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Progress in Chemistry 2009, Vol. 21 Issue (0203): 340-349 Previous Articles   Next Articles

• Special issues •

Toxicological Research on Environmental Endocrine Disruptors

Shi Xiongjie; Liu Chunsheng; Yu Ke; Deng Jun; Yu Liqin; Zhou Bingsheng**   

  1. ( Institute of Hydrobiology , Chinese Academy of Sciences , Wuhan 430072 , China)
  • Received: Online: Published:
  • Contact: Zhou Bingsheng E-mail:bszhou@ihb.ac.cn
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Most evidence in terms of endocrine dsiruptors (EDs) mainly originates from studies on reproductive organs. However, in veterbrates, the ability to attain reproductive and development success relays on the intact organization of a complex endocrine system. Disturbances in the regulation of the key hormones and receptors functioning along this system may cause detrimental effects on reproduction and development. Here we reviewed recent studies of EDs on endocrine system. EDs may act on key hormones and receptors along with the hypothalamic–pituitary–gonald (HPG) axis and lead to reproductive failure. Thyroid disruption may be caused at different levels, for example, the synthesis, transport, binding and cellular uptake along with the hypothalamic–pituitary–thyroid (HPT) axis. Knowledge of model of action EDs is largely via receptors-mediated pathway and alternatively may affect on steroid hormone synthesis. Aquatic hypoxia can influence fish reproduction and thus it is also an endocrine disruptor. Molecular techniques, such as toxico-mics, transgenic fish will be employed as powerful tools for environmental EDs risk assessment, as well as in elucidating mechanisms of model action.

Contents
1 Hypothalamic-pituitary-gonadal/thyroid/adrenal axis
1.1 Hypothalamic-pituitary-gonadal axis （HPG axis）
1.2 Hypothalamic-pituitary-thyroid axis（HPT axis）
1.3 Hypothalamic-pituitary-adrenal axis （HPA axis）and in vitro model
2 The effects of aquatic hypoxia on endocrine system in fish
3 The application of omics in endocrine disruptor research
4 The application of transgenic fish in endocrine disruptor research
5 Perspectives of endocrine disruptor research

Key words: endocrine disruptors, endocrine system, risk assessment, toxicology

CLC Number: 

