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Progress in Chemistry 2002, Vol. 14 Issue (04): 273- Previous Articles   Next Articles

• Review •

ADME/Tox Approach in Inorganic Medicinal Chemistry

Yang Xiaoda;Yang Xiaogai   

  1. Department of Chemical Biology, School of Pharmaceutical Sciences; National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China
  • Received: Revised: Online: Published:
  • Contact: Yang Xiaoda
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High throughput techniques and computer models are widely used in the absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) studies of drugs. Study of metal complexes and other inorganic compounds via the approach of ADME/Tox is a novel, active, and promising research area. The absorption, transport, cellular uptake, and metabolism of iron and copper currently received more attentions and some of the mechanisms were elucidated. The across membrane transportation of lanthanide ions was found to be through multiple pathways. Advances in the ADME/Tox research of other inorganic compounds were also reviewed.
Key words: inorganic pharmaceutics, ADME/Tox, pharmacokinetics, pharmaceutical chemistry, metal ions

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