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Progress in Chemistry 2012, Vol. 24 Issue (04): 637-649 Previous Articles   Next Articles

• Review •

Chemical Mechanism During Chinese Medicine Processing

Cai Baochang1,2,3, Qin Kunming1,2, Wu Hao1,3, Cai Hao1,3, Lu Tulin1,3, Zhang Xingde1,3   

  1. 1. Engineering Center of State Ministry of Education for Chinese Medicine Processing, Nanjing University of Chinese Medicine, Nanjing 210029, China;
    2. Nanjing Haichang Chinese Medicine Group Co., Ltd, Nanjing 210061, China;
    3. Key Laboratory of State Administration of TCM for Standardization of Chinese Medicine Processing, Nanjing 210046, China
  • Received: Revised: Online: Published:
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Chinese medicine processing is a traditional Chinese pharmaceutical technology, and it is also the main characteristic property that distinguish traditional Chinese medicine and natural medicine. There are complex chemical changes during the process of Chinese medicine processing, and these chemical constituents which changed during processing maybe the basis of clinical efficacy changes. To clarify the changes of the chemical constituents and the chemical reactions in Chinese medicine during the processing process is the main purpose of the chemical mechanism research of Chinese medicine processing. In recent years, many research institutions at home and abroad have done deeply research in chemical mechanism during the process of Chinese medicine processing. The chemaical reactions and chemical mechanisms ocurred in some traditional Chinese medicines during the process of Chinese medicine processing were initially clarified. The main chemical reactions occurred in the Chinese medicine processing are hydrolysis reaction, oxidation reaction, replacement reaction, isomerization reaction, decomposition reaction,etc. The main achievements in the chemical mechanism research during the process of Chinese medicine processing are reviewed. The research directions and future in the chemical mechanism research of Chinese medicine processing are prospected.
Contents
1 Introduction
2 Chemical composition change and its mechanism during Chinese medicine processing
2.1 Hydrolysis reaction
2.2 Isomerization reaction
2.3 Oxidation reaction
2.4 Replacement reaction
2.5 Decomposition reaction
2.6 Condensation reaction
2.7 Others
3 Problems and countermeasures
3.1 Application of modern analytical techniques to explore the Chinese medicine processing mechanism
3.2 Combinational research of chemical analysis and pharmaceutical efficacy mechanism during Chinese medicine processing
3.3 Exploration and establishment of new methods to clarify the mechanisms of Chinese medicine processing
4 Conclusion
Key words: Chinese medicine processing, reaction, chemical constituents, chemical mechanism

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