[ 1 ] 　伍吉云(Wu J Y) , 万　(Wang W) , 胡建英(Hu J Y) . 环境与健康杂志(Journal of Environment and Health) , 2005 , 22 : 494 —497
[ 2 ] 　张信连(Zhang L X) . 国外医学: 临床生物化学与检验学分册(Foreign Medical Sciences : Sect . Clin. Biochem. Lab. Med. ) ,2005 , 26 : 349 —351
[ 3 ] 　王有基(Wang Y J ) , 胡梦红(Hu M H) . 国外医学: 卫生学分册(Foreign Medical Sciences : Section Hygiene) , 2006 , 33 : 342 —347
[ 4 ] 　刘菲(Liu F) , 蒲力力( Pu L L) . 生殖医学杂志(Journal of Reproductive Medicine) , 2006 , 15 : 425 —428
[ 5 ] 　解美娜(Xie M N) , 张才乔(Zhang C Q) , 曾卫东( Zeng W D)等. 中国兽医学报(Chinese Journal of Veterinary) , 2004 , 24 :101 —103
[ 6 ] 　卫立(Wei L) , 张洪昌(Zhang H C) , 张爱茜(Zhang A Q) 等. 生态毒理学报(Asian Journal of Ecotoxicology) , 2007 , 2 : 25 —31
[ 7 ] 　吕潇(LüX) , 李慧冬(Li H D) , 杜红霞(Du H X) 等. 华中农业大学学报(Journal of Huazhong Agricultural University) , 2006 ,25 : 94 —100
[ 8 ] 　薛南冬(Xie N D) , 王洪波(Wang H B) , 徐晓白(Xu X B) . 科学通报(Chinese Science Bulletin) , 2005 , 22 : 2441 —2449
[ 9 ] 　张燕(Zhang Y) . 国外医学: 医学地理分册( Foregine Medical Sciences : Section of Medgeography) , 2005 , 26 : 32 —36
[10 ] 　孔元原(Kong Y Y) . 国外医学: 卫生学分册( Foregine Medical Sciences : Section Hygiene) , 2007 , 34 : 333 —338
[11 ] 　Achermann J C , Jameson J L. Mol . Endocrinol . , 1999 , 13 : 812 —818
[12 ] 　Zhang X, Hecker M, Park J W, et al . Aquat . Toxicol . , 2008 , 88 :173 —182
[13 ] 　Zhang X, Hecker M, Park J W, et al . Environ. Toxicol . Chem. ,2008 , 27 : 2504 —2511
[14 ] 　Zhang X, Hecker M, Jones P D , et al . Environ. Sci . Technol . ,2008 , 42 : 6762 —6769
[15 ] 　Nagahama Y. Steroid , 1997 , 62 : 190 —196
[16 ] 　Ankley G T, Miller D H , Jensen K M, et al . Aquat . Toxicol . ,2008 , 88 : 69 —74
[17 ] 　Cheshenko K, Pakdel F , Segner H , et al . Gen. Comp.Endocrinol . , 2008 , 155 : 31 —62
[18 ] 　Villeneuve D L , Larkin P , Knoebl I , et al . Environ. Sci .Technol . , 2007 , 41 : 321 —330
[19 ] 　Zoeller T R , Tan S W, Tyl R W. Cri . Rev. Toxicol . , 2007 , 37 :11 —53
[20 ] 　Pepels L M, Meek J , Bonga S E W, et al . J . Comp. Neurol . ,2002 , 453 : 247 —268
[21 ] 　Browna S B , Evans R E , Vandenbyllardt L , et al . Aquat . Toxicol . ,2004 , 67 : 75 —85
[22 ] 　LeRoy K D , Thomas P , Khan I A. Comp. Biochem. Physiol . ,2006 , 144C: 263 —271
[23 ] 　Kuiper R V , Vethaak A D , Cantón R F , et al . Chemosphere , 2008 ,73 : 195 —202
[24 ] 　Shi X, Du Y, Lam P K S , et al . Toxicol . Appl . Pharmacol . ,2008 , 230 : 23 —32
[25 ] 　Tsigos C , Chrousos G P. J . Psych. Res. , 2002 , 53 : 865 —871
[26 ] 　Pottinger T G, Moran T A. J . Fish Biol . , 2005 , 43 : 121 —130
[27 ] 　Hinson J P , Raven P W. Best Pract . Res. Clin. EndocrinolMetab. , 2006 , 20 : 111 —120
[28 ] 　Gracia T, Hilscherova K, Jones P D , et al . Ecotoxicol . Environ.Saf . , 2006 , 65 : 293 —305
[29 ] 　Bláha L , Hilscherová K, MazurováE , et al . Environ. Int . , 2006 ,32 : 749 —757
[30 ] 　Villeneuvea D L , Ankley G T, Makynen E A , et al . Ecotoxicol .Environ. Saf . , 2007 , 68 : 20 —32
