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Progress in Chemistry 2017, Vol. 29 Issue (6): 659-666 DOI: 10.7536/PC170352 Previous Articles   Next Articles

• Review •

Development and Application of Paper Spray Ionization Mass Spectrometry

Jingjing Liu1,2,3*, Xiaowei He1,2, Yan He1,2, Muqian Yu1,2, Le Jiang1,2, Bo Chen1,2*   

  1. 1. Key Laboratory of Phytochemical R & D of Hunan Province, Hunan Normal University, Changsha 410081, China;
    2. Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, Hunan Normal University, Changsha 410081, China;
    3. College of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
  • Received: Revised: Online: Published:
  • Contact: 10.7536/PC170352 E-mail:dr-chenpo@vip.sina.com;ljj52677@126.com
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (No.21575040,21405044,21275049) and the Natural Science Foundation of Hunan Province (No.2015JC1001).
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Paper spray ionization mass spectrometry (PSI-MS) is a new technology of mass spectrometry. This method uses low-cost paper as the carrier, and solid or liquid sample is added to a triangular paper substrate. Through the application of high voltage, the target molecules in the high voltage electric field are driven to reach the paper tip, then a charged spray for PSI-MS is generated. This technology combines the characteristics of ambient mass spectrometry (AMS) and electrospray ionization (ESI) technology, and can analyze sample or substance attached to the sample surface in an open atmospheric environment. It has many advantages such as low cost, high throughput, simple, real-time and fast, and it can also simplify the work processes, improving the usability of mass spectrometry equipment. Herein, a general overview of PSI-MS is given in this paper, including the principle, influencing factors (paper substrate, spray solution, elution mode, and internal standard), the improvement and development of the technology, and corresponding applications in various fields (i.e. biological samples, phytochemistry, variety identification, food safety, and environmental analysis) in recent years. Characteristics and advantages of this technology are introduced in details. A number of studies have proved that PSI-MS is a widely used analytical technique with great prospects. Finally, the shortcomings of PSI-MS in terms of accurate quantification, carrier selection and field analysis are discussed, and some ideas for its improvement are put forward.

Contents
1 Introduction
2 Principle of PSI-MS
3 Influencing Factors
3.1 Paper substrate
3.2 Spray solution
3.3 Elution mode
3.4 Other factors
4 Modification of PSI-MS
4.1 Paper modification
4.2 Improvement of solvent supply
4.3 Improvement of sampling
4.4 PSI-MS combined with other technologies
4.5 Derivation of PSI-MS
5 Application of PSI-MS
5.1 Analysis of biological samples
5.2 Analysis of phytochemistry
5.3 Variety identification
5.4 Food safety
5.5 Environmental analysis
6 Conclusion and outlook

Key words: ambient mass spectrometry, electrospray ionization, direct spray ionization, paper spray ionization mass spectrometry

CLC Number: 

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