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Thiol-Ene Click Chemistry

Xu Yuanhong1, Xiong Xingquan1*, Cai Lei1, Tang Zhongke1, Ye Zhangji2,3   

  1. 1. The Key Laboratory for Functional Materials of Fujian Higher Education, College of Materials Science & Engineering, Huaqiao University, Xiamen 361021, China;
    2. Xiamen Branch of Luoyang Ship Material Research Institute, Xiamen 361002, China;
    3. State Key Laboratory for Marine Corrosion and Protection, Xiamen 361002, China
  • Received: Revised: Online: Published:
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“Click chemistry”, introduced by Sharpless in 2001, becomes a new synthetic method used in areas such as drugs, polymers and materials rapidly because of its high efficiency, high selectivity and reliable characteristics. With the further research on click chemistry, the types of it are increasing continuously and the scope of application is also expanding. Radical-mediated or nucleophile-initiated thiol-ene reaction is a novel kind of click reactions, which shows the characteristics of click chemistry. Starting from the concept, characteristic and types of click chemistry, the mechanism and the wide applications of thiol-ene reaction in preparation of functional polymers and topologic macromolecules, polymeric materials surface modification and biomaterials are emphasized. Furthermore, the latest research based on thiol-ene chemistry is summarized. The prospects of thiol-ene reaction are also discussed. Contents
1 Introduction
2 Thiol-ene click reaction and mechanism
3 Applications of thiol-ene click chemistry
3.1 Synthesis of functional polymers
3.2 Synthesis of topologies polymers
3.3 Surface modification
3.4 Biological fields
3.5 Other fields
4 Conclusions and outlook

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Thiol-Ene Click Chemistry