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Progress in Chemistry 2012, Vol. 24 Issue (05): 844-851 Previous Articles   Next Articles

• Review •

Molecularly Imprinted Polymers as Antibody Alternatives in Sorbent Immunoassays

Lv Chunhui1,2, Wang Shuo2, Fang Guozhen2, Tang Yiwei2, Wang Suilou1*   

  1. 1. School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China;
    2. Key Laboratory of Food Nutrition and Safety of Ministry of Education, Tianjin University of Science & Technology, Tianjin 300457, China
  • Received: Revised: Online: Published:
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Molecularly imprinted polymer(MIP), a material which owns artificially-created binding sites coupled with several distinct advantages such as high chemical, mechanical and thermal stability, robust, easy preparation, low cost and reusable. MIP as mimic in pseudo-immunoassays have attracted considerable attention over the last few years. The advances in molecularly imprinted sorbent immunoassays(MIAs) are reviewed from radioligand immunoassays to non-radioligand immunoassays, and emphasize on the promotion which homogeneous immunoassay systems and new synthesis methods bring. It is shown that the perceived disadvantages of MIP can be ignored in MIAs. The existing problems and prospects of MIAs are also described.

Contents
1 Introduction
2 Molecularly imprinted sorbent immunoassays(MIAs)
2.1 Heterogeneous MIAs
2.2 Homogeneous MIAs
3 Application of new synthesis methods in MIAs
3.1 Suspension polymerization
3.2 Precipitation polymerization
3.3 Reversible addition-fragmentation chain transfer(RAFF) polymerization
3.4 Photolithography polymerization
4 Conclusions and outlook

Key words: molecularly imprinted polymer(MIP), sorbent immunoassays, homogeneous immunoassays, new synthesis methods

