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Progress in Chemistry 2012, Vol. 24 Issue (01): 61-69 Previous Articles   Next Articles

• Review •

Steroidal Amides with Biological Activities

Huang Yanmin, Cui Jianguo*, Gan Chunfang, Yao Qiucui, Jia Linyi   

  1. College of Chemistry and Life Sciences, Guangxi Teachers Education University, Nanning 530001, China
  • Received: Revised: Online: Published:
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The compounds with different bioactivities are obtained when some different functional groups are introduced into a nucleus or side chain of a steroid and they may become new drugs to treat different diseases. Besides applying to hormonal drugs, some steroidal compounds have exhibited a broad spectrum of biologic activities, such as antibacterium, inhibition of 5α-reductase and anti-tumor activities. Some modified steroidal compounds, such as steroidal amides that contain —NHCO— group, exhibit valuable biological activities and become an important research field of steroidal medicinal chemistry. Combined with our investigation, the studies on biological and physiological functions of the steroidal amides in recent years have been reviewed according to the location of different substituent groups on steroid, including the design and screening of the steroidal amides as cytotoxic agents, 5α-reductase inhibitors and antibiotics.

Contents
1 Introduction
2 Steroidal amides with biological activities
2.1 Aza-A-homo-steroidal amides
2.2 Aza-B-homo-steroidal amides
2.3 Aza-C-homo-steroidal amides
2.4 Aza-D-homo-steroidal amides
2.5 Steroidal side chain amides
3 Outlook

Key words: steroidal amides, anti-tumor agents, 5α-reductase inhibitors, antibiotics

CLC Number: 

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