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• Review •

Ring-Opening Polymerization of ε-Caprolactone Catalyzed by Organocatalyst

Xu Rong, Chen Chunxia   

  1. College of Science, Northeast Forestry University, Harbin 150040, China
  • Received: Revised: Online: Published:
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Poly(ε-caprolactone) (PCL) is an important class of biocompatible materials, which makes them interesting materials for a range of biomedical and commodity applications, including controlled drug release, tissue engineering, medical implants or environmentally friendly packaging materials. PCL can be prepared through the ring-opening polymerization of ε-caprolactone catalyzed by organic molecules. Compared to traditional metal-catalyzed ROPs, organocatalysis processes can be performed under milder reaction conditions with controlled molar masses and narrow dispersities, furthermore the metal contaminants of the polymer products can be avoided to be removed prior to application as biomedical and pharmaceutical materials. Herein the progress of organocatalysts in the ring-opening polymerization of ε-caprolactone is reviewed according to different means of the activation of the catalysts. The advantages and disadvantages of various catalytic systems are summarized, and development trends and application prospects of organocatalysis for polymerization of ε-caprolactone are also discussed. Contents 1 Introduction
2 Organocatalysts based on electrophilic monomer activation
3 Lewis bases and organocatalysts based on nucleophilic monomer activation
3.1 Organocatalysis by nucleophilic monomer activation
3.2 Organocatalysis by initiator/chain-end activation
4 Synergistic bifunctional organocatalysts and initiator/chain-end activation
5 Conclusion
Key words: organocatalysis, ring-opening polymerization(ROP), &epsilon, -caprolactone

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