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Progress in Chemistry 2013, Vol. 25 Issue (09): 1526-1543 DOI: 10.7536/PC130717 Previous Articles   Next Articles

Perspective on Nrf2, Epigenomics and Cancer Stem Cells in Cancer Chemoprevention Using Dietary Phytochemicals and Traditional Chinese Medicines

Zheng-Yuan Su1, Limin Shu1, Jong Hun Lee1,2, Franciso Fuentes1, Hu Wang1, Tien-Yuan Wu3, Siwang Yu1,Ah-Ng Tony Kong1*   

  1. 1. Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest-Mario School of Pharmacy, Rutgers, the State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA;
    2. Departamento de Agricultura del Desierto y Biotecnología, Universidad Arturo Prat, Casilla 121, Iquique, Chile;
    3. Departament of Chemical Biology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100190, China
  • Received: Online: Published:
  • Contact: Ah-Ng Tony Kong E-mail:KongT@pharmacy.rutgers.edu
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Cancer is one of the leading causes of death worldwide. The innovation of modern diagnostics and chemotherapeutics has improved cancer patients' treatment and care, but advanced stages of cancer remain extremely challenging to treat. Therefore, new and creative approaches are needed to prevent and treat cancer. Herbal medicines have been used for many centuries to prevent diseases such as cancer. Funding agencies, such as the National Cancer Institute in the United States, have recently emphasized support for cancer chemoprevention research using natural phytochemicals and non-toxic drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) to prevent or delay the onset of cancer. This perspective distills the latest in cancer chemoprevention research using bioactive components from fruits, vegetables, green tea and Traditional Chinese Medicines (TCM), focusing on Nrf2, epigenomic and cancer stem cell effects.

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