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Progress in Chemistry 2011, Vol. 23 Issue (7): 1527-1533 Previous Articles   Next Articles

• Special issues •

Radioanalytical Methods in Nanotoxicology Studies

Zhang Zhiyong*, Zhao Yuliang, Chai Zhifang   

  1. Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, The Chinese Academy of Sciences, Beijing 100049, China
  • Received: Revised: Online: Published:
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With the rapid development of nanotechnology and its applications, the potential interactions of nanomaterials with living systems and the environment have attracted increasing attention from the public, as well as from manufacturers of nanomaterial-based products, academic researchers and policymakers. Nanotoxicology is emerging as an important subdiscipline of nanotechnology as well as toxicology. Nanotoxicology studies rely on many analytical methods for the characterization of nanomaterials and detection of nanomaterials in living systems. In this case, radioanalytical methods can play an important role due to their intrinsic merits such as high sensitivity, good accuracy, ability to distinguish the endogenous or exogenous sources of materials, and ability of in situ and in vivo analysis. This article reviews recent progress of applications of radioanalytical methods in nanotoxicology studies, and the emphasis is radiolabeling methods of nanomaterials.

Contents
1 Introduction
2 Chemical impurity analysis of carbon nanotubes using neutron activation analysis
3 Radiolabelling of nanomaterials for in vivo radiotracer studies
3.1 Radiolabeling of carbon nanomaterials
3.2 Radiolabeling of metallic and metal oxide nanomaterials
3.3 Radiolabeling of nanomedicines and other nanoparticles
4 Conclusions and outlook

Key words: radioanalytical methods, nanotoxicology, nanomaterials

CLC Number: 


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