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Progress in Chemistry 2011, Vol. 23 Issue (7): 1493-1500 Previous Articles   Next Articles

• Special issues •

Technetium-99m Radiopharmaceutical Chemistry

Mei Lei, Chu Taiwei*   

  1. Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China
  • Received: Revised: Online: Published:
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Technetium based radiopharmaceuticals have been widely used in scientific research and clinic. A large amount of new radiopharmaceuticals have been exploited and used. However, how to develop pharmaceuticals with better treatments and wider applicability to meet the need of clinic is still an urgent problem. The introduction of new ligands and cores and development of new strategies of labeling have become a hot subject in the technetium based radiopharmaceutical field. In order to provide some references to the researchers,introduction of some new labeling methods used for technetium-99m-labeled radiopharmaceuticals, including new ligands and methods for 99mTc-tricarbonyl technetium labeling, preparation and application of the high-valent technetium, are carried out in this paper.

Contents
1 Introduction
2 Recent progress of labeling with tricarbonyl technetium
2.1 New ligands for labeling of tricarbonyl technetium
2.2 New strategy for labeling of tricarbonyl technetium
3 Complex of high-valent technetium
4 Conclusion and outlook

Key words: radiopharmaceutical chemistry, labeling, tricarbonyl technetium, high-valent technetium

CLC Number: 


[1] Reichert D E, Lewis J S, Anderson C J. Coord. Chem. Rev., 1999, 184: 3-66

[2] Banerjee S, Pillai M R A, Ramamoorthy N. Semin. Nucl. Med., 2001, 31: 260-277

[3] Jurisson S S, Lydon J D. Chem. Rev., 1999, 99: 2205-2218

[4] Liu S, Edwards D S. Top. Curr. Chem., 2002, 222: 259-278

[5] Neirinckx R D, Canning L R, Piper I M, Nowotnik D P, Pickett R D, Holmes R A, Volkert W A, Forster A M, Weisner P S, Marriott J A, Chaplin S B. J. Nucl. Med., 1987, 28: 191-202

[6] Jurisson S, Berning D, Jia W, Ma D. Chem. Rev., 1993, 93: 1137-1156

[7] Williams S J, Mousa S A, Morgan R A, Carroll T R, Maheu L J. J. Nucl. Med., 1986, 27: 877-878

[8] Liu S. Chem. Soc. Rev., 2004, 33: 1-18

[9] Schibli R, Schubiger P A. Eur. J. Nucl. Med., 2002, 29: 1529-1542

[10] Alberto R, Schibli R, Egli A, Schubiger A P, Abram U, Kaden T A. J. Am. Chem. Soc., 1998, 120: 7987-7988

[11] Alberto R. Eur. J. Inorg. Chem., 2009, 21-31

[12] Wald J, Alberto R, Ortner K, Candreia L. Angew. Chem., Int. Ed., 2001, 40: 3062-3066

[13] Liu Y, Spingler B, Schmutz P, Alberto R. J. Am. Chem. Soc., 2008, 130: 1554-1555

[14] N'Dongo H W P, Can D, Liu Y, Schmutz P, Spingler B, Alberto R. J. Organomet. Chem., 2009, 694: 981-987

[15] N'Dongo H W P, Raposinho P D, Fernandes C, Santos I, Can D, Schmutz P, Spingler B, Alberto R. Nucl. Med. Biol., 2010, 37: 255-264

[16] Masi S, Top S, Boubekeur L, Jaouen G, Mundwiler S, Spingler B, Alberto R. Eur. J. Inorg. Chem., 2004, 2013-2017

[17] Maria L, Paulo A, Santos I C, Santos I, Kurz P, Spingler B, Alberto R. J. Am. Chem. Soc., 2006, 128: 14590-14598

[18] Stephenson K A, Zubieta J, Banerjee S R, Levadala M K, Taggart L, Ryan L, McFarlane N, Boreham D R, Maresca K P, Babich J W, Valliant J F. Bioconjugate Chem., 2004, 15: 128-136

[19] Stephenson K A, Banerjee S R, Besanger, T, Sogebin O O, Levadala M K, McFarlane N, Lemon J A, Boreham D R, Maresca K P, Brennan J D, Babich J W, Zubieta J, Valliant J F. J. Am. Chem. Soc., 2004, 126: 8598-8599

[20] Maresca K P, Hillier S M, Femia F J, Zimmerman C N, Levadala M K, Banerjee S R, Hicks J, Sundararajan C, Valliant J, Zubieta J, Eckelman W C, Joyal J L, Babich J W. Bioconjugate Chem., 2009, 20: 1625-1633

[21] Liu Y, Pak J K, Schmutz P, Bauwens M, Mertens J, Knight H, Alberto R. J. Am. Chem. Soc., 2006, 128: 15996-15997

[22] Kolb H C, Finn M G, Sharpless K B. Angew. Chem. Int. Ed., 2001, 40: 2004-2021

[23] Kolb H C, Sharpless K B. Drug Discov. Today, 2003, 8: 1128-1137

[24] Ramenda T, Kniess T, Bergmann R, Steinbach J, Wuest F. Chem. Commun., 2009, 7521-7523

[25] Mindt T L, Struthers H, Brans L, Anguelov T, Schweinsberg C, Maes V, Tourwe D, Schibli R. J. Am. Chem. Soc., 2006, 128: 15096-15097.

[26] Mindt T L, Müller C, Melis M, de Jong M, Schibli R. Bioconjugate Chem. 2008, 19: 1689-1695

[27] Struthers H, Spingler B, Mindt T L, Schibli R. Chem. Eur. J., 2008, 14: 6173-6183

[28] Schibli R, La Bella R, Alberto R, Garcia-Garayoa E, Ortner K, Abram U, Schubiger P A. Bioconjugate Chem., 2000, 11: 345-351

[29] Rattat D, Eraets K, Cleynhens B, Knight H, Fonge H, Verbruggen A. Tetrahedron Lett., 2004, 45: 2531-2534

[30] Mundwiler S, Kgndig M, Ortner K, Alberto R. Dalton Trans., 2004, 1320-1328

[31] Kunze S, Zobi T, Kurz P, Spingler B, Alberto R. Angew. Chem. Int. Ed., 2004, 43: 5025-5029

[32] Agorastos N, Borsig L, Renard A, Antoni P, Viola G, Spingler B, Kurz P, Alberto R. Chem. Eur. J., 2007, 13: 3842-3852

[33] Braband H, Tooyama Y, Fox T, Alberto R. Chem. Eur. J., 2009, 15: 633-638
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