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Progress in Chemistry 2022, Vol. 34 Issue (9): 1957-1971 DOI: 10.7536/PC211129 Previous Articles   Next Articles

• Review •

Antitumor Activity and Application of Luminescent Iridium(Ⅲ) Complexes

Shunxin Gu, Qin Jiang(), Pengfei Shi   

  1. School of Environmental and Chemical Engineering, Jiangsu Ocean University,Lianyungang 222005, China
  • Received: Revised: Online: Published:
  • Contact: *e-mail: jiangqin@jou.edu.cn
  • Supported by:
    Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Lianyungang Petrel Project, Opening Foundation of Jiangsu Key Laboratory of Functional Control of Advanced Materials(jsklfctam201808); Jiangsu Provincial Graduate Scientific Research and Innovation Plan(KYCX20_2950)
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Iridium(Ⅲ) complexes have attracted much attention in the field of luminescent materials because of their high luminescence quantum yield, convenient wavelength regulation, long emission lifetime and good optical stability. Due to its strong cell permeability, Ir(Ⅲ) complex can target a variety of cell tissues and affect their structure and function, thus showing unique antitumor activity. Ir(Ⅲ) complexes have become a research hotspot in the direction of metal antitumor drugs, especially PDT photosensitizers. In this review, the structure-property relationship between the structure of Ir(Ⅲ) complexes and their luminescence and antitumor performances are summarized, the recent developments of Ir(Ⅲ) complexes in the fields of biological imaging, probes and sensors, antitumor therapy are highlighted. The scientific problems existing in the current research are discussed and future application of Ir(Ⅲ) complexes are also prospected.

Contents

1 Introduction

2 Structural modification of the Ir(Ⅲ) complexes

2.1 Mononuclear Ir(Ⅲ)complex

2.2 Multinuclear Ir(Ⅲ) complex

2.3 Macromolecular-Ir(Ⅲ) complex

3 Photophysical properties of Ir(Ⅲ) complexes

3.1 Single-photon emission of Ir(Ⅲ) complex

3.2 Two-photon emission of Ir(Ⅲ) complex

4 Biotargets for Ir(Ⅲ) complexes

4.1 Cell membrane

4.2 Cytoplasm

4.3 Cell organelle

5 Biological applications of Ir(Ⅲ) complexes

5.1 Bioimaging and biosensing

5.2 Antitumor diagnosis and therapy

6 Conclusion and outlook

Key words: iridium complexes, structure-activity regulation, luminescent materials, antitumor
Fig.1 Molecular structure diagram of mononuclear Ir(Ⅲ) complex[14⇓⇓⇓~18]
Fig.2 Molecular structure diagram of multinuclear Ir(Ⅲ) complex[19⇓⇓⇓⇓⇓~25]
Fig.3 Structure diagram of the Ir(Ⅲ)-macromolecular hybrid[26⇓⇓⇓⇓~31]
Fig.4 Molecular structure diagram of selected luminescent Ir(Ⅲ) complexes[32⇓⇓⇓⇓⇓⇓~39]
Fig.5 Molecular structure diagram of Ir(Ⅲ) complex with diverse intracellular biotarget[43⇓⇓⇓⇓⇓⇓⇓⇓~52]
Fig.6 Ir(Ⅲ) complexes applied for bioimage and biosensor[54⇓⇓⇓⇓⇓⇓⇓⇓~63]
Fig.7 Selected antitumot Ir(Ⅲ) complexes[64⇓⇓⇓⇓⇓⇓⇓⇓⇓⇓~75]
Fig.8 Selected antitumot Ir(Ⅲ) complexes[76⇓⇓⇓⇓⇓⇓⇓⇓~85]
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