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Progress in Chemistry 2002, Vol. 14 Issue (04): 305- Previous Articles   Next Articles

• Review •

The Signal Transduction in ROS-Mediated Apoptosis Induced by Selenium Compounds

Xu Huibi;Yang Xiangliang;Liu Qiong;Wang Haitao;Gan Lu   

  1. Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China
  • Received: Revised: Online: Published:
  • Contact: Xu Huibi
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The biological function of selenium in preventing cancer can be explained by inducing apoptosis of tumor cells. This is an interdisciplinary frontier of the bioinorganic chemistry of selenium and its related subjects. Based on the newest studies and the authors' research results, the mechanism of signal transduction in ROS-mediated apoptosis induced by selenium compounds is introduced, the characters of ROS as signal molecules and the chemical bases of the interactions between selenium compounds and ROS are elaborated.
Key words: selenium, ROS, apoptosis, signal transduction

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