中文
Earlier issues
Announcement
More
Progress in Chemistry 2011, Vol. 23 Issue (5): 983-990 Previous Articles   Next Articles

• Review •

Apoptotic Signal Pathways of Tumor Cells Induced by Ruthenium Complexes and Its Mechanisms

Zhang Xiaonian, Liu Yanan, Yang Xiaoxin, Liu Jie   

  1. Department of Chemistry, College of Life Science and Technology, Jinan University, Guangzhou 510632, China
  • Received: Revised: Online: Published:
PDF ( 1210 ) Cited
Export

EndNote

Ris

BibTeX

As anticancer drugs, ruthenium complexes have received wide attention at home and abroad.In recent years, the design and synthesis of new types of complexes,the regulatory role of complexes in apoptosis, signal transduction, and gene expression have become a new hotspot, and its mechanisms of anticancer activity of metal complexes have been further explained. This paper mainly reviews ruthenium complexes, including their effect to induce the apoptosis of various types of tumor cell and their mechanism that induces apoptosis in current studies. The main text includes the following: the anti-cancer mechanism of the ruthenium complexes which had accessed to clinical (Ⅰ, Ⅱ); the cell cycle arrest induced by ruthenium complexes; the endogenous mitochondrial damage, the endoplasmic reticulum stress and other signal transduction pathway which induced tumor cell apoptosis; regulating the expression of the pathway-related proteins; regulating the expression and activity of these proteins which are related to the cell apoptosis or the cell proliferation.

Key words: ruthenium complexes, anti-tumor activity, apoptosis, signaling pathway, protein regulation of apoptosis

CLC Number: 

