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Progress in Chemistry 2018, Vol. 30 Issue (10): 1534-1547 DOI: 10.7536/PC180537 Previous Articles   Next Articles

• Review •

Design and Application of T1-T2 Dual-Modal MRI Contrast Agents

Guang Deng, Hong Yang, Zhiguo Zhou*, Shiping Yang*   

  1. College of Life and Environmental Sciences, Key laboratory of Resource Chemistry of MOE, Shanghai Normal University, Shanghai 200234, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China(No. 21571130, 21671135).
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Magnetic resonance imaging(MRI) has been used in the clinic widely as an early noninvasive diagnosis technique. According to the theory of MRI, three imaging modes exist, namely, T1-weighted imaging, T2-weighted imaging and diffusion weighted imaging. Accordingly, there are two types of exogenous MRI contrast agents, namely T1 contrast agent and T2 contrast agent, for improvement in contrast in MR images. Either T1 or T2 contrast agents has its own advantages and disadvantages, respectively. Recently, a kind of new contrast agents, T1-T2 dual-modal contrast agent, has been designed, which can be used on one machine with an accurate match of spatial and temporal imaging parameters. This article reviews the progress of design and chemical synthesis methods of T1-T2 dual-mode contrast agents, and also introduces their biomedical applications.
Contents
1 Introduction
2 The research about dual T1-T2 MRI contrast agents
2.1 Nanoparticles with a single metal
2.2 Nanoparticles with two types of MRI contrast agents
2.3 A type of metal doping
3 Conclusion
Key words: T1-T2 dual mode contrast agents, MRI, design, application

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