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Progress in Chemistry 2011, Vol. 23 Issue (5): 930-940 Previous Articles   Next Articles

• Review •

Amphiphilic Block Copolymer Micelles for Medical Materials

He Wen1, Ding Yuanju1, Lu Zaijun1, Yang Qifeng2   

  1. 1. Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China;
    2. Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan 250012, China
  • Received: Revised: Online: Published:
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Amphiphilic block copolymers can self assemble into micelles containing the outer shell of hydrophilic blocks and inner core of hydrophobic blocks in aqueous solution. These micelles can be used for drug carriers and have attracted much attention. In this article, we review the research progress in amphiphilic block copolymer micelles for medical materials, including species of medical amphiphilic block copolymers, micellization, and carriers of diagnostics, drug release and targeting. Amphiphilic block copolymer micelles as MRI contrast agent carriers are beneficial to tumor diagnosis. These micelles as drug carriers can enhance the solubility of hydrophobic anticancer drugs and extend drug circulation time in vivo. In addition, amphiphilic block copolymer micelles are capable of achieving the target function through either attachment of targeting ligands to the micelle surface or introduction of external fields. Therefore, the amphiphilic block copolymer micelles have broad development prospects in the field of medical materials.

Key words: amphiphilic block copolymers, micelles, diagnostics, drug release, targeting

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