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Progress in Chemistry 2011, Vol. 23 Issue (9): 1945-1958 Previous Articles   Next Articles

• Review •

Application of Inertial Effect in Microfluidic Chips

Xiang Nan, Zhu Xiaolu, Ni Zhonghua*   

  1. Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing 211189, China
  • Received: Revised: Online: Published:
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As a new approach to precisely manipulate particles or fluids, the manipulation technology based on fluid inertia has numerous microfluidic applications in particle transporting, sorting, focusing, and sample mixing. The inertial microfluidic chips can be used to solve a variety of real-world problems in clinical diagnostics, biochemical analysis, synthetic chemistry and environmental monitoring due to the advantages offered by microscale inertial effects, such as high throughput, operation without external fields, low cost, inherent miniaturization and portability. Therefore, the inertial microfluidics has attracted increasing interest and shows a promising future for a variety of applications. In this review, the theories of inertial microfluidics are briefly described, and recent advances in applications of inertial microfluidics are presented and compared including inertial focusing, inertial sorting, Dean flow-assisted micromixers and optofluidic lens. Limitations and prospects of inertial microfluidics are also discussed.

Contents
1 Introduction
2 Mechanisms and key technologies of inertial microfluidic chip
2.1 Inertial migration
2.2 Dean flow
2.3 Movements and equilibrium positions of particles in channel
2.4 Key technologies for the development of inertial microfluidic chip
3 Latest developments in applications of inertial microfluidics
3.1 Inertial focusing
3.2 Inertial sorting
3.3 Other applications
4 Conclusion and prospects

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