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Progress in Chemistry 2011, Vol. 23 Issue (9): 1973-1984 Previous Articles   Next Articles

• Review •

Monodisperse Mesoporous Silica Nanoparticles: Synthesis and Application in Biomaterials

Tang Shiyang1, Sun Xiaojun1, Lin Li2, Sun Yan2*, Liu Xianbin1*   

  1. 1. Key Laboratory of Green Chemical Technology of Heilongjiang Province, The School of Chemistry and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040,China;
    2. Department of Life Science and Engineering, Harbin Institute of Technology, Harbin 150001, China
  • Received: Revised: Online: Published:
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Monodisperse mesoporous silica nanoparticles are of promising applications in many current and emerging areas of technology because of their nature advantages. This review is devoted to the progress made in the last decade in synthesis and biomedical application of monodisperse mesoporous silica nanoparticles. We present a comprehensive overview of synthetic strategies for monodisperse mesoporous silica nanoparticles. These strategies are broadly categorized into three groups, such as dilute solution method, microemulsion method, and introduction of template/different additives to reaction system. Monodisperse mesoporous silica nanoparticles with good dispersion, different morphology and tuning pore sizes are successfully synthesized by means of the above-mentioned methods. Applications of monodisperse mesoporous silica nanoparticles in drug and large biomolecule delivery and controlled release, separation of the large bimolecular, biomarker and biomedical diagnosis are mostly described.

Contents
1 Introduction
2 Preparation of monodisperse mesoporous silica nanoparticles
2.1 Dilute solution method
2.2 Microemulsion method
2.3 Introduction of template/different additives
3 Application of monodisperse mesoporous silica nanoparticles
3.1 Loading and controlled release of drugs and large bimolecular
3.2 Separation of large biomacromolecule
3.3 Biomarker and biomedical diagnosis
4 Conclusion and outlook

 

Key words: monodisperse, mesoporous silica, nanoparticles, synthesis, biomaterials

CLC Number: 

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