[1] Turnbaugh P J, Ley R E, Hamady M, Fraser-Liggett C M, Knight R, Gordon J I. Nature, 2007, 449: 804—810
[2] Whitman W B, Coleman D C, Wiebe W J. Proc. Natl. Acad. Sci. U.S.A., 1998, 95: 6578—6583
[3] Qin J J, Li R Q, Raes J, Arumugam M, Burgdorf K S, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, Mende D R, Li J H, Xu J M, Li S C, Li D F, Cao J J, Wang B, Liang H Q, Zheng H S, Xie Y L, Tap J, Lepage P, Bertalan M, Batto J M, Hansen T, Le Paslier D, Linneberg A, Nielsen H B, Pelletier E, Renault P, Sicheritz-Ponten T, Turner K, Zhu H M, Yu C, Li S T, Jian M, Zhou Y, Li Y R, Zhang X Q, Qin N, Yang H M, Wang J, Brunak S, Doré J, Guarner F, Kristiansen K, Pedersen O, Parkhill J, Weissenbach J, Bork P, Ehrlich S D, Wang J. Nature, 2010, 464: 59—65
[4] Riesenfeld C S, Schloss P D, Handelsman J. Annu. Rev. Genet., 2004, 38: 525—552
[5] Streitand W R, Schmitz R A. Curr. Opin. Microbiol., 2004, 7: 492—498
[6] Eloe-Fadrosh E A, Rasko D A. Annu. Rev. Med., 2013, 64: 145—163
[7] Holmes E, Li J V, Marchesi J R, Nicholson J K. Cell Metab., 2012, 16: 559—564
[8] De Vosand W M, de Vos E A. Nutr. Rev., 2012, 70(Suppl 1): S45—S56
[9] Vipperla K, O'Keefe S J. Nutr. Clin. Pract., 2012, 27: 624—635
[10] Howitt M R, Garrett W S. Nat. Med., 2012, 18: 1188—1189
[11] Turnbaugh P J, Ley R V, Mahowald M A, Magrini V, Mardis E R, Gordon J I. Nature, 2006, 444: 1027—1031
[12] Guarner F, Malagelada J R. Lancet, 2003, 361: 512—519
[13] Maynard C L, Elson C O, Hatton R D, Weaver C T. Nature, 2012, 489: 231—241
[14] Damman C J, Miller S I, Surawicz C M, Zisman T L. Am. J. Gastroenterol., 2012, 107: 1452—1459
[15] Kallus S J, Brandt L J. J. Clin. Gastroenterol., 2012, 46: 16—24
[16] Clemente J C, Ursell L K, Parfrey L W, Knight R. Cell, 2012, 148: 1258—1270
[17] Akaza H. Cancer Sci., 2012, 103: 969—975
[18] Compare D, Nardone G. Dig. Dis., 2011, 29: 554—561
[19] Ridlon J M, Kang D J, Hylemon P B. J. Lipid Res., 2006, 47: 241—259
[20] Niu T, Smith D L, Yang Z, Gao S, Yin T, Jiang Z H, You M, Gibbs R A, Petrosino J F, Hu M. Pharm. Res., 2013, 30: 836—846
[21] Haiser H J, Turnbaugh P J. Science, 2012, 336: 1253—1255
[22] Guengerich F P. Chem. Res. Toxicol., 2008, 21: 70—83
[23] Dong D, Ako R, Wu B J. Expert Opin. Drug Metab. Toxicol., 2012, 8: 635—646
[24] Dong D, Ako R, Hu M, Wu B J. Xenobiotica, 2012, 42: 808—820
[25] Oakley A. Drug Metab. Rev., 2011, 43: 138—151
[26] Yang Z, Zhu W, Gao S, Yin T, Jiang W, Hu M. Drug Metab. Dispos., 40: 1883—1893
[27] Liu Y, Hu M. Drug Metab. Dispos., 2002, 30: 370—377
[28] Daly A K. Adv. Pharmacol., 2012, 63: 137—167
[29] Kiyotani K, Mushiroda T, Nakamura Y, Zembutsu H. Drug Metab. Pharmacokinet., 2012, 27: 122—131
[30] Nagar S, Blanchard R L. Drug Metab. Rev., 2006, 38: 393—409