[1] Hideo F, Masaki Y, Takao A, Satoshi S, Shuzo S. Neuropharmacol., 1993, 32: 959-968
[2] Zhang C X, Lippard S. J. Curr. Opin. Chem. Biol., 2003, 7: 481-489
[3] Clark M. J. Coord. Chem. Rev., 2002, 232: 69-93
[4] Bergamo A, Sava G. Dalton. Trans., 2007, 1267-1272
[5] Sava G, Bergamo A, Zorzet S, Gava B, Casarsa C, Cocchietto M, Furlani A, Scarcia V, Serli B, Iengo E, Alessio E, Mestroni G. Eur. J. Cancer., 2002,38:427-435
[6] Bergamo A, Gagliardi R, Scarcia V, Furlani A, Alessio E, Mestroni G, Sava G. Pharm. Exp. Ther., 1999, 289: 559-564
[7] Serli B, Iengo E, Gianferrara T, Zangrando E, Alessio E. Metal Based Drugs., 2001, 8: 9-18
[8] Alessio E, Iengo E, Zorzet S, Bergamo A, Coluccia M, Boccarelli A, Sava G. J. Inorg. Biochem., 2000, 79: 157-161
[9] Sava G, Bergamo A. Zorzet S, Gava B, Casarsa C, Cocchietto M, Furlani A, Scarcia V, Serli B, Iengo E, Alessio E, Mestroni G, Eur. J. Cancer., 2002, 38: 427-435
[10] Kostova I. Curr. Med. Chem., 2006, 13: 1085-1107
[11] Hartinger C G, Zorbas-Seifried S, Jakupec M A, Zorbas H, Keppler B K. J. Inorg. Biochem., 2006, 100: 891-904
[12] Alessio E, Mestroni G, Bergamo A, Sava G, Curr. Top. Med. Chem., 2004, 4: 1525-1535
[13] Bergamo A, Gagliardi R, Scarcia V, Furlani A, Alessio E, Mestroni G, Sava G. J. Pharmacol. Exp. Ther., 1999, 289: 559-564
[14] Vacca A, Bruno M, Boccarelli A, Coluccia M, Ribatti D, Bergamo A, Garbisa S, Sartor L, Sava G. Br. J. Cancer, 2002, 86: 993-998
[15] Bergamo A, Sava G. Dalton Trans., 2007, 13: 1267-1272
[16] Chatterjee S, Kundu S, Bhattacharyya A, Hartinger C G, Dyson P J. J. Biol. Inorg. Chem., 2008, 13: 1149-1155
[17] Hayward R L, Schornagel Q C, Tente R, Macpherson J S, Aird R E, Guichard S, Habtemariam A, Sadler P, Jodrell D I. Cancer. Chemother. Pharmacol., 2005, 55: 577-583
[18] Gaiddon C, Jeannequin P, Bischoff P, Pfeffer M, Sirlin C, Loeffler J P. J. Pharmacol. Exp. Ther., 2005, 315: 1403-1411
[19] Bergamo A, Gagliardi R, Scarcia V, Furlani A, Alessio E, Mestroni G, Sava G. J. Pharmacol. Exp. Ther., 1999, 289: 559-564
[20] Das S, Sinha S, Britto R, Somasundaram K, Samuelson A G. J. Inorg. Biochem., 2010, 104: 93-104
[21] Liu Y N, Chen T F, Wong Y S, Mei W J, Huang X M, Yang F, Liu J, Zheng W J. Chemico-Biological Interactions, 2010, 183: 349-356
[22] Wang X D. Genes Dev., 2001, 15: 2922-2933
[23] Kapitza S, Pongratz M, Jakupec M A, Heffeter P, Berger W, Lackinger L, Keppler B K, Marian B. J. Cancer Res. Clin. Oncol., 2005, 131: 101-110
[24] 刘杰 (Liu J), 计亮年 (Ji L N), 梅文杰 (Mei W J). 化学进展(Progress in Chemistry), 2004, 16: 969-974
[25] Ang W H, Dyson P J. Eur. J. Inorg. Chem., 2006, 4003-4018
[26] Scolaro C, Bergamo A, Brescacin L, Delfino R, Cocchietto M, Laurenczy G, Geldbach T J, Sava G, Dyson P J. J. Med. Chem., 2005, 48: 4161-4171
[27] Scolaro C, Geldbach T J, Rochat S, Dorcier A, Gossens C, Bergamo A, Cocchietto M, Tavernelli I, Sava G, Rothlisberger U, Dyson P J. Organometallics, 2006, 25: 756-765
[28] Scolaro C, Chaplin A B, Hartinger C G, Bergamo A, Cocchietto M, Keppler B K, Sava G, Dyson P J. Dalton Trans., 2007, 43: 5065-5072
[29] Dorcier A, Dyson P J, Gossens C, Rothlisberger U, Scopelliti R, Tavernelli I. Organometallics, 2005, 24: 2114-2123
[30] Ang W H, Daldini E, Scolaro C, Scopelliti R, Juillerat J L, Dyson P J. Inorg. Chem., 2006, 45: 9006-9013
[31] Sava G, Bergamo A. Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy, 2009. 57-66
[32] Morris R E, Aird R E, Murdoch P S, Chen H M, Cummings J, Hughes N D, Parsons S, Parkin A, Boyd G, Jodrell D I, Sadler P J. J. Med. Chem., 2001, 44: 3616-3621
[33] Smalley K S. M, Contractor R, Haass N K, Kulp A N, Gokcumen G E A, Williams D S, Bregman H, Flaherty K T, Soengas M S, Meggers E, Herlyn M. Cancer. Res., 2007, 67: 209-217
[34] Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N. Science, 2000, 288: 1053-1058
[35] Chen T F, LiuY N, Zheng W J, Liu J, Wong Y S. Inorg. Chem., 2010, 49: 6366-6368
[36] Breckenridge D G. Germain M, Mathai J P, Nguyen M, Shore G C. Oncogene, 2003, 22: 8608-8618
[37] Kadowaki H, Nishitoh H, Chijo H I. J. Chem. Neuroanat., 2004, 28: 93-100
[38] Casini A, Gabbiani C, Sorrentino F, Rigobello M P, Bindoli A, Geldbach T J, Marrone A, Re N, Hartinger C G, Dyson P J, Messori L. J. Med. Chem., 2008, 51: 6773-6781
[39] Meng X G, Leyva M L, Jenny M, Gross I, Benosman S, Fricker B, Harlepp S, Heébraud P, Boos A, Wlosik P, Bischoff P, Sirlin C, Pfeffer M, Loeffler J P, Gaiddon C. Cancer Res., 2009, 69: 5458-5466
