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Progress in Chemistry 2004, Vol. 16 Issue (03): 422- Previous Articles   Next Articles

• Review •

Progress on Pyrrole-Imidazole Polyamides Specifically Recognizing DNA

Lu Liping;Zhu Miaoli;Yang Pin**   

  1. (Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan 030006, China)
  • Received: Revised: Online: Published:
  • Contact: Yang Pin
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Pyrrole-imidazole polyamides containing W-methylpyrrole, JV-methylimidazole and N-methyl-3-hydroxy-pyrrole aromatic amino acids are synthetic ligands that have an affinity and specificity for DNA comparable to those of nat-urally occuring DNA binding proteins. In past two decades, a lot of polyamides including some bifunctional ligands that can specifically alkylate and cleavage DNA have been synthesized and simple paring rules and various binding models for the minor groove of the double helix developed that allow the design of ligands for predetermined DNA sequences. Poly-amides are also showed to permeate cells, potentially regulating transcription of specific genes.
Key words: pyrrole-imidazole polyamide, specific recognition, DNA

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