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Progress in Chemistry 2016, Vol. 28 Issue (9): 1397-1405 DOI: 10.7536/PC160423 Previous Articles   Next Articles

• Review and comments •

Enhancement of Intra-Tumor Penetration and Distribution of Nano-Drug Carriers

Han Donglin1, Qi Hongzhao1, Zhao Jin1, Long Lixia1, Ren Yu2, Yuan Xubo1*   

  1. 1. Tianjin Key Laboratory of Composite & Functional Materials, School of Materials Science & Engineering, Tianjin University, Tianjin 30007;
    2. Basic Medical Research Center, Tianjin Medical University, Tianjin 300070, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No. 51303125,51473119).
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The tumor therapeutics effect of chemotherapeutant, proteins and genes could be improved when they are loaded in nano-drug carriers. But in some cases the therapeutics effects are modest due to the poor penetration and distribution of nano-carriers in the heterogeneous tumor tissue. During the recent years, increasing efforts have been dedicated to improve the intra-tumor penetration by controlling the size, surface zeta potential, targeting agents, and shape of nano-drug carriers. This paper reviews the progress in enhancement of intra-tumor penetration and distribution of nano-drug carriers through the modification of their components, structures and physicochemical properties. The challenges of nano-drug carriers in tumor treatment are raised and the possible solutions are proposed.

Contents
1 Introduction
2 Inorganic nano-drug carriers
2.1 Meso-porous silicon nano-drug carriers
2.2 Gold nano-drug carriers
3 Organic nano-drug carriers
3.1 Micelles
3.2 Dendrimers
3.3 Liposomes
3.4 Polymer nanocapsule
4 Conclusion

Key words: nano-drug carriers, physicochemical properties, tumor, penetration, microscopic distribution

CLC Number: 

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