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[1] Piletsky S A, Alcock S, Turner A P F. Trends Biotechnol., 2001, 19: 9—12
[2] Lavignac N, Allender C J, Brain K R. Anal. Chim. Acta, 2004, 510: 139—145
[3] Ansell R J. J. Chromatogr. B, 2004, 804: 151—165
[4] Ye L, Haupt K. Anal. Bioanal. Chem., 2004, 378: 1887—1897
[5] Piletsky S A, Turner N W, Laitenberger P. Med. Eng. Phys., 2006, 28: 971—977
[6] Xu Z X, Gao H J, Zhang L M, Chen X Q, Qiao X G. J. Food Sci., 2011, 76: R69—R75
[7] Valtakis G, Andersson L I, Müller R, Mosbach K. Nature, 1993, 361: 645—647
[8] Andersson L I, Müller R, Vlatakis G, Mosbach K. Proc. Natl. Acad. Sci. USA, 1995, 92: 4788—4792
[9] Karlsson J G, Karlsson B, Andersson L I, Nicholls I A. Analyst, 2004, 129: 456—462
[10] Benito-Pea, Moreno-Bondi M C, Aparicio S, Orellana G, Cederfur J, Kempe M. Anal. Chem., 2006, 78: 2019—2027
[11] O'Mahony J, Karlsson B C G, Mizaikoff B, Nicholls I A. Analyst, 2007, 132: 1161—1168
[12] Karlsson B C G, Rosengren A M, Nslund I, Andersson P O, Nicholls I A. J. Med. Chem., 2010, 53: 7932—7937
[13] Wiklander J, Karlsson B C G, Aastrup T, Nicholls I A. Anal. Bioanal. Chem., 2011, 400: 1397—1404
[14] Haupt K, Mayes A G, Mosbach K. Anal. Chem., 1998,70: 3936—3939
[15] Haupt K. React. Funct. Polym., 1999, 41: 125—131
[16] Hunt C E, Pasetto P, Ansell R J, Haupt K. Chem. Commun., 2006, 1754—1756
[17] Vandevelde F, Lechlé T, Ayela C, Bergaud C, Nicu L, Haupt K. Langmuir, 2007, 23: 6490—6493
[18] Lu C H, Zhou W H, Han B, Yang H H, Chen X, Wang X R. Anal. Chem., 2007, 79: 5457—5461
[19] Urraca J L, Moreno-Bondi M C, Orellana G, Sellergren B, Hall A J. Anal. Chem., 2007, 79: 4915—4923
[20] Navarro-Villoslada F, Urraca J L, Moreno-Bondi M C, Orellana G. Sens. Actuators B, 2007, 121: 67—73
[21] Surugiu I, Ye L, Yilmaz E, Dzgoev A, Danielsson B, Mosbach K, Haupt K. Analyst, 2000, 125: 13—16
[22] Surugiu I, Danielsson B, Ye L, Mosbach K, Haupt K. Anal. Chem., 2001, 73: 487—491
[23] Piletsky S A, Piletska E V, Chen B, Karim K, Weston D, Barrett G, Lowe P, Turner A P F. Anal. Chem., 2000, 72: 4381—4385
[24] Piletsky S A, Piletska E V, Bossi A, Karim K, Lowe P, Turner A P F. Biosens. Bioelectron., 2001, 16: 701—707
[25] Wang S, Xu Z X, Fang G Z, Zhang Y, Liu B, Zhu H P. J. Agric. Food Chem., 2009, 57: 4528—4534
[26] Fang G Z, Lu J P, Pan M F, Li W, Ren L, Wang S. Food Anal. Methods, 2011, DOI: 10.1007/s12161-011-9206-4
[27] Li J P, Jiang F Y, Li Y P, Chen Z Q. Biosens. Bioelectron., 2011, 26: 2097—2101
[28] Ye L, Surugiu I, Haupt K. Anal. Chem., 2002, 74: 959—964
[29] Ge Y, Turner A P F. Chem. Eur. J., 2009, 15: 8100—8107
[30] González G P, Hernando P F, Alegría J S D. Anal. Bioanal. Chem., 2009, 394: 963—970
[31] Andersson L I. Anal. Chem., 1996, 68: 111—117
[32] Haupt K, Mosbach K. Tibtech, 1998, 16: 468—475
[33] Yilmaz E, Mosbach K, Haupt K. Anal. Commun., 1999, 36: 167—170
[34] Dickert F L, Lieberzeit P, Tortschanoff M. Sens. Actuators B, 2000, 65: 186—189
[35] Lotierzo M, Henry O Y F, Piletsky S, Tothill I, Cullen D, Kania M, Hock B, Turner A P F. Biosens. Bioelectron., 2004, 20: 145—152
[36] Kempe H, Kempe M. Macromol. Rapid Commun., 2004, 25: 315—320
[37] Kempe H, Kempe M. Anal. Chem., 2006, 78: 3659—3666
[38] Zourob M, Mohr S, Maye A G, Macaskill A, Pérez-Moral N, Fielden P R, Goddard N J. Lab Chip, 2006, 6: 296—301
[39] Wei S T, Molinelli A, Mizaikoff B. Biosens. Bioelectron., 2006, 21: 1943—1951
[40] Yoshimatsu K, Reimhult K, Krozer A, Mosbach K, Sode K, Ye L. Anal. Chim. Acta, 2007, 584: 112—121
[41] Yoshimatsu K, Ye L, Lindberg J, Chronakis I S. Biosens. Bioelectron., 2008, 23: 1208—1215
[42] Guillon S, Lemaire R, Linares A V, Haupt K, Ayela C. Lab Chip, 2009, 9: 2987—2991
[43] Cederfur J, Pei Y X, Meng Z H, Kempe M. J. Comb. Chem., 2003, 5: 67—72
[44] 司汴京(Si B J), 陈长宝(Chen C B), 周杰(Zhou J). 化学进展(Progress in Chemistry), 2009, 21(9): 1813—1819
[45] Subralmanyam S, Piletsky S A, Piletska E V. Biosens. Bioelectron., 2001, 16: 631—637
[46] Piletsky S A, Karim K, Piletska E V. Analyst, 2001, 126: 1826—1830
[47] Chianella I, Lotierzo M, Piletsky S A, Tothill I E, Chen B, Karim K, Turner A P F. Anal. Chem., 2002, 74: 1288—1293
[48] Wei S T, Jakusch M, Mizaikoff B. Anal. Chim. Acta, 2006, 578: 50—58
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