中文
Earlier issues
Announcement
More
Progress in Chemistry 2009, Vol. 21 Issue (05): 1052-1059 Previous Articles   Next Articles

• Review •

Development of Electrochemical DNA Biosensors

Huang Qiang; Liu Hongying; Fang Bin**   

  1. (Anhui Key Laboratory of Chemo-Biosensing, School of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China)
  • Received: Revised: Online: Published:
  • Contact: Fang Bin E-mail:binfang_47@yahoo.com.cn
PDF ( 2491 ) Cited
Export

EndNote

Ris

BibTeX

Owing to the advantages of its high sensitivity, rapid response, easy handling, and low cost, the electrochemical DNA biosensor has received much attention in the field of genic sequence detection and has gradually become an important field in the study of molecular biology and biological research. Electroactive molecules and nano materials have been applied into the electrochemical DNA biosensors because of their special properties. Here, the principle and classification of the electrochemical DNA biosensors are introduced, and the applications of electroactive molecules and nano materials in electrochemical DNA biosensors in recent years are reviewed. A prospect for the future development in this field is also briefly given.

Contents
1 Principle of electrochemical DNA biosensors
2 The applications of electroactive molecules in electrochemical DNA biosensors
2.1 Non-labeling hybridization indicator as recognition element
2.2 Labeling hybridization indicator as recognition element
3 The applications of nano materials in electrochemical DNA biosensors
3.1 Use of metal nanoparticles
3.2 Use of semiconductor- and oxide- nanoparticles
3.3 Use of magnetic microspheres
3.4 Use of other nano materials
4 Outlook

Key words: electrochemical DNA biosensors, electroactive molecules, nano materials

CLC Number: 

