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Progress in Chemistry 2012, Vol. Issue (10): 1928-1935 Previous Articles   Next Articles

• Review •

Ionic Liquids in Pharmaceuticals

Yang Tingting, Gao Guohua*   

  1. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, China
  • Received: Revised: Online: Published:
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In order to solve the problems associated with the solid form of conventional pharmaceuticals including polymorphic conversion, low solubility, low bioavailability, and the tendency of amorphous forms to spontaneously crystallize, the liquid form pharmaceuticals have attracted much attention. Recent developments of ionic liquids (ionic liquids are loosely defined as salts with melting points below 100℃) might prove beneficial. Ionic liquids exhibit controlled solubility, unique surface activity, high thermostability and enhancement in bioavailability or bioactivity, which make ionic liquids have the advantage of elimination of polymorphism, new delivery options, or having customized pharmaceutical cocktails. In some cases, an active cation and an active anion can be combined to produce a liquid possessing dual functionality. These make ionic liquids have the possibility of being used in the pharmaceutical industry. The aim of this mini-review is to summarize the recent development of ionic liquids as active pharmaceutical ingredients, antimicrobial agents and agriculture chemicals, and discuss the existing problems and the future research of ionic liquids in pharmaceuticals. Contents 1 Introduction
2 Ionic liquids as active pharmaceutical ingredients
3 Ionic liquids as antimicrobial agents
3.1 Antimicrobial activity of imidazolium and pyridinium ionic liquids
3.2 Antimicrobial activity of other kinds of ionic liquids
4 Ionic liquids as agriculture chemicals
5 Conclusion and outlook
Key words: ionic liquids, active pharmaceutical ingredients(APIs), antimicrobial agents, herbicides