[31] Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende D R, Fernandes G B, Tap J, Bruls T, Batto J M, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, Hansen T, Hattori M, Hayashi T, Kleerebezem M, Kurokawa K, Leclerc M, Levenez F, Manichanh C, Nielsen H B, Nielsen T, Pons N, Poulain J, Qin J, Sicheritz-Ponten T, Tims S, Torrents D, Ugarte E, Zoetendal E G, Wang J, Guarner F, Pedersen O, de Vos W M, Brunak S, Doré J, Antolin M, Artiguenave F, Blottiere H M, Almeida M, Brechot C, Cara C, Chervaux C, Cultrone A, Delorme C, Denariaz G, Dervyn R, Foerstner K U, Friss C, van de Guchte M, Guedon E, Haimet F, Huber W, van Hylckama-Vlieg J, Jamet A, Juste C, Kaci G, Knol J, Lakhdari O, Layec S, Le Roux K, Maguin E, Merieux A, Melo Minardi R, M'Rini C, Muller J, Oozeer R, Parkhill J, Renault P, Rescigno M, Sanchez N, Sunagawa S, Torrejon A, Turner K, Vandemeulebrouck G, Varela E, Winogradsky Y, Zeller G, Weissenbach J, Ehrlich S D, Bork P. Nature, 2011, 473: 174—180
[32] Wu G D, Chen J, Hoffmann C, Bittinger K, Chen Y Y, Keilbaugh S A, Bewtra M, Knights D, Walters W A, Knight R, Sinha R, Gilroy E, Gupta K, Baldassano R, Nessel L, Li H Z, Bushman F D, Lewis J D. Science, 2011, 334: 105—108
[33] Eckburg P B, Bik E M, Bernstein C N, Purdom E, Dethlefsen L, Sargent M, Gill S R, Nelson K E, Relman D A. Science, 2005, 308: 1635—1638
[34] Turnbaugh P J, Quince C, Faith J J, McHardy A C, Yatsunenko T, Niazi F, Affourtit J, Egholm M, Henrissat B, Knight R, Gordon J I. Proc. Natl. Acad. Sci. U.S.A., 2010, 107: 7503—7508
[35] Huse S M, Ye Y Z, Zhou Y J, Fodor A A. PLoS One, 2012, 7: e34242
[36] Costello E K, Lauber C L, Hamady M, Fierer N, Gordon J I, Knight R. Science, 2009, 326: 1694—1697
[37] Whittaker R H. Taxon, 1972, 21: 213—251
[38] Bohannan B J M, Hughes J. Curr. Opin. Microbiol., 2003, 6: 282—287
[39] Elmqvist T, Folke C, Nyström M, Peterson G, Bengtsson J,Walker B, Norberg J. Front Ecol. Environ., 2003, 1: 488—494
[40] Wang Y W, Hoenig J D, Malin K J, Qamar S, Petrof E O, Sun J, Antonopoulos D A, Chang E B, Claud E C. ISME J., 2009, 3: 944—954
[41] Klepac-Ceraj V, Lemon K P, Martin T R, Allgaier M, Kembel S W, Knapp A A, Lory S, Brodie E L, Lynch S V, Bohannan B K M, Green J L, Maurer B A, Kolter R. Environ. Microbiol., 2010, 12: 1293—1303
[42] Govan J R, Deretic V. Microbiol. Rev., 1996, 60: 539—574
[43] Johnston B C, Goldenberg J Z, Vandvik P O, Sun X, Guyatt G H. Cochrane Database Syst. Rev., 2011, 9: CD004827
[44] Johnston B C, Supina A L, Ospina M, Vohra S. Cochrane Database Syst. Rev., 2007, 18: CD004827
[45] Nicholson J K, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, Pettersson S. Science, 2012, 336: 1262—1267
[46] Tremaroli V, Bäckhed F. Nature, 2012, 489: 242—249
[47] Samuel B S, Shaito A, Motoike T, Rey F E, Backhed F, Manchester J K, Hammer R E, Williams S C, Crowley J, Yanagisawa M, Gordon J I. Proc. Natl. Acad. Sci. USA, 2008, 105: 16767—16772
[48] Samuel B S, Gordon J I. Proc. Natl. Acad. Sci. U.S.A., 2006, 103: 10011—10016
[49] Wong J M W, de Souza R, Kendall C W C, Emam A, Jenkins D J A. J. Clin. Gastroenterol., 2006, 40: 235—243
[50] Zimmerman M A, Singh N, Martin P M, Thangaraju M, Ganapathy V, Waller J L, Shi H D, Robertson K D, Munn D H, Liu K B. Am. J. Physiol. Gastroint. Liver Physiol., 2012, 302: G1405—G1415
