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• Review •

Recent Progress of Acridine Derivatives with Antitumor Activity

Lang Xuliang1,2, Luan Xudong1,2, Gao Chunmei2,3, Jiang Yuyang1,2,3,4   

  1. 1. Department of Chemistry, Tsinghua University, Beijing 100084, China;
    2. The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, Shenzhen 518055, China;
    3. Shenzhen Anti-Tumor Drug Development Engineering Laboratory, the Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China;
    4. School of Medicine, Tsinghua University, Beijing 100084, China
  • Received: Revised: Online: Published:
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Acridines are a series of heterocyclic compounds, which have been received intense interest and used as anti-inflammatory, antibacterial and antitumour agents. This paper reviews some recent progresses in the research of the antitumor activity of acridine derivatives, including as the inhibition of telomerase, topoisomerases Ⅰ and Ⅱ, tubulin, ABCG2/P-gP, protein kinases, etc. The prospects and potential applications of such acridine compounds are outlooked. Contents 1 Introduction
2 Antitumor activity of acridine derivatives
2.1 Telomerase inhibition
2.2 Topoisomerase inhibition
2.3 Tubulin inhibition
2.4 Protein-kinase inhibition
2.5 P-gP and ABCG2 inhibition
3 Conclusion and Prospects
Key words: acridine, antitumor, drug targets

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