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[1] P rvulescu V I, Hardacre C. Chem. Rev., 2007, 107: 2615-2665
[2] Zhao D, Wu M, Kou Y, Min E. Catal. Today, 2002, 74: 157-189
[3] Hallett J P, Welton T. Chem. Rev., 2011, 111: 3508-3576
[4] Zhang Q H, Zhang S G, Deng Y Q. Green Chem., 2011, 13: 2619-2637
[5] Vidala L, Riekkolaa M L, Canals A. Anal. Chim. Acta, 2012, 715: 19-41
[6] Mecerreyes D. Prog. Polym. Sci., 2011, 36: 1629-1648
[7] 孟坤燕(Meng K Y), 齐明辉(Qi M H), 陈宜俍(Chen Y L), 赵文杰(Zhao W J), 任国宾(Ren G B). 中国抗生素杂志(Chinese Journal of Antibiotics), 2011, 36(11): 801-805
[8] Hough W L, Smiglak M, Rodríguez H, Swatloski R P, Spear S K, Daly D T, Pernak J, Grisel J E, Carliss R D, Soutullo M D, Davis J H Jr, Rogers R D, Pernak J. New J. Chem., 2007, 31: 1429-1436
[9] 李胜海(Li S H), 张所波(Zhang S B). CN 1970543A, 2007
[10] Malhotra S V, Kumar V. Bioorg. Med. Chem. Lett., 2010, 20: 581-585
[11] Stoimenovski J, MacFarlane D R, Bica K, Rogers R D. Pharm. Res., 2010, 27: 521-526
[12] Hough W L, Rogers R D. Bull. Chem. Soc. Jpn., 2007, 80: 2262-2269
[13] Restolho J, Mata J L, Saramago B. J. Chem. Phys., 2011, 134: art. no. 074702
[14] Dean P M, Turanjanin J, Yoshizawa-Fujita M, MacFarlane D R, Scott J L. Cryst. Growth Des., 2009, 9: 1137-1145
[15] Bica K, Rogers R D. Chem. Commun., 2010, 46: 1215-1217
[16] Weaver K D, Kim H J, Sun J Z, MacFarlane D R, Elliott G D. Green Chem., 2010, 12: 507-513
[17] Cole M R, Li M, EL-Zahab B, Janes M E, Hayes D, Warner I M. Chem. Biol. Drug Des., 2011, 78: 33-41
[18] Quijano G, Couvert A, Amrane A. Bioresour. Technol., 2010, 101: 8923-8930
[19] Ranke J, Stolte S, Störmann R, Arning J, Jastorff B. Chem. Rev., 2007, 107: 2183-2206
[20] Zhao D B, Liao Y C, Zhang Z D. Clean-Soil, Air, Water, 2007, 35: 42-48
[21] 柯明(Ke M), 周爱国(Zhou A G), 宋昭峥(Song Z Z), 蒋庆哲(Jiang Q Z). 化学进展(Progress in Chemistry), 2007, 19(5): 671-679
[22] Carson L, Chau P K W, Earle M J, Gilea M A, Gilmore B F, Gorman S P, McCann M T, Seddon K R. Green Chem., 2009, 11: 492-497
[23] uczak J, Jungnickel C, acka I, Stolte S, Hupka J. Green Chem., 2010, 12: 593-601
[24] Docherty K M, Kulpa C F Jr. Green Chem., 2005, 7: 185-189
[25] Pernak J, Sobaszkiewicz K, Mirska I. Green Chem., 2003, 5: 52-56
[26] Pernak J, Goc I, Mirska I. Green Chem., 2004, 6: 323-329
[27] Cornellas A, Perez L, Comelles F, Ribosa I, Manresa A, Garcia M T. J. Colloid Interface Sci., 2011, 355: 164-171
[28] Feder-Kubis J, Kubicki M, Pernak J. Tetrahedron: Asymmetry, 2010, 21: 2709-2718
[29] Alberto E E, Rossato L L, Alves S H, Alves D, Braga A L. Org. Biomol. Chem., 2011, 9: 1001-1003
[30] Pernak J, Smiglak M, Griffin S T, Hough W L, Wilson T B, Pernak A, Zabielska-Matejuk J, Fojutowski A, Kita K, Rogers R D. Green Chem., 2006, 8: 798-806
[31] Cybulski J, Wi Ds＇ niewska A, Kulig-Adamiak A, Lewicka L, Cieniecka-Rosonkiewicz A, Kita K, Fojutowski A, Nawrot J, Materna K, Pernak J. Chem. Eur. J., 2008, 14: 9305-9311
[32] Cybulski J, Wi Ds＇ niewska A, Kulig-Adamiak A, D Ds＇ browski Z, Praczyk T, Michalczyk A, Walkiewicz F, Materna K, Pernak J. Tetrahedron Lett., 2011, 52: 1325-1328
[33] Hossain M I, El-Harbawi M, Noaman Y A, Bustam M A B, Alitheen N B M, Affandi N A, Hefter G, Yin C Y. Chemosphere, 2011, 84: 101-104
[34] Saadeh S M, Yasseen Z, Sharif F A, Shawish H M A. Ecotoxicol. Environ. Saf., 2009, 72: 1805-1809
[35] Walkiewicz F, Materna K, Kropacz A, Michalczyk A, Gwiazdowski R, Praczyk T, Pernak J. New J. Chem., 2010, 34: 2281-2289
[36] Cieniecka-Rosonkiewicz A, Pernak J, Kubis-Feder J, Ramani A, Robertson A J, Seddon K R. Green Chem., 2005, 7: 855-862
[37] Busetti A, Crawford D E, Earle M J, Gilea M A, Gilmore B F, Gorman S P, Laverty G, Lowry A F, McLaughlin M, Seddon K R. Green Chem., 2010, 12: 420-425
[38] Hough-Troutman W L, Smiglak M, Griffin S, Reichert W M, Mirska I, Jodynis-Liebert J, Adamska T, Nawrot J, Stasiewicz M, Rogers R D, Pernak J. New J. Chem., 2009, 33: 26-33
[39] Pernak J, Syguda A, Janiszewska D, Materna K, Praczyk T. Tetrahedron, 2011, 67: 4838-4844
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Ionic Liquids in Pharmaceuticals