[51] Hylemon P B, Zhou H P, Pandak W M, Ren S L, Gil G, Dent P. J. Lipid Res., 2009, 50: 1509—1520
[52] Wang Z N, Klipfell E, Bennett B J, Koeth R, Levison B S, Dugar B, Feldstein A E, Britt E B, Fu X M, Chung Y M, Wu Y P, Schauer P, Smith J D, Allayee H, Tang W H W, DiDonato J A, Lusis A J, Hazen S L. Nature, 2011, 472: 57—63
[53] Mouzaki M, Allard J P. J. Clin. Gastroenterol., 2012, 46: 457—467
[54] Abu-Shanab A, Quigley E M M. Nat. Rev. Gastroenterol. Hepatol., 2010, 7: 691—701
[55] Craciun S, Balskus E P. Proc. Natl. Acad. Sci. U.S.A., 2012, 109: 21307—21312
[56] Strober W, Fuss I J, Blumberg R S. Annu. Rev. Immunol., 2002, 20: 495—549
[57] Maslowski K M, Vieira A T, Ng A, Kranich J, Sierro F, Yu D, Schilter H C, Rolph M S, Mackay F, Artis D, Xavier R J, Teixeira M M, Mackay C R. Nature, 2009, 461: 1282—1286
[58] Frank D N, St Amand A L, Feldman R A, Boedeker E C, Harpaz N, Pace N R. Proc. Natl. Acad. Sci. USA, 2007, 104: 13780—13785
[59] Ley R E, Backhed F, Turnbaugh P, Lozupone C A, Knight R D, Gordon J I. Proc. Natl. Acad. Sci. USA, 2005, 102: 11070—11075
[60] Ley R E, Peterson D A, Gordon J I. Cell, 2006, 124: 837—848
[61] Burcelin R, Crivelli V, Dacosta A, Roy-Tirelli A, Thorens B. Am. J. Physiol. Endocrinol. Metab., 2002, 282: E834—E842
[62] Bäckhed F, Manchester J K, Semenkovich C F, Gordon J I. Proc. Natl. Acad. Sci. USA, 2007, 104: 979—984
[63] Mandard S, Zandbergen F, van Straten E, Wahli W, Kuipers F, Müller M, Kersten S. J. Biol. Chem., 2006, 281: 934—944
[64] Kamangar F, Dores G M, Anderson W F. J. Clin. Oncol., 2006, 24: 2137—2150
[65] Sobhani I, Tap J, Roudot-Thoraval F, Roperch J P, Letulle S, Langella P, Corthier G, Van Nhieu J T, Furet J P. PLoS One, 2011, 6: e16393.
[66] Sears C L, Pardoll D M. J. Infect. Dis., 2011, 203: 306—311
[67] Boleij A, Tjalsma H. Biol. Rev., 2012, 87: 701—730
[68] Lemon K P, Armitage G C, Relman D A, Fischbach M A. Sci. Transl. Med., 2012, 4: 137rv5
[69] Wallace B D, Wang H W, Lane K T, Scott J E, Orans J, Koo J S, Venkatesh M, Jobin C, Yeh L A, Mani S, Redinbo M R. Science, 2010, 330: 831—835
[70] Davis C D, Milner J A. J. Nutr. Biochem., 2009, 20: 743—752
[71] Swidsinski A, Loening-Baucke V, Vaneechoutte M, Doerffel Y. Inflamm. Bowel Dis., 2008, 14: 147—161
[72] Jemal A, Siegel R, Xu J, Ward E. CA Cancer J. Clin., 2010, 60: 277—300
[73] Clark J, You M. Mol. Nutr. Food Res., 2006, 50: 144—151
[74] Hecht S S. Drug Metab. Rev., 2000, 32: 395—411
[75] Tan X L, Spivack S D. Lung Cancer, 2009, 65: 129—137
[76] Yan Y, Wang Y, Tan Q, Hara Y, Yun T K, Lubet R A, You M. Neoplasia, 2006, 8: 52—58
[77] Yun T K. Ann. N. Y. Acad. Sci., 1999, 889: 157—192
[78] Cimino S, Sortino G, Favilla V, Castelli T, Madonia M, Sansalone S, Russo G I, Morgia G. Oxid. Med. Cell. Longev., 2012, art. no. 632959
[79] Stagos D, Amoutzias G D, Matakos A, Spyrou A, Tsatsakis A M, Kouretas D. Food Chem. Toxicol., 50: 2155—2170
[80] Baumeister P, Reiter M, Harreus U. Oxid. Med. Cell Longev., 2012, art. no. 902716
[81] Hecht S S, Kassie F, Hatsukami D K. Nat. Rev. Cancer, 2009, 9: 476—488