[40] Blume J P, Hunter T. Nature, 2001, 411: 355-365
[41] Tamaoki T, Nomoto H, Takahashi I, Kato Y, Morimoto M; Tomita F, Biochem. Biophys. Res. Commun., 1986, 135: 397-402
[42] Williams D S, Atilla G E, Bregman H, Arzoumanian A, Klein P S, Meggers E. Angew. Chem. Int. Ed. Engl., 2005, 44: 1984-1987
[43] Ghosh J C, Altieri D C. Clin. Cancer Res., 2005, 11: 4580-4588
[44] Tan T T, Degenhardt K, Nelson D A, Beaudoin B, Nieves-Neira W, Bouillet P, Villunger A, Adams J M, White E. Cancer Cell, 2005, 7: 227-238
[45] Pluquet O, Qu L K, Baltzis D, Koromilas A E. Mol. Cell Biol., 2005, 25: 9392-9405
[46] Kulikov R, Boehme K A, Blattner C. Mol. Cell. Biol., 2005, 25: 7170-7180
[47] 殷菲(Yin F), 刘建辉(Liu J H), 彭孝军(Peng X J). 化学通报(Chemistry), 2004, 4: 271-277
[48] Rajput C, Rutkaite R, Swanson L, Haq I, Thomas J A. Chem. Eur. J., 2006, 12: 4611-4619
[49] Shi S, Zhao J, Geng X T, Yao T M, Huang H L, Liu T L, Zheng L F, Li Z H, Yang D J, Ji L N. Dalton Trans., 2010, 39: 2490-2493
[50] Xu L, Zhang D, Huang J, Deng M G, Zhang M, Zhou X. Chem. Commun., 2010, 743-745
[51] Rickling S, Ghisdavu L, Pierard F, Gerbaux P, Surin M, Murat P, Defrancq E, Moucheron C, de Mesmaeker A K. Chem. Eur. J., 2010, 16: 3951-3961
[52] Shi S, Liu J, Yao T M, Geng X T, Jiang L F, Yang Q Y, Cheng L, Ji L N. Inorg. Chem., 2008, 47: 2910-2912
[53] Mei W J, Wei X Y, Liu Y J, Wang B. Transition. Met. Chem., 2008, 33: 907-910
[54] Malonne H, Atassi G. Anti-Cancer Drugs, 1997, 8: 811-822
[55] Vashisht G Y N, Jayaraju D, Kondapi A K. Biochemistry, 1999, 38: 4382-4388
[56] Vashisht G Y N, Kondapi A K. J. Biosci., 2001, 26: 271-276
[57] Gao F, Chao H, Wang J Q, Yuan Y X, Sun B, Wei Y F, Peng B, Ji L N. J. Bio. Inorg. Chem., 2007, 12: 1015-1027
[58] Gao F, Chao H, Zhou F, Chen X, Wei Y F, Ji L N. J. Inorg. Biochem., 2008, 102: 1050-1059
[59] Sharma S, Singh S K, Pandey D S. Inorg. Chem., 2008, 47: 1179-1189
[60] Singh S K, Joshi S, Singh A R, Saxena J K, Pandey D S. Inorg. Chem., 2007, 46: 10869-10876
[61] Loughrey B T, Williams M L, Healy P C, Innocenti A, Vullo D, Supuran C T, Parsons P G, Poulsen S A. J. Biol. Inorg. Chem., 2009, 14: 935-945
[62] Zhang L L, Carroll P, Meggers E. Org. Lett., 2004, 6: 521-523
[1] Xinyu Wang, Fuping Zhao, Ru Zhang, Ziru Sun, Shengnan Liu, Qingzhi Gao. Development of Hypoxia Inducible Factor-1 Small Molecule Inhibitors as Antitumor Agents [J]. Progress in Chemistry, 2021, 33(12): 2259-2269.
[2] Xiang Li, Jiayuan Shi, Shuang Qiu, Mingfang Wang, Changlin Liu*. SOD1 Inhibition Regulates the ROS Signaling Transduction [J]. Progress in Chemistry, 2018, 30(10): 1475-1486.
[3] Jiang Ge, Luo Feng, Xu Yaozhong, Zhang Xiaohui. UVA Assisted 4-Thiothymidine for Cancer Treatment [J]. Progress in Chemistry, 2016, 28(8): 1224-1237.
[4] Ye Jiqing, Yue Xiaohong, Sun Liping. Small Molecule Inhibitors of IL-6/STAT3 Signaling [J]. Progress in Chemistry, 2016, 28(7): 1099-1111.
[5] Wang Jiamin, Shi Lei, Liu Haiyang. The Interaction of Corrole and Its Metal Complex with DNA and Their Anti-Tumor Activity [J]. Progress in Chemistry, 2015, 27(6): 755-762.
[6] Cui Jianguo, Liu Liang, Gan Chunfang, Xiao Qi, Huang Yanmin. Synthesis and Biological Activity of Steroids Bearing Aromatic Rings and Heterocycles [J]. Progress in Chemistry, 2014, 26(0203): 320-333.
[7] Chen Yu Du Kejie Chao Hui Ji Liangnian. New Trends for Ruthenium Complexes with Anticancer Activity [J]. Progress in Chemistry, 2009, 21(05): 836-844.
[8] Wang Kui Yang Xiaogai. Safety Issues of Lanthanides-Based Compounds as Diagnostic and Therapeutic Agents as Viewed from Cellular Inorganic Chemistry [J]. Progress in Chemistry, 2009, 21(05): 803-818.
[9] Fan Jian, Zhang Hualin, Tan Chunyan, Jiang Yuyang**. Small Molecules Targeting Tumor Apoptosis Related Proteins and Genes [J]. Progress in Chemistry, 2007, 19(012): 1955-1964.
[10] Liu Jie**,Ji Liangnian,mei Wenjie. The Development of Ruthenium Complexes as Anticancer Drugs Activation and Anticancer Mechanism [J]. Progress in Chemistry, 2004, 16(06): 969-.
[11] Wang Zhongming,Ji Liangnian**. Progress of Ruthenium-Based Antitumor Complexes [J]. Progress in Chemistry, 2002, 14(04): 296-.
[12] Xu Huibi,Yang Xiangliang,Liu Qiong,Wang Haitao,Gan Lu. The Signal Transduction in ROS-Mediated Apoptosis Induced by Selenium Compounds [J]. Progress in Chemistry, 2002, 14(04): 305-.