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Progress in Chemistry 2012, Vol. Issue (10): 1936-1945 Previous Articles   Next Articles

• Review •

Organizing Functional Nanomaterials with DNA Origami

Wang Jinye1, Song Chen2, Xu Jingkun1*, Ding Baoquan2*   

  1. 1. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science and Technology Normal University, Nanchang 330013, China;
    2. National Center for Nanoscience and Technology, Beijing 100190, China
  • Received: Revised: Online: Published:
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DNA origami,an efficient self-assembly technique, has shown great potential for applications in biomedicine, biosensing, nanooptoelectronic device and nanophotonics. It has received strong attention from researchers in a wide range of fields. The programmability and three dimensional addressability of DNA origami architectures have been utilized to precisely organize various functional groups, such as metallic nanoparticles, semiconducting nanoparticles,protein molecules and single-wall carbon nanotubes. Meanwhile, DNA origami structures have also been employed to investigate single molecule reactions on them, such as label-free RNA hybridization, formation and break of a chemical bond and distance-dependent multivalent ligand-protein binding. In the present paper, the research progress of organizing functional nanomaterials with DNA origami are reviewed, and the challenges and application prospects are discussed. Contents 1 Introduction
2 Functional groups organized by DNA origami
2.1 Metallic nanoparticles and semiconducting quantum dots self-assembled on DNA origami
2.2 Protein molecules self-assembled on DNA origami
2.3 Single-wall carbon nanotubes self-assembled on DNA origami
3 DNA origami combining with lithography technology
4 DNA origami for single-molecule reaction detection
5 Conclusion and outlook
Key words: DNA origami, self-assembly, metal nanoparticles, quantum dots, proteins, single-wall carbon nanotubes, single molecular reaction

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