[82] Gao S, Basu S, Yang Z, Deb A, Hu M. Curr. Drug Targets, 2012, 13: 1885—1899
[83] Chow H H, Hakim I A. Pharmacol. Res., 2011, 64: 105—112
[84] Yang Z, Wang J R, Niu T, Gao S, Yin T J, You M, Jiang Z H, Hu M. Drug Metab. Dispos., 2012, 40: 1538—1544
[85] Hou J G, Xue J J, Sun M Q, Wang C Y, Liu L, Zhang D L, Lee M R, Gu L J, Wang C L, Wang Y B, Zheng Y, Li W, Sung C K. J. Appl. Microbiol., 2012, 113: 807—814
[86] Kim E M, Kim J, Seo J H, Park J S, Kim D H, Kim B G. Appl. Environ. Microbiol., 2012, 78: 242—249
[87] Chi H, Ji G E. Biotechnol. Lett., 2005, 27: 765—771
[88] Chen G T, Yang M, Song Y, Lu Z Q, Zhang J Q, Huang H L, Guan S H, Wu L J, Guo D A. Biomed. Chromatogr., 2008, 22: 779—785
[89] Bae E A, Han M J, Choo M K, Park S Y, Kim D H. Biol. Pharm. Bull., 2002, 25: 58—63
[90] Yang C S, Sang S, Lambert J D, Lee M J. Mol. Nutr. Food Res., 2008, 52(Suppl 1): S139—S151
[91] Yang C S, Wang X, Lu G, Picinich S C. Nat. Rev. Cancer, 2009, 9: 429—439
[92] Mimoto J, Kiura K, Matsuo K, Yoshino T, Takata I, Ueoka H, Kataoka M, Harada M. Carcinogenesis, 2000, 21: 915—919
[93] Liao J, Yang G Y, Park E S, Meng X F, Sun Y H, Jia D X, Seril D N, Yang C S. Nutr. Cancer, 2004, 48: 44—53
[94] Ju J, Lu G, Lambert J D, Yang C S. Semin. Cancer Biol., 2007, 17: 395—402
[95] Bettuzzi S, Brausi M, Rizzi F, Castagnetti G, Peracchia G, Corti A. Cancer Res., 2006, 66: 1234—1240
[96] Atkinson C, Frankenfeld C L, Lampe J W. Exp. Biol. Med., 2005, 230: 155—170
[97] Decroos K, Vanhemmens S, Cattoir S, Boon N, Verstraete W. Arch. Microbiol., 2005, 183: 45—55
[98] Muthyala R S, Ju Y H, Sheng S B, Williams L D, Doerge D R, Katzenellenbogen B S, Helferich W G, Katzenellenbogen J A. Bioorg. Med. Chem., 2004, 12: 1559—1567
[99] Miyanaga N, Akaza H, Hinotsu S, Fujioka T, Naito S, Namiki M, Takahashi S, Hirao Y, Horie S, Tsukamoto T, Mori M, Tsuji H. Cancer Sci., 2012, 103: 125—130
[100] Luciano F B, Holley R A. Int. J. Food Microbiol., 2009, 131: 240—245
[101] Saavedra M J, Borges A, Dias C, Aires A, Bennett R N, Rosa E S, Simöes M. Med. Chem., 2010, 6: 174—183
[102] Kim Y, Lee D, Kim D, Cho J, Yang J, Chung M, Kim K, Ha N. Arch. Pharm. Res., 2008, 31: 468—473
[103] Azcárate-Peril M A, Sikes M, Bruno-Bárcena J M. Am. J. Physiol. Gastrointest. Liver Physiol., 2011, 301: G401—G424
[104] Rafter J, Bennett M, Caderni G, Clune Y, Hughes R, Karlsson P C, Klinder A, O'Riordan M, O'Sullivan G C, Pool-Zobel B, Rechkemmer G, Roller M, Rowland I, Salvadori M, Thijs H, Van Loo J, Watzl B, Collins J K. Am. J. Clin. Nutr., 2007, 85: 488—496
[105] Limburg P J, Mahoney M R, Ziegler K L, Sontag S J, Schoen R E, Benya R, Lawson M J, Weinberg D S, Stoffel E, Chiorean M, Heigh R, Levine J, Della'Zanna G, Rodriguez L, Richmond E, Gostout C, Mandrekar S J, Smyrk T C. Cancer Prev. Res. (Phila), 4: 259—269
[106] Limburg P J, Mandrekar S J, Aubry M C, Ziegler K L, Zhang J, Yi J E, Henry M, Tazelaar H D, Lam S, McWilliams A, Midthun D E, Edell E S, Rickman O B, Mazzone P, Tockman M, Beamis J F, Lamb C, Simoff M, Loprinzi C, Szabo E, Jett J. Lung Cancer, 2013, 79: 254—261