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Progress in Chemistry 2012, Vol. 24 Issue (04): 589-597 Previous Articles   Next Articles

• Review •

Cytochrome b5-Protein Interactions

Lin Yingwu   

  1. School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, China
  • Received: Revised: Online: Published:
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Protein-protein interactions play crucial roles in biological processes, especially for heme proteins. Cytochrome b5 (Cyt b5) is a typical heme protein, which functions in vivo through various protein-protein interactions. As reviewed herein, the currently revealed interactions associated with Cyt b5 include Cyt b5-Cyt b5 reductase, Cyt b5-Cyt P450, Cyt b5-Cyt c, Cyt b5-myoglobin or hemoglobin, Cyt b5-fusion proteins (glutathione S-transferase, GST, and green fluorescence protein, GFP), and Cyt b5-tansporters (sucrose transporter, SUT1, and sorbital transporter, SOT6), etc. The fact that a single protein can interact with various proteins makes us realize the biological importance of some particular proteins. On the other hand, the study of a single protein interacting with various proteins will further our understanding of protein structure-function relationship, as well as guide rational design of novel proteins for ultimate applications.
Contents
1 Introduction
2 Cytochrome b5
2.1 Structure
2.2 Function
3 Cytochrome b5-protein interactions
3.1 Cytochrome b5-cytochrome b5 reductase
3.2 Cytochrome b5-cytochrome P450
3.3 Cytochrome b5-cytochrome c
3.4 Cytochrome b5-myoglobin or hemoglobin
3.5 Cytochrome b5-fusion protein
3.6 Cytochrome b5-transporter
4 Conclusions and outlook
Key words: cytochrome b5, heme protein, fusion protein, structure, function

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Abstract

Cytochrome b5-Protein Interactions