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Progress in Chemistry 2008, Vol. 20 Issue (09): 1324-1334 Previous Articles   Next Articles

• Review •

Antitumor Platinum(Ⅱ) Drugs

Zhu Xingyong1 Zhang Wenping2 You Qidong1* Zhang Cang2 Zuo Lijuan2   

  1. (1. China Pharmaceutical University, Nanjing 210009, China ; 2. Sanhome Pharmaceutical CO., L.T.D Nanjing 210038, China )
  • Received: Revised: Online: Published:
  • Contact: You Qidong
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Since cis-[PtⅡCl2(NH3)2] was used as an antitumor drug, the work to find novel antitumor agents among the platinum(Ⅱ) complexes has been developed extensively in the last decades. Cisplatin , carboplatin and oxaliplatin are so effective that they are widely used in clinical therapies. Nowadays, thousands of platinum complexes are designed and synthesized according to classical quantitative structure-activity relationship. In our paper, we reviewed the progress of antitumor platinum(Ⅱ) drug studies in recent five years. The antitumor mechanisms and activities of platinum(Ⅱ) complexes containing bioactive groups, sterically hindered platinum(Ⅱ) complexes, trans-platinum(Ⅱ) complexes, platinum(Ⅱ) complexes containing S or P atom and multiplatinum(Ⅱ) complexes are introduced and summaried.

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Antitumor Platinum(Ⅱ) Drugs