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Progress in Chemistry 2015, Vol. 27 Issue (2/3): 212-219 DOI: 10.7536/PC140921 Previous Articles   Next Articles

• Review •

Application of Polydopamine in Surface Modification of Biomaterials

Liu Zongguang, Qu Shuxin*, Weng Jie   

  1. Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
  • Received: Revised: Online: Published:
  • Supported by:

    The work was supported by the National Basic Research Program of China (973 Program)(No.2012CB933602), the National Natural Science Foundation of China (No.51372210) and the Research Fund for the Doctoral Program of Higher Education of China (No. 20130184110023).

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Inspired by the strong adhesive proteins secreted by mussels for attachment onto a wide range of substrates in wet condition, some reports indicated that polydopamine (PDA) possesses the similar structure and strong adhesion to those of adhesive proteins. PDA film can be formed on the surface of substrate in alkaline solution expeditiously, which results in the improvement of the hydrophily and the chemical versatility of substrate due to the hydrophilic hydroxyl and amino groups of PDA. The PDA layer can be used as an intermediate to anchor functional molecules on the surface through chemical bonds (by Michael addition or Schiff base reaction) or other physical bonds (hydrogen bond or van der Waals' force). PDA surface modification strategy is extremely useful because the process is simple and solvent-free. Moreover, due to the improvement of cell adhesion and biocompatibility, PDA has been widely used in surface modification of biomaterials. In this review, adhesive mechanism and application of PDA in surface modification of biomaterials have been summarized. In addition, the problems existed and the promising prospects of the application of PDA in biomaterials are pointed out.This review also provides useful information for the potential application of PDA in biomaterials and tissue engineering.

Contents
1 Introduction
2 Formation process and mechanism of PDA
3 Application of PDA
3.1 Increasing the hydrophilicity of biomaterials with PDA
3.2 Immobilizing drugs or growth factors with PDA
3.3 Immobilizing silver nanoparticles with PDA
3.4 Immobilizing proteins with PDA
3.5 Increasing the biocompatibility of substrates with PDA
3.6 Inducing mineralization on the surface of substrates with PDA
3.7 Application of PDA in other aspects
4 Conclusion and outlook

Key words: mussel-inspired, polydopamine, surface modification, biomaterials

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