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• Review •

Transition Metal-Catalyzed Trifluoromethylation Reaction of Aromatic Compounds

Qi Zisong, Dong Yali, Li Yaming, Duan Chunying   

  1. State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
  • Received: Revised: Online: Published:
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Transition metal-catalyzed trifluoromethylation of aromatic compounds has been developed rapidly during the last decade. The substrate scope is expanding, new methods and novel trifluoromethyl reagents are continuing to emerge. Recent advances in transition metal-catalyzed trifluoromethylation of aromatic compounds are summarized in this paper. The reactions involve trifluoromethylation of aryl halides, arylboronic acids and C—H trifluoromethylation of arenes. In addition, the mechanisms of transition metal-catalyzed trifluoromethylation are discussed in details. Contents
1 Trifluoromethylation of aryl halides
1.1 Copper-mediated (catalyzed) trifluoromethyla-tion
1.2 Palladium and other metal-mediated (catalyzed) trifluoromethylation
2 Trifluoromethylation of arylboronic acids
2.1 CF3 SiR3 as trifluoromethyl reagents
2.2 Electrophilic trifluoromethyl reagents
2.3 Other trifluoromethyl reagents
3 C—H trifluoromethylation of aromatics
3.1 Direct C—H trifluoromethylation of aromatics
3.2 Indirect C—H trifluoromethylation of aromatics
4 Conclusion and outlook
Key words: transition metal-catalyzed, aromatic compounds, trifluoromethylation

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