[ 1 ] 　Vercoutere W, Akeson M. Cur. Opin. Chem. Biol . , 2002 , 6 :816 —822
[ 2 ] 　Thorp H H , March T. Trends Biotechnol . , 1998 , 16 : 117 —121
[ 3 ] 　Palecek E. Nature , 1960 , 188 : 656 —657
[ 4 ] 　马丽(Ma L) , 白燕(Bai Y) , 刘仲明(Liu Z M) , 刘芳(Liu F) .传感器技术(Journal of Transducer Technology) , 2002 , 21 : 58 —61
[ 5 ] 　汪庆祥(Wang Q X) , 袁显龙(Yuan X L) , 焦奎(Jiao K) , 谢江坤(Xie J K) , 张波(Zhang B) . 化学进展(Progress in Chemistry) ,2007 , 19 : 1007 —1015
[ 6 ] 　王振永(Wang Z Y) , 焦奎(Jiao K) , 孙伟(Sun W) , 李清军(Li Q J ) . 青岛科技大学学报(Journal of Qingdao University of Science and Technology(Natural Science Edition) ) , 2005 , 26 : 5 —8
[ 7 ] 　Kara P , Kagan K, Ozkan D , Meric B , Erdem A , Ozkan Z, Ozsoz M. Electrochem. Commun. , 2002 , 4 : 705 —709
[ 8 ] 　Lin X H , Wu P , Chen W, Zhang Y F , Xia X H. Talanta , 2007 ,72 : 468 —471
[ 9 ] 　Wang A H J , Ughetto G, Quigley G, et al . Biochemistry , 1987 ,26 : 1152 —1163
[10 ] 　Hashimoto K, Ito K, Ishimori Y, et al . Anal . Chem. , 1994 , 66 :3830 —3836
[11 ] 　Revenga-Parra M, García T, Lorenzo E , Pariente F. Biosens.Bioelectron. , 2007 , 22 : 2675 —2681
[12 ] 　Fang B , Jiao S , Li M, Qu Y, Jiang X. Biosens. Bioelectron. ,2008 , 23 : 1175 —1179
[13 ] 　Won B Y, Yoon H C , Park H G. Analyst , 2008 , 133 (1) : 100 —104
[14 ] 　Millan KM, Mikkelsen S R. Anal . Chem. , 1993 , 65 : 2317 —2323
[15 ] 　Garcia T, Revenga-Parra M, Abruna H D , Pariente F , Lorenzo E.Anal . Chem. , 2008 , 80 : 77 —84
[16 ] 　Korri-Youssoufi H , Bouchra M. Anal . Chim. Acta , 2002 , 469 :85 —92
[17 ] 　徐春(Xu C) , 蔡宏(Cai H) , 何品刚(He P G) , 方禹之(Fang Y Z) . 高等学校化学学报(Chem. J . Chin. Univ. ) , 2001 , 22 :1492 —1495
[18 ] 　Xiao Y, Qu X, Plaxco K W, Heeger A J . J . Am. Chem. Soc. ,2007 , 129 : 11896 —11897
[19 ] 　Lu Y, Li X, Zhang L , Yu P , Su L , Mao L. Anal . Chem. , 2008 ,80 : 1883 —1890
[20 ] 　Xiao Y, Lubin A A , Baker B R , et al . Proc. Natl . Acad. Sci .USA , 2006 , 103 : 16677 —16680
[21 ] 　徐春(Xu C) , 何品刚(He P G) , 方禹之(Fang Y Z) . 高等学校化学学报(Chem. J . Chin. Univ. ) , 2000 , 21 : 1187 —1190
[22 ] 　Kim K, Yang H , Park S H , Lee D , Kim S , Lim Y T, Kim Y T.Chem. Commun. , 2004 , 1466 —1467
[23 ] 　Willner I , Willner B. Pure Appl . Chem. , 2002 , 74 : 1773 —1783
[24 ] 　Ozsoz M, Erdem A , Kerman K, Ozkan D , Tugrul B , Topcuoglu N ,Ekren H , Taylan M. Anal . Chem. , 2003 , 75 : 2181 —2187
[25 ] 　Authier L , Grossiord C , Brossier P , Limoges B. Anal . Chem. ,2001 , 73 : 4450 —4456
[26 ] 　Kerman K, Morita Y, Takamura Y, Ozsoz M, Tamiya E. Anal .Chim. Acta , 2004 , 510 : 169 —174
[27 ] 　Cai H , Xu Y, Zhu N , He P , Fang Y. Analyst , 2002 , 127 : 803 —808
[28 ] 　Wang MJ , Sun C Y, Wang L Y, Ji X H , Bai YB , Li TJ , Li J H.J . Pharm. Biomed. Anal . , 2003 , 33 : 1117 —1125
[29 ] 　Karadeniz H , Erdem A , Caliskan A , Pereira C M, Pereira E M,Ribeiro J A. Electrochem. Commun. , 2007 , 9 : 2167 —2173
[30 ] 　Cai H , Wang Y, He P , Fang Y. Anal . Chim. Acta , 2002 , 469 :165 —172
[31 ] 　Lee TM H , Li L L , Hsing I M. Langmuir , 2003 , 19 : 4338 —4343
[32 ] 　Rochelet-Dequaire M, Limoges B , Brossier P. Analyst , 2006 , 131 :923 —929
