Loading...
中文
Earlier issues
Announcement
More
Progress in Chemistry 2002, No.04 Previous issue Next issue

In this issue:

Review
Progress in the Recognition and Repairof DNA Damage
Chen Huili,Yang Pin**
2002, 14 (04): 239- |
Published: 24 July 2002
PDF ( 2329 ) Save Cited
Abstract
Recent progress in chemical models that can recognize and repair DNA damage is reviewed. These studies are helpful for elucidating the mechanisms of DNA recognition and repair, and the design of novel .synthetic nucleases.
Studies on Transmembrane Transportation of Rare Earths by Fluorescence and Patch-Clamp Methods
Wei Chunying,Yang Pin**
2002, 14 (04): 246- |
Published: 24 July 2002
PDF ( 1357 ) Save Cited
Abstract
This review presents the studies of transmembrane transportation of rare earths in China. The focuses are especially on the florescence and patch-clamp methods. The perspective in this research field is also discussed.
Application of Patch-Clamp Technique in Life Chemistry
Yang Pin,Du Huizhi,Xue Shaowu
2002, 14 (04): 251- |
Published: 24 July 2002
PDF ( 2408 ) Save Cited
Abstract
As an advanced electrophysiological technique, the patch-clamp technique has become one of the most important methods in the research field of life sciences. It is more powerful when combining with other techniques, such as the fura-2 microfluorometry (for measuring the concentration of Ca2+) and single-cell reverse transcription of RNA followed by the polymerase chain reaction (RT-PCR). In this article, the general mechanism and the models of the patch-clamp technique and its applications to life chemistry are summarized.
Metals in Biology and Medicine
Sun Hongzhe,Chen Rong,Che Chiming*
2002, 14 (04): 257- |
Published: 24 July 2002
PDF ( 3632 ) Save Cited
Abstract
Metals are necessary for normal function of cells and the survival of organisms. The abnormal interactions between metal ions and macromolecules (such as protein, DNA and RNA, etc. ) and nerve system can damage DNA and cells, and hence cause diseases. Understanding of these interactions offers potentials for the discovery of novel therapeutic and diagnostic agents and also improves the knowledge about diseases that are currently intractable. Several metals and inorganic medicines are also reviewed.
The Influences of Metal Ions on Protein Folding, Recognition, Self-Assembly and Biological Functions
Jiang Ming,Shen Tao,Xu Huibi,Liu Changlin**
2002, 14 (04): 263- |
Published: 24 July 2002
PDF ( 5013 ) Save Cited
Abstract
Metal ions and their complexes can exert influences on not only three-dimensional structures of proteins, but also biomacromolecular recognition, self-assembly and functions. The metal ions or their complexes can act as templates that mediate the peptide chains around to fold them into correct structures, which is designated as template-mediated structural motif (TMSM). It is of great significance for the bioinorganic chemists to understand the roles of metal ions in the self-assembly of protein-DNA/RNA and biomacromolcular cross-linking and aggregation states.
ADME/Tox Approach in Inorganic Medicinal Chemistry
Yang Xiaoda,Yang Xiaogai
2002, 14 (04): 273- |
Published: 24 July 2002
PDF ( 1640 ) Save Cited
Abstract
High throughput techniques and computer models are widely used in the absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) studies of drugs. Study of metal complexes and other inorganic compounds via the approach of ADME/Tox is a novel, active, and promising research area. The absorption, transport, cellular uptake, and metabolism of iron and copper currently received more attentions and some of the mechanisms were elucidated. The across membrane transportation of lanthanide ions was found to be through multiple pathways. Advances in the ADME/Tox research of other inorganic compounds were also reviewed.
Biological Effects of Vanadium and Its Potential for Pharmaceutical Applications-The Chemical Issues in the Studies on Metal Drugs
Yang Xiaogai,Yang Xiaoda,Wang Kui*
2002, 14 (04): 279- |
Published: 24 July 2002
PDF ( 2956 ) Save Cited
Abstract
In light of the analogy in chemical and biological behavior between non-essential ions and essential ions, the chemical species of vanadium compounds under physiological condition and their physical-chemical characters, which are important for the biological effects are reviewed. The mechanisms of hypoglycemic activity of insulin-mimic vanadium compounds and development of anti-diabetes drugs are also introduced.
The Functions of Transferrin and Its Receptor with Lanthanides and Other Metal Ions
Yang Binsheng,Feng Jiuying
2002, 14 (04): 287- |
Published: 24 July 2002
PDF ( 1607 ) Save Cited
Abstract
Recent progress on the regulation functions of transferrin and its receptor in iron utilization was summarized. The studies on the complexes formed between transferrin and lanthanide ions, receptor-mediated endocytosis of terbium-transferrin in K562 cell were briefly reviewed.
Coordination Chemistry in Neurobiology
Liu Qin,Zhang Junyong,Guo Zijian**,Tang Wenxia
2002, 14 (04): 292- |
Published: 24 July 2002
PDF ( 1449 ) Save Cited
Abstract
There is no doubt that neuroscience is among the most attractive research areas in this new century. The importance of metals in the brain is appreciated more and more by neuroscientists. In this paper the recent advances of the metallo-chemistry in the neuroscience from the perspective of coordination chemistry are summarized. The emphasis is on the correlation between neurodegenerative diseases and metal ions.
Progress of Ruthenium-Based Antitumor Complexes
Wang Zhongming,Ji Liangnian**
2002, 14 (04): 296- |
Published: 24 July 2002
PDF ( 2308 ) Save Cited
Abstract
The antitumor activity, hydrolysis, binding characters to DNA and proteins of ruthenium complexes are briefly reviewed.
The Signal Transduction in ROS-Mediated Apoptosis Induced by Selenium Compounds
Xu Huibi,Yang Xiangliang,Liu Qiong,Wang Haitao,Gan Lu
2002, 14 (04): 305- |
Published: 24 July 2002
PDF ( 1840 ) Save Cited
Abstract
The biological function of selenium in preventing cancer can be explained by inducing apoptosis of tumor cells. This is an interdisciplinary frontier of the bioinorganic chemistry of selenium and its related subjects. Based on the newest studies and the authors' research results, the mechanism of signal transduction in ROS-mediated apoptosis induced by selenium compounds is introduced, the characters of ROS as signal molecules and the chemical bases of the interactions between selenium compounds and ROS are elaborated.
Recent Progress in the Carbonic Anhydrase and Its Models
Mao Zongwan,Ji Liangnian
2002, 14 (04): 311- |
Published: 24 July 2002
PDF ( 2705 ) Save Cited
Abstract
The recent progress in carbonic anhydrase and its models is reviewed. A brief discussion about the problems and the further research is also given.
New Trends in Metalloprotein Studies
Huang Zhongxian
2002, 14 (04): 318- |
Published: 24 July 2002
PDF ( 3307 ) Save Cited
Abstract
Some new trends in the study of metalloproteins and metalloenzymes have been described from aspects of metal ions-related diseases (especially the neurodegenerative diseases), the roles of metal ions in folding, aggregation and assembly of proteins, the design and reconstruction of metallochaperons and metalloproteins, interactions between metalloproteins and DNA.