组织和可控取向。纳米羟基磷灰石/高分子复合材料已成为骨组织修复材料领域的研究热点和发展方向。本文综述了近些年用于人体骨组织修复材料的纳米羟基磷灰石/天然(或非天然)高分子材料的制备技术、性能等方面研究进展及现状,并对其发展提出了展望。

关键词： 纳米羟基磷灰石, 骨修复, 聚合物, 复合材料

The searching of ideal bone repair materials has always been one of research hot spots in the field of orthopedics. Natural bones are nanocomposites mainly composed of nano-hydroxyapatite and collagen. Nano-hydroxyapatite/polymer composites, derived from imitation of natural hard tissue, combine polymer matrix with high toughness and nano-hydroxyapatite crystals with high rigidity. These nanocomposites have high toughness since they maximize the complementary advantages. Structure factors are equally important to composition for the high performance of these composites, which include architectural organization and controlled orientation in different dimensions. Nano-hydroxyapatite/polymer composite materials have become a research hot spot and development direction in the field of bone tissue repair materials. This paper summarizes the research progress and status in the aspects of preparation and properties of these materials used for the repair of body hard tissue, and predicts its future development.

Contents
1 Introduction
2 Nano-hydroxyapatite/natural polymer composites
2.1 Nano-hydroxyapatite/collagen composite
2.2 Nano-hydroxyapatite/silk fibroin composite
2.3 Nano-hydroxyapatite/chitosan composite
3 Nano-hydroxyapatite/synthetic polymer composites
3.1 Nano-hydroxyapatite/polylactic acid composite
3.2 Nano-hydroxyapatite/polyamide composite
3.3 Nano-hydroxyapatite/polyethylene composite
3.4 Nano-hydroxyapatite/other polymer composites
4 Conclusion and outlooks

Key words: nano-hydroxyapatite, bone repair, polymers, composites

中图分类号: 

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