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Progress in Chemistry 2020, Vol. 32 Issue (2/3): 331-343 DOI: 10.7536/PC190332 Previous Articles   Next Articles

Biomedical Functional Polymer Based on PHPMA

Fenming Zhang1,2,3, Yushu Tian3, Ji Zheng3, Kun Chen3, Anchao Feng1,2,3,**(), Liqun Zhang1,2,3   

  1. 1. State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijng 100029, China
    2. Beijing Key Laboratory of preparation and processing of new polymer materials, Beijing University of Chemical Technology, Beijing 100029, China
    3. College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
  • Received: Online: Published:
  • Contact: Anchao Feng
  • About author:
    ** e-mail:
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Poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA), a water soluble polymer bearing a stable structure, can be metabolized in the human body. Because of that, PHPMA is widely used in anticancer drug’s delivery systems. The drug delivery systems based on the PHPMA have been extensively studied over the past few decades. Scientists use different kinds of functional groups to modify the polymer, which can deliver drugs to targeted tissue or detect pathogenic tissue. In recent studies, scientists enhance the degradability of the polymer and decrease the cytotoxicity, which makes the delivery system based on PHPMA more suitable to be utlized in human body. In this paper, we summarize the recent works about PHPMA and studies of different methods to modify the polymer with drugs or functional groups.

Key words: poly(N-(2-hydroxypropyl)methacrylamide)(PHPMA), water soluble polymer, drug carrier
Scheme 1 Scheme 1 Synthesis of HPMA based polymers bearing thiol end groups for radioactive labeling with 72/74As [10]
Scheme 2 Scheme 2 Synthesis of copolymer of HPMA and allyl methacrylate (AMA) via RAFT and subsequent conjugation with thiolated α(1,2)-trimannoside using thiol-ene chemistry [16]
Fig.1 Molecular structure of the PBS/PBDL copolyester-left, PHPMA-chol-middle and PHPMA-chol-DOX-right (top) and schematic representation of the prepared NPs (bottom) (PBS/PBDL-black, PHPMA-blue, cholesterol anchor-yellow, DTXL-green, and DOX-red) [20]
Fig.2 Illustration of acid-specific intracellular backbone degradation and release of doxorubicin (DOX) from cross-linked micelles of HPMA copolymers containing β-sitosterol (β-SITO) [22]
Fig.3 Schematic illustration for the fabrication of multifunctional micellar nanoparticles [23]
Scheme 3 Scheme 3 Synthetic scheme of HPMA copolymer-PTX conjugates. (A) Synthesis of traditional HPMA copolymer-paclitaxel conjugate (P-PTX). (B) Synthesis of multiblock backbone biodegradable HPMA copolymer-paclitaxel conjugate (mP-PTX) [25]
Fig.4 (A) SPECT/CT imaging of mice bearing orthotopic A2780 human ovarian carcinoma after intravenous injection of 125I-labeled P-PTX or mP-PTX. L, liver; S, spleen; B, bladder; T, tumor. (B) Photographs of tumors after treatment with different PTX formulations [25]
Scheme 4 Scheme 4 Structures of HPMA copolymer TAT conjugates [27]
Fig.5 Kinetics of DOX in the blood and tumour after i.v. administration of HPMA copolymer-DOX conjugates. (A) Accumulation of DOX in tumour tissue; (B) Blood clearance of DOX; (C) Tumour to blood ratio[37]
Scheme 5 Scheme 5 Synthetic scheme for P-SS-Mce6 [39]
Scheme 6 Synthesis of reducible HPMA-co-oligolysine copolymers via reversible-addition fragmentation chain transfer (RAFT) polymerization [41]
Fig.6 Synthesis of nano-capsules using gold nanoparticles, (1) assembly of nanoparticles, (2) crosslinking, (3) removal of GNP cores [42]
Fig.7 Using miniemulsion periphery RAFT polymerization (IMEPP) approach to prepare hollow polymeric nanoparticles [43]
Fig.8 (A) Schematic illustration of the structure of the proposed noncovalent poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA)- based polymer therapeutics. (B) Envisioned pathway for the cell uptake of the proposed noncovalent polymer therapeutics and subsequent intracellular release of the cargo. In this illustration, the drug is represented by a red star [45]
Fig.9 (a) synthesis of (CCK)-Polymer; (b) synthesis of Fab’-(CCE) [46]
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