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Progress in Chemistry 2007, Vol. 19 Issue (012): 1928-1938 Previous Articles   Next Articles

• Invited Article •

Progress in Selenoenzyme Mimics

Liu Junqiu*; Luo Guimin; Shen Jiacong   

  1. （Key Laboratory for Supramolecular Structure and Materials, Jilin University, Changchun 130012, China）
  • Received: Revised: Online: Published:
  • Contact: Liu Junqiu
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Selenium, an essential trace element, has a long history of association with human health and diseases and exerts its important biological role as selenocysteine residue in selenoproteins. To exploration of the structural and functional importance of selenium in selenoproteins and for the potential applications in the development of selenium related medicine, significant efforts have been made in selenoprotein biomimetic chemistry. Because of the unique redox properties of selenium in mammalian selenoenzyme glutathione peroxidase (GPX), a number of organoselenium/tellurium compounds and selenoproteins were developed to mimic the native GPx. Herein, several strategies containing chemical and biological techniques or the combination of both for the redesign of selenoenzyme structure and function have been reviewed.
Key words: selenoenzyme, glutathione peroxidase（GPX）, enzyme mimic, selenium

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Abstract

Progress in Selenoenzyme Mimics