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Progress in Chemistry 2012, Vol. Issue (9): 1707-1719 Previous Articles   Next Articles

• Review •

Multinuclear Anticancer Platinum Complexes

Xu Gang1,2, Jiang Pingyuan1,2, Gou Shaohua1,2   

  1. 1. School of Chemistry and Chemical Engineering, Nanjing 211189, China;
    2. Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research, Nanjing 211189, China
  • Received: Revised: Online: Published:
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Multinuclear platinum anticancer complexes have been investigated intensively due to their novel structures and promising anticancer activities. Moreover, they are able to overcome cisplatin resistance because of their abilities to form different adducts with DNA compared with those formed by cisplatin. The research status of dinuclear and multinuclear anticancer platinum complexes is reviewed. Based on the different linking ligands, dinuclear and multinuclear are divided to six types, namely, alkyl diamines and their derivatives, heterocyclic compounds containing nitrogen atom(s), carboxylates, haloid anions, ligands containing sulfur atom(s) and other ligands. The possible anticancer mechanism and structure-activity relationship of these multinuclear platinum complexes are also discussed in this paper. Contents 1 Introduction
2 Diamines and their derivatives as linking ligands
2.1 Flexible diamines
2.2 Polyamines
2.3 Semi-rigid diamines and polyamines
3 Heterocycles containing nitrogen atom(s) as linking ligands
3.1 Pyrazole and its derivatives
3.2 Pyrazine and its derivatives
3.3 Bipyridine and its derivatives
3.4 Pyrimidine and its derivatives
3.5 Macrocyclic polyamines
4 Haloid anions as linking ligands
5 Carboxylates as linking ligands
6 Linking ligands containing sulfur atom(s)
7 Other linking ligands
8 Conclusions and outlook

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Abstract

Multinuclear Anticancer Platinum Complexes