[33 ] 　Zhang J , Song S P , Zhang L Y, Wang L H , Wu H P , Pan D , Fan C H. J . Am. Chem. Soc. , 2006 , 128 : 8575 —8580
[34 ] 　Li D , Yan Y, Wieckowska A , Willner I. Chem. Commun. , 2007 ,3544 —3546
[35 ] 　Moses S , Brewer S H , Kraemer S , Fuierer R R , Lowe L B , Agbasi C , Sauthier M, Franzen S. Sens. Actuators B , 2007 , 125 : 574 —580
[36 ] 　Cai H , Xu C , He P , Fang Y. J . Electroanal . Chem. , 2001 , 510 :78 —85
[37 ] 　Sun W, Zhong J , Zhang B , Jiao K. Anal . Bioanal . Chem. , 2007 ,389 : 2179 —2184
[38 ] 　Peng H , Soeller C , Cannell M B , Bowmaker G A , Cooney R P ,Travas-Sejdic J . Biosens. Bioelectron. , 2006 , 21 : 1727 —1736
[39 ] 　Hansen J A , Mukhopadhyay R , Hansen J O , Gothelf KV. J . Am.Chem. Soc. , 2006 , 128 : 3860 —3861
[40 ] 　Zhang D , Chen Y, Chen H Y, Xia X H. Anal . Bioanal . Chem. ,2004 , 379 : 1025 —1030
[41 ] 　Shrestha S , Yeung C M Y, Mills C E , Lewington J , Tsang S C.Angew. Chem. Int . Ed. , 2007 , 46 : 3855 —3859
[42 ] 　Erdem A , Sayar F , Karadeniz H , Guven G, Ozsoz M, Piskin E.Electroanalysis , 2007 , 19 : 798 —804
[43 ] 　Wang J , Xu D , Kawde A N , Polsky R. Anal . Chem. , 2001 , 73 :5576 —5581
[44 ] 　Wang J , Xu D , Polsky R. J . Am. Chem. Soc. , 2002 , 124 :4208 —4209
[45 ] 　Castaneda M T, Merkoci A , Pumera M, Alegret S. Biosens.Bioelectron. , 2007 , 22 : 1961 —1967
[46 ] 　Pumera M, Castaneda M T, Pividori M I , Eritja R , Merkoci A ,Alegret S. Langmuir , 2005 , 21 : 9625 —9629
[47 ] 　Liu H Y, Wang G F , Chen D L , Zhang W, Li I , Fang B. Sens.Actuators B. 2008 , 128 : 414 —421
[48 ] 　Wang J , Liu G, Rasul J M, Zhu Q. Electrochem. Commun. , 2003 ,5 : 1000 —1004
[49 ] 　Yang Y, Wang Z, Yang M, Li J , Zheng F , Shen G, Yu R. Anal .Chim. Acta , 2007 , 584 : 268 —274
[50 ] 　Zhu N N , Chang Z, He P G, Fang Y Z. Anal . Chim. Acta , 2005 ,545 : 21 —26
[51 ] 　Zhu N N , Cai H , He P G, Fang Y Z. Anal . Chim. Acta , 2003 ,481 : 181 —189
[52 ] 　Kawde A N , Wang J . Electroanalysis , 2004 , 16 : 1 —2
[53 ] 　Chang H , Yuan Y, Shi N , Guan Y. Anal . Chem. , 2007 , 79 :5111 —5115
[54 ] 　Wang Z, Yang Y, Leng K, Li J , Zheng F , Shen G, Yu R. Anal .Lett . , 2008 , 41 : 24 —35
[55 ] 　Pan J . Biochem. Eng. J . , 2007 , 35 : 183 —190
[56 ] 　Metfies K, Huljic S , Lange M, Medlin L K. Biosens. Bioelectron. ,2005 , 20 : 1349 —1357
[57 ]   Miranda-Castro R , de-los-Santos-Alvarez P , Lobo-Castanon M J ,Miranda-Ordieres A J , Tunon-Blanco P. Anal . Chem. , 2007 , 79 :4050 —4055
[58 ] 　Diaz-Gonzalez M, de la Escosura-Muniz A , Gonzalez-Garcia M B ,Costa-Garcia A. Biosens. Bioelectron. , 2008 , 23 : 1340 —1346
[59 ] 　Lin X H , Wan H Y, Zhang Y F , Chen J H. Talanta , 2008 , 74 :944 —950
[60 ] 　Berganza J , Olabarria G, Garcia R , Verdoy D , Rebollo A , Arana S.Biosens. Bioelectron. , 2007 , 22 : 2132 —2137
[1] Xiao Xiao, Changsheng Chen, Weiqiang Liu, Yeshun Zhang. Structure, Features and Biomedical Applications of Silk Sericin [J]. Progress in Chemistry, 2017, 29(5): 513-523.
[2] Li Shanjian, Feng Lajun. Preparation and Catalytic Application of Task-Specific Ionic Liquid Hybrid Solid-Phase Nano Materials [J]. Progress in Chemistry, 2014, 26(10): 1633-1644.