[31 ] 　He Y, MurphyMB , Yu RM K, et al . Toxicol . Lett . , 2008 , 176 :230 —238
[32 ] 　Song R , He Y, Murphy M B , et al . Chemosphere , 2008 , 71 :1888 —1894
[33 ] 　Hecker M, Newste J L , Murphy M B , et al . Toxicol . Appl .Pharmacol . , 2006 , 217 : 114 —124
[34 ] 　Cantón R F , Scholten D E A , Marsh G, et al . Toxicol . Appl .Pharmacol . , 2008 , 227 : 68 —75
[35 ] 　Gracia T, Hilscherova K, Jones P D , et al . Toxicol . Appl .Pharmacol . , 2007 , 225 : 142 —153
[36 ] 　Furuta C , Noda S , Li C M, et al . Toxicol . Appl . Pharmacol . ,2008 , 229 : 109 —120
[37 ] 　Ding L , Murphy M B , He Y, et al . Environ. Toxicol . Chem. ,2007 , 26 : 764 —772
[38 ] 　Li L , Lin T. Toxicol . Appl . Pharmacol . , 2007 , 220 : 252 —261
[39 ] 　Gore A C. Front . Neuroendocrinol . , 2008 , 29 : 358 —374
[40 ] 　Wu R S S , Zhou B , Randall D J , et al . Environ. Sci . Technol . ,2003 , 37 : 1137 —1141
[41 ] 　Thomas P , Rahman MS , Khan I A , et al . Proc. Biol . Sci . , 2007 ,274 : 2693 —2671
[42 ] 　Shang E H H , Wu R S S. Environ. Sci . Technol . , 2004 , 38 :4763 —4767
[43 ] 　Shang E H H , Yu R M K, Wu R S S. Environ. Sci . Technol . ,2006 , 40 : 3118 —3122
[44 ] 　Moens L N , van der Ven K, van Remortel P , et al . Toxicol . Sci . ,2006 , 93 : 298 —310
[45 ] 　Wang D Y, McKague B , Liss S N , et al . Environ. Sci . Technol . ,2004 , 38 : 6396 —6406
[46 ] 　Naciff J M, Jump ML , Torontali SM, et al . Toxicol . Sci . , 2002 ,68 : 184 —199
[47 ] 　Benninghoff A D , Williams D E. Drug Metab. Rev. , 2006 , 38(suppl . 2) : 140 —141
[48 ] 　Shrader E A , Henry T R , Greeley M S , et al . Ecotoxicology , 2003 ,12 : 485 —488
[49 ] 　Walker C C , Salinas KA , Harris P S , et al . Toxicol . Sci . , 2006 ,95 : 174 —181
[50 ] 　Knoebl I , Blum J L , Hemmer M J , et al . J . Exp. Zool . , 2006 ,305A: 707 —719
[51 ] 　Robertson D G. Toxicol . Sci . , 2005 , 85 : 809 —822
[52 ] 　Samuelsson L M, Forlin L , Karlsson G, et al . Aquat . Toxicol . ,2006 , 78 : 341 —349
[53 ] 　Phillips R B , Reed KM. Chromosome Res. , 2000 , 8 : 27 —35
[54 ] 　Hill A J , Teraoka H , Heideman W, et al . Toxicol . Sci . , 2005 ,86 : 6 —19
[55 ] 　Ankley G T, Johnson R D. ILAR J . , 2004 , 45 : 469 —483
[56 ] 　Huuskonen H. Toxicol . Appl . Pharmacol . , 2005 , 207 : 495 —500
[57 ] 　Song H , Zhong T. [ 2008210201 ] http://news.xinhuanet.com/english/2007201/12/content-5597696.htm
[58 ] 　Halloran M C , Sato-Maeda M, Warren J T, et al . Development ,2000 , 127 : 1953 —1960
[59 ] 　Krone P H , Lele Z, Sass J B. Biochem. Cell Biol . , 1997 , 75 :487 —497
[60 ] 　Zeng Z, Shan T, Tong Y, et al . Environ. Sci . Technol . , 2005 ,39 : 9001 —9008
[61 ] 　Kurauchi K, Hirata T, Kinoshita M. Mar. Pollut . Bull . , 2008 , 57 :441 —444
[62 ] 　Scholz S , Kurauchi K, Kinoshita M, et al . Environ. Toxicol .Chem. , 2005 , 24 : 2553 —2561
[63 ] 　Ueno T, Yasumasu S , Hayashi S , et al . Mechanisms Dev. , 2004 ,121 : 803 —815
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