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Progress in Chemistry DOI: 10.7536/PC180625 Previous Articles   Next Articles

Special Issue: 酶化学

• Review •

Selenoprotein R: A Unique Methionine Sulfoxide Reductase

Tengrui Shi, Yujie Yang, Qiong Liu, Nan Li*   

  1. College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China
  • Received: Revised: Online: Published:
  • Supported by:
    The work was supported by the National Natural Science Foundation of China(No. 31700919) and the Shenzhen Science and Technology Innovation Committee(No. JCYJ20160520163119426).
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Selenoproteins represent a category of proteins that possess selenocysteine as the active center, by taking advantage of robust reducing ability of selenium, selenoproteins exert an important antioxidant function in various organisms. To date, there are 25 genes that encode selenoproteins found in human genome. Among them, selenoprotein R is the only methionine sulfoxide reductase that contains selenocysteine. It is located in the cytoplasm and nucleus, given the protein structure and strong nucleophilicity of selenium, selenoprotein R is competent to specifically reduce the oxidized sulfur in methionine-R-sulfoxide. Selenoprotein R could directly interact with many proteins, such as actin, transient receptor potential channel proteins, and β-amyloid protein. It may play crucial roles in the central nervous system and is closely related with the development of neurodegenerative diseases.
Contents
1 Introduction
2 The recognition of selenoprotein R and other Msrs
3 Phenotype induced by Msrs knockout
4 Involvement of selenoprotein R in neural degenerative disease
5 Conclusion and outlook
Key words: selenoprotein R, methionine sulfoxide reductase, central nervous system, neurodegenerative diseases

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