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Progress in Chemistry >

2025 0

DOI: https://doi.org/10.7536/PC240815

Original article

Construction and Application of ONOO− Small Molecule Fluorescent Probes in Pathophysiological Processes

  • Ting Ma 1, 2, 3 ,
  • Chunyu Deng 1, 2, 3 ,
  • Jie Li 1, 2, 3 ,
  • Zhouyu Wang , 1, 2, 3, * ,
  • Qian Zhou 1, 2, 3, * ,
  • Xiaoqi Yu , 1, 2, 3, *
Expand
  • 1 School of Science, Xihua University
  • 2 Sichuan Engineering Research Center for Molecular Targeted Diagnostic & Therapeutic Drugs
  • 3 Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Chengdu, 610039, China
* Corresponding author e-mail: （Zhou-Yu Wang）；zhouq@mail.xhu.edu.cn（Qian Zhou）；xqyu@scu.edu.cn（Xiao-Qi Yu）

Received date: 2024-09-04

  Revised date: 2025-01-20

  Online published: 2025-03-19

Supported by

the National Natural Science Foundation of China(22307104)

Sichuan Science and Technology Program(2023NSFSC0637)

Sichuan Science and Technology Program(2023NSFSC1977)

Fold

Abstract

ONOO−, produced by the diffusion-controlled reaction of nitric oxide and superoxide radicals, is a strong oxidizing and nitrating agent that causes damage to DNA, proteins, and other biomolecules in cells. Since ONOO− is characterized by its short lifetime, high reactivity, and low concentration under physiological conditions, and the pathophysiological roles it plays in biological systems are not yet fully understood, it is of great significance to develop highly sensitive and selective detection technologies to achieve real-time dynamic monitoring of ONOO−. In this paper, we review the research progress of ONOO− fluorescent probes in disease-related processes in the recent 5 years, revealing the potential role of ONOO− in various diseases, such as inflammation, tumors, liver injury, and brain diseases. Finally, the bottlenecks in the development of ONOO− probes and future trends are discussed, which will promote the application of ONOO− probes in chemistry, biology, and pharmacology.

Contents

1 Introduction

2 Design strategy of ONOO− fluorescent probe

3 Detection and imaging of ONOO− by fluorescent probes in disease-related processes

3.1 Detection and imaging of ONOO− in inflammation

3.2 Detection and imaging of ONOO− in tumors

3.3 Detection and imaging of ONOO− in Liver Injuries

3.4 Detection and Imaging of ONOO− in Brain diseases

3.5 Detection and imaging of ONOO− in other disease models

4 Conclusion and outlook

Key words： fluorescence imaging; peroxynitrite; tumor; liver injury; neurodegenerative disease

Cite this article

Ting Ma , Chunyu Deng , Jie Li , Zhouyu Wang , Qian Zhou , Xiaoqi Yu . Construction and Application of ONOO− Small Molecule Fluorescent Probes in Pathophysiological Processes[J]. Progress in Chemistry, 2025 . DOI: 10.7